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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder.

A 67-year-old patient with large granular lymphocyte (LGL) leukemia is described. At fluorescence-activated cell sorting (FACS) analysis of the peripheral blood, the lymphocytes were positive for CD3, CD4, CD5, CD29, CD45RA, CD57, and TCR alpha/beta and negative for CD7, CD8, CD16, CD56, CD19, CD22, and TCR gamma/delta. Bone marrow histology and immunohistochemistry did not reveal any lymphocyte infiltration. Cytogenetic examination of peripheral blood cultures showed a clone with the karyotype 46,XY,t(3;5)(p26;q13). Molecular analysis revealed rearrangement of the gamma-T-cell-receptor chain. The region 3p25-3p26 which harbors the von Hippel-Lindau tumor suppressor gene and the RAF1 oncogene has been rearranged in a few cases of T-cell leukemia. The translocation in this case has not yet been described and may reflect an alternative mechanism in the pathogenesis of these disorders.[1]


  1. Translocation (3;5)(p26;q13) in a patient with chronic T-cell lymphoproliferative disorder. Schmidt, H.H., Pirc-Danoewinata, H., Panzer-Grümayer, E.R., Sill, H., Sedlmayr, P., Neumeister, P., Linkesch, W., Haas, O.A. Cancer Genet. Cytogenet. (1998) [Pubmed]
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