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MeSH Review

Fetal Weight

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Disease relevance of Fetal Weight


High impact information on Fetal Weight

  • We found that rat placental 11 beta-OHSD activity correlated positively with term fetal weight and negatively with placental weight [6].
  • Deletion of Pog is also accompanied by reduced embryonic body weight and, on some genetic backgrounds, embryonic lethality [7].
  • Acetylsalicylic acid, 55-90 mg/kg of estimated fetal weight, then was administered into the fetal stomach [8].
  • Fetal body weight was depressed by 21% overall, the magnitude of reduction related to length of time in utero after STZ injection [9].
  • Fetal body weight and body length were significantly (p less than 0.05-0.001) reduced in the hyperglycaemic rats compared to normal rats, as was the thymidine incorporation into rib cartilage (p less than 0.02) [10].

Chemical compound and disease context of Fetal Weight

  • A significant correlation between both maternal plasma triglyceride and nonesterified fatty acid levels with placental or fetal triglyceride content was found, although fetal weight did not change significantly [11].
  • In fetuses that were below about 40% of normal size, and in which placental blood was below about 30% of control, fetal weight was less sensitive to falls in blood glucose, which in turn was more sensitive than normal to a fall in maternal placental blood flow [12].
  • Isometric force increased progressively with age, reaching 4.1 +/- 0.4 mN for K+ and 5.8 +/- 0.5 mN for ACh (10(-4) M) at 600 g fetal weight (90 days) [13].
  • Higher enzymic activity was recorded with increased fetal body weight, but the reverse was true for taurine level [14].
  • The highest dose of fenofibrate decreased fetal weight [15].

Biological context of Fetal Weight


Anatomical context of Fetal Weight


Gene context of Fetal Weight

  • Circulating IGF-I is positively correlated with fetal weight (r = 0.66, P = 0.03), circulating IGFBP-3 (r = 0.54, P = 0.01) and IGFBP-4 (r = 0.52, P = 0.01) [26].
  • By contrast, cord serum IGFBP-1 from CS group without labor may preeminently reflect fetal weight [27].
  • In animal experiments, placental weight but not fetal weight was suppressed when EGF antiserum was administrated to maternal mice, however, fetal lung maturity in terms of lamella body produced in type II alveolar cells was suppressed in antiserum given group [28].
  • Pair-feeding db/+ mothers to the intake of WT mothers normalized fetal weight despite less than normal maternal insulin sensitivity [29].
  • Fetal weight and instantaneous growth rate (IGR) were positively correlated to maternal NEFA and PL and negatively correlated to maternal IGF-I and IGF-II [30].

Analytical, diagnostic and therapeutic context of Fetal Weight


  1. Transplacental uptake of WR 2721 by the rat embryo. Davis, M.E., Conger, A.D., Sodicoff, M. Int. J. Radiat. Oncol. Biol. Phys. (1987) [Pubmed]
  2. Effects of different levels of pyridoxine fed during pregnancy superimposed upon growth in the rat. Kirksey, A., Pang, R.L., Lin, W.J. J. Nutr. (1975) [Pubmed]
  3. Fetal plasma leptin concentrations: relationship with different intrauterine growth patterns from 19 weeks to term. Cetin, I., Morpurgo, P.S., Radaelli, T., Taricco, E., Cortelazzi, D., Bellotti, M., Pardi, G., Beck-Peccoz, P. Pediatr. Res. (2000) [Pubmed]
  4. Placental nutrient transfer capacity and fetal growth. Haggarty, P., Allstaff, S., Hoad, G., Ashton, J., Abramovich, D.R. Placenta (2002) [Pubmed]
  5. Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood. Langdown, M.L., Holness, M.J., Sugden, M.C. J. Endocrinol. (2001) [Pubmed]
  6. Glucocorticoid exposure in utero: new model for adult hypertension. Benediktsson, R., Lindsay, R.S., Noble, J., Seckl, J.R., Edwards, C.R. Lancet (1993) [Pubmed]
  7. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Agoulnik, A.I., Lu, B., Zhu, Q., Truong, C., Ty, M.T., Arango, N., Chada, K.K., Bishop, C.E. Hum. Mol. Genet. (2002) [Pubmed]
  8. Effects of acetylsalicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Heymann, M.A., Rudolph, A.M. Circ. Res. (1976) [Pubmed]
  9. Effects of fetal insulin deficiency on growth in fetal lambs. Philipps, A.F., Rosenkrantz, T.S., Clark, R.M., Knox, I., Chaffin, D.G., Raye, J.R. Diabetes (1991) [Pubmed]
  10. Skeletal growth of fetuses from streptozotocin diabetic rat mothers: in vivo and in vitro studies. Heinze, E., Vetter, U. Diabetologia (1987) [Pubmed]
  11. Maternal-fetal fat transport versus new fat synthesis in the pregnant diabetic rat. Shafrir, E., Khassis, S. Diabetologia (1982) [Pubmed]
  12. The effect of alterations in placental blood flow on the growth of and nutrient supply to the fetal guinea-pig. Jones, C.T., Parer, J.T. J. Physiol. (Lond.) (1983) [Pubmed]
  13. Early maturation of force production in pig tracheal smooth muscle during fetal development. Booth, R.J., Sparrow, M.P., Mitchell, H.W. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  14. Reevaluation of taurine levels and distribution of cysteic acid decarboxylase in developing human fetal brain regions. Datta, S.C. J. Neurochem. (1988) [Pubmed]
  15. Opposite metabolic response to fenofibrate treatment in pregnant and virgin rats. Soria, A., Bocos, C., Herrera, E. J. Lipid Res. (2002) [Pubmed]
  16. Prenatal ethanol exposure has differential effects on fetal growth and skeletal ossification. Simpson, M.E., Duggal, S., Keiver, K. Bone (2005) [Pubmed]
  17. Amniotic fluid amino acid concentrations are modified by maternal dietary glucose, gestational age, and fetal growth in rats. Gurekian, C.N., Koski, K.G. J. Nutr. (2005) [Pubmed]
  18. Fetoplacental growth and placental protein synthesis in rats after chronic maternal cocaine administration. Salhab, A.S., DeVane, C.L., Medrano, T., Buhi, W.C., Tebbett, I.R., Shiverick, K.T. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  19. Uterine environment and breed effects on erythropoiesis and liver protein secretion in late embryonic and early fetal swine. Pearson, P.L., Klemcke, H.G., Christenson, R.K., Vallet, J.L. Biol. Reprod. (1998) [Pubmed]
  20. Maternal dietary carbohydrate restriction and mild-to-moderate exercise during pregnancy modify aspects of fetal development in rats. Cobrin, M., Koski, K.G. J. Nutr. (1995) [Pubmed]
  21. Developmental hemodynamic changes in rat embryos at 11 to 15 days of gestation: normal data of blood pressure and the effect of caffeine compared to data from chick embryo. Nakazawa, M., Miyagawa, S., Ohno, T., Miura, S., Takao, A. Pediatr. Res. (1988) [Pubmed]
  22. The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Wong, J., Fineman, J.R., Heymann, M.A. Pediatr. Res. (1994) [Pubmed]
  23. The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight. Wang, H.S., Lim, J., English, J., Irvine, L., Chard, T. J. Endocrinol. (1991) [Pubmed]
  24. Influence of fetal fat on the ultrasound estimation of fetal weight in diabetic mothers. Bernstein, I.M., Catalano, P.M. Obstetrics and gynecology. (1992) [Pubmed]
  25. Cocaine and metabolites in amniotic fluid may prolong fetal drug exposure. Mahone, P.R., Scott, K., Sleggs, G., D'Antoni, T., Woods, J.R. Am. J. Obstet. Gynecol. (1994) [Pubmed]
  26. Circulating insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs) and tissue mRNA levels of IGFBP-2 and IGFBP-4 in the ovine fetus. Carr, J.M., Owens, J.A., Grant, P.A., Walton, P.E., Owens, P.C., Wallace, J.C. J. Endocrinol. (1995) [Pubmed]
  27. Effects of labor on serum levels of insulin and insulin-like growth factor-binding proteins at the time of delivery. Wang, H.S., Lee, J.D., Soong, Y.K. Acta obstetricia et gynecologica Scandinavica. (1995) [Pubmed]
  28. Role of growth factors on fetal growth and maturation. Takeda, Y., Iwashita, M. Ann. Acad. Med. Singap. (1993) [Pubmed]
  29. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Yamashita, H., Shao, J., Qiao, L., Pagliassotti, M., Friedman, J.E. Pediatr. Res. (2003) [Pubmed]
  30. Serum concentrations of insulin-like growth factors and placental lactogen during gestation in cattle. II. Maternal profiles. Hossner, K.L., Holland, M.D., Williams, S.E., Wallace, C.R., Niswender, G.D., Odde, K.G. Domest. Anim. Endocrinol. (1997) [Pubmed]
  31. Fetal rat islet insulin deficiency following maternal administration of streptozotocin. Hayek, A., Barela, T.D., Wogenrich, F.J., Guardian, C.M. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  32. Metabolic and cardiovascular changes during prolonged ritodrine infusion in fetal lambs. Bassett, J.M., Hanson, C., Weeding, C.M. Obstetrics and gynecology. (1989) [Pubmed]
  33. The metabolic clearance rate of epinephrine in the fetus of the diabetic ewe. Dickinson, J.E., Meyer, B.A., Chmielowiec, S., Palmer, S.M. Am. J. Obstet. Gynecol. (1991) [Pubmed]
  34. Constant rate exposure of pregnant hamsters to arsenate during early gestation. Ferm, V.H., Hanlon, D.P. Environmental research. (1985) [Pubmed]
  35. Axial skeletal malformations induced by acetazolamide in rabbits. Nakatsuka, T., Komatsu, T., Fujii, T. Teratology (1992) [Pubmed]
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