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Gene Review

ITGB1  -  integrin, beta 1 (fibronectin receptor,...

Homo sapiens

Synonyms: CD29, FNRB, Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, ...
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Disease relevance of ITGB1


High impact information on ITGB1


Chemical compound and disease context of ITGB1

  • In order to determine the cellular targets of AMI in human gastric cancer SC-M1 cells, we examined AMI-induced changes in the levels of adhesion molecules CD29 (beta 1 integrin) and CD54 (ICAM-1) and GSH [8].
  • A family with MEN 2A, consisting of 88 members and their spouses, was studied to test the reliability of the provocation of plasma calcitonin with pentagastrin and the possibility of DNA diagnosis of mutated gene carriers with DNA probes closely linked to the MEN2A gene including RBP3 and FNRB genes [9].

Biological context of ITGB1


Anatomical context of ITGB1


Associations of ITGB1 with chemical compounds


Physical interactions of ITGB1


Regulatory relationships of ITGB1

  • In contrast with the activating CD29 mAb 8A2, a combination of blocking CD49 mAbs or the nonactivating but blocking CD29 mAb AIIB2 failed to inhibit completely eosinophil migration over FN-preincubated or HUVEC-covered filters. mAb 8A2 stimulated binding to FN but not to HUVEC [26].
  • The above results strongly suggest that the VLA/CD29 family of antigens may play an important role in regulating CD4 T cell activation via the CD3-T cell receptor pathway [27].
  • However, a CD29 mAb which inhibits homotypic cell aggregation could not block this IL-8 production [28].
  • Pretreatment of neutrophils with either a CD29-stimulating monoclonal antibody or the addition of TNF-alpha (0.1-10 U/ml) to the coculture failed to induce transendothelial migration [29].
  • Monoclonal antibodies to beta1 integrins beta-subunit (CD29) also strongly induced tumor necrosis factor-alpha and interleukin-10 production, but not interleukin-12 [30].

Other interactions of ITGB1

  • Immunoelectron microscopy revealed fibers surrounded by cytoplasmic FDC extensions that were CD29-, CD49e-, and CD49f-positive [17].
  • Given that CD29 is currently regarded as critical for lymphocyte trafficking in general and for transvascular migration in particular, and CD54 is also involved in transvascular lymphocyte migration, we conclude that their consistent absence in IL may contribute to its intravascular and disseminated distribution pattern [19].
  • In all cases, the surfaces of IL aggregates reacted for CD44 but were consistently negative for CD29; also absent was CD54 [19].
  • No evidence for adhesion to vitronectin through CD29 and beta 5 integrins was obtained [15].
  • Neutralizing antibodies reactive with either alpha 4, VCAM-1, or CD29 were all equally capable of inhibiting the binding of activated leukocytes to mesothelial cells (in the presence of anti-CD18 antibody) [31].

Analytical, diagnostic and therapeutic context of ITGB1


  1. Proliferation and apoptosis-related gene expression in experimental acquired immunodeficiency syndrome-related simian lymphoma. Castaños-Vélez, E., Heiden, T., Ekman, M., Lawrence, J., Biberfeld, G., Biberfeld, P. Blood (1999) [Pubmed]
  2. The effect of antigen stimulation on alpha(4), beta(1) and beta(7) chain integrin expression and function in CD4+ cells. Tarkowski, M., Pacheco, K.A., Rosenwasser, L.J. Int. Arch. Allergy Immunol. (2000) [Pubmed]
  3. Increased expression of adhesion molecules (CD54, CD29 and CD44) on fibroblasts infected with cytomegalovirus. Ito, M., Watanabe, M., Ihara, T., Kamiya, H., Sakurai, M. Microbiol. Immunol. (1995) [Pubmed]
  4. Adhesion molecule expression on cerebrospinal fluid T lymphocytes: evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls. Svenningsson, A., Hansson, G.K., Andersen, O., Andersson, R., Patarroyo, M., Stemme, S. Ann. Neurol. (1993) [Pubmed]
  5. Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization. Scherberich, A., Moog, S., Haan-Archipoff, G., Azorsa, D.O., Lanza, F., Beretz, A. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  6. Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. Argraves, W.S., Dickerson, K., Burgess, W.H., Ruoslahti, E. Cell (1989) [Pubmed]
  7. Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes. Groux, H., Huet, S., Valentin, H., Pham, D., Bernard, A. Nature (1989) [Pubmed]
  8. Adamantyl maleimide induced changes in adhesion molecules and ROS are involved in apoptosis of human gastric cancer cells. Wang, J.J., Liu, T.Y., Yin, P.H., Wu, C.W., Chern, Y.T., Chi, C.W. Anticancer Res. (2000) [Pubmed]
  9. Prediction of affected MEN2A gene carriers by DNA linkage analysis for early total thyroidectomy: a progress in clinical screening program for children with hereditary cancer syndrome. Shimotake, T., Iwai, N., Yanagihara, J., Tokiwa, K., Tanaka, N., Yamamoto, M., Takai, S. J. Pediatr. Surg. (1992) [Pubmed]
  10. Gene expression profile changes in NB4 cells induced by arsenic trioxide. Wang, H.Y., Liu, S.X., Zhang, M. Acta Pharmacol. Sin. (2003) [Pubmed]
  11. Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. Podar, K., Tai, Y.T., Lin, B.K., Narsimhan, R.P., Sattler, M., Kijima, T., Salgia, R., Gupta, D., Chauhan, D., Anderson, K.C. J. Biol. Chem. (2002) [Pubmed]
  12. Adhesion molecules are upregulated on dendritic cells isolated from human blood. McCarthy, D.A., Macey, M.G., Bedford, P.A., Knight, S.C., Dumonde, D.C., Brown, K.A. Immunology (1997) [Pubmed]
  13. Influence of cytokine stimulation (granulocyte macrophage-colony stimulating factor, interleukin-3 and transforming growth factor-beta-1) on adhesion molecule expression in normal human bone marrow fibroblasts. Schmitz, B., Park, I.A., Kaufmann, R., Thiele, J., Fischer, R. Acta Haematol. (1995) [Pubmed]
  14. Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein. Nojima, Y., Rothstein, D.M., Sugita, K., Schlossman, S.F., Morimoto, C. J. Exp. Med. (1992) [Pubmed]
  15. Human mast cells derived from fetal liver cells cultured with stem cell factor express a functional CD51/CD61 (alpha v beta 3) integrin. Shimizu, Y., Irani, A.M., Brown, E.J., Ashman, L.K., Schwartz, L.B. Blood (1995) [Pubmed]
  16. Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells. Liesveld, J.L., Winslow, J.M., Frediani, K.E., Ryan, D.H., Abboud, C.N. Blood (1993) [Pubmed]
  17. Follicular dendritic cells adhere to fibronectin and laminin fibers via their respective receptors. Ogata, T., Yamakawa, M., Imai, Y., Takahashi, T. Blood (1996) [Pubmed]
  18. A new method for studying the selective adherence of blood lymphocytes to the microvasculature of human retina. Hill, T.A., Stanford, M.R., Graham, E.M., Dumonde, D.C., Brown, K.A. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  19. Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Ponzoni, M., Arrigoni, G., Gould, V.E., Del Curto, B., Maggioni, M., Scapinello, A., Paolino, S., Cassisa, A., Patriarca, C. Hum. Pathol. (2000) [Pubmed]
  20. Effects of integrin clustering on human lung mast cells and basophils. Lavens, S.E., Goldring, K., Thomas, L.H., Warner, J.A. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  21. Upregulated expression of VLA proteins and CD29 in peripheral blood lymphocytes of chronic alcoholics without ethanol-related diseases. Sacanella, E., Estruch, R., Gaya, A., Ferrer, K., Fernández-Sola, J., Alonso, J.R., Nicolás, J.M., Urbano-Márquez, A. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  22. Changes in numbers of epidermal cell adhesion molecules caused by oral cyclosporin in psoriasis. Edwards, B.D., Andrew, S.M., O'Driscoll, J.B., Chalmers, R.J., Ballardie, F.W., Freemont, A.J. J. Clin. Pathol. (1993) [Pubmed]
  23. The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation. Cho, J.Y., Fox, D.A., Horejsi, V., Sagawa, K., Skubitz, K.M., Katz, D.R., Chain, B. Blood (2001) [Pubmed]
  24. Characterization of the human platelet glycoprotein IIIa gene. Comparison with the fibronectin receptor beta-subunit gene. Lanza, F., Kieffer, N., Phillips, D.R., Fitzgerald, L.A. J. Biol. Chem. (1990) [Pubmed]
  25. Mechanisms of colon cancer binding to substratum and cells. Ebert, E.C. Dig. Dis. Sci. (1996) [Pubmed]
  26. Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration. Kuijpers, T.W., Mul, E.P., Blom, M., Kovach, N.L., Gaeta, F.C., Tollefson, V., Elices, M.J., Harlan, J.M. J. Exp. Med. (1993) [Pubmed]
  27. Cross-linking of VLA/CD29 molecule has a co-mitogenic effect with anti-CD3 on CD4 cell activation in serum-free culture system. Yamada, A., Nojima, Y., Sugita, K., Dang, N.H., Schlossman, S.F., Morimoto, C. Eur. J. Immunol. (1991) [Pubmed]
  28. A very late activating antigen-alpha4 (CD49d) monoclonal antibody, BU49 induces phosphorylation of a cAMP response element-binding protein (CREB), resulting in induction of homotypic cell aggregation and enhancement of interleukin-8 (IL-8) production. Ikewaki, N., Inoko, H. Microbiol. Immunol. (2002) [Pubmed]
  29. Cardiac surgery with extracorporeal circulation: neutrophil transendothelial migration is mediated by beta1 integrin (CD29) in the presence of TNF-alpha. Scholz, M., Nowak, P., Schuller, A., Margraf, S., Blaheta, R., Cinatl, J., Windolf, J., Moritz, A. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2004) [Pubmed]
  30. Cellular fibronectin is induced in ultraviolet-exposed human skin and induces IL-10 production by monocytes/macrophages. Yoshida, Y., Kang, K., Chen, G., Gilliam, A.C., Cooper, K.D. J. Invest. Dermatol. (1999) [Pubmed]
  31. Vascular cell adhesion molecule-1 expressed by peritoneal mesothelium partly mediates the binding of activated human T lymphocytes. Cannistra, S.A., Ottensmeier, C., Tidy, J., DeFranzo, B. Exp. Hematol. (1994) [Pubmed]
  32. Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Lokhorst, H.M., Lamme, T., de Smet, M., Klein, S., de Weger, R.A., van Oers, R., Bloem, A.C. Blood (1994) [Pubmed]
  33. Biological characteristics of human bone marrow mesenchymal stem cell cultured in vitro. Fa, X., Lixia, W., Hou, J., Zhang, R., Wang, H., Yang, C. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  34. Selective immunomodulation: utilization of CD29/VLA molecules. Morimoto, C., Sato, T., Tachibana, K. Artificial organs. (1996) [Pubmed]
  35. The beta subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies. Wu, J.S., Giuffra, L.A., Goodfellow, P.J., Myers, S., Carson, N.L., Anderson, L., Hoyle, L.S., Simpson, N.E., Kidd, K.K. Hum. Genet. (1989) [Pubmed]
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