Gene Review:
FGF2 - fibroblast growth factor 2 (basic)
Homo sapiens
Synonyms:
BFGF, Basic fibroblast growth factor, FGF-2, FGFB, Fibroblast growth factor 2, ...
Middel,
Basilico,
Ho,
Bouck,
Danese,
Moehler,
A. Sahni,
Gasbarrini,
Phillips,
Kim-Schulze,
Bellosta,
Krejci,
Zeisberg,
Neben,
van Kooten,
Pola,
Wilcox,
Schnaper,
de la Motte,
Nottet,
Willis,
Prats,
Zhang,
Becker,
Farrington-Rock,
C.W. Francis,
Kraemer,
Verhoef,
Boven,
Fiocchi,
Portegies,
Raschke,
Sahni,
Hillengass,
Benner,
Müller,
Strutz,
Chubinskaya,
Masri,
Im,
West,
Lowe,
Pacione,
P.J. Simpson-Haidaris,
G.G. Vaday,
Thompson,
Jansen,
Rutella,
Sans,
Egerer,
S.K. Sahni,
Salazar,
Volpert,
Loeser,
Graziani,
Renziehausen,
Mansukhani,
Shi,
Goldschmidt,
- Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44. Hibino, S., Shibuya, M., Hoffman, M.P., Engbring, J.A., Hossain, R., Mochizuki, M., Kudoh, S., Nomizu, M., Kleinman, H.K. Cancer Res. (2005)
- Heparin affin regulatory peptide/pleiotrophin mediates fibroblast growth factor 2 stimulatory effects on human prostate cancer cells. Hatziapostolou, M., Polytarchou, C., Katsoris, P., Courty, J., Papadimitriou, E. J. Biol. Chem. (2006)
- Bisindolylmaleimide I Suppresses Fibroblast Growth Factor-mediated Activation of Erk MAP Kinase in Chondrocytes by Preventing Shp2 Association with the Frs2 and Gab1 Adaptor Proteins. Krejci, P., Masri, B., Salazar, L., Farrington-Rock, C., Prats, H., Thompson, L.M., Wilcox, W.R. J. Biol. Chem. (2007)
- Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration. Guillonneau, X., Régnier-Ricard, F., Laplace, O., Jonet, L., Bryckaert, M., Courtois, Y., Mascarelli, F. Mol. Biol. Cell (1998)
- Human primitive neuroectodermal tumour cells behave as multipotent neural precursors in response to FGF2. Derrington, E.A., Dufay, N., Rudkin, B.B., Belin, M.F. Oncogene (1998)
- Critical periods of basic fibroblast growth factor and brain-derived neurotrophic factor in the development of the chicken cochleovestibular ganglion in vitro. Hossain, W.A., Rutledge, A., Morest, D.K. Exp. Neurol. (1997)
- Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease. Tooyama, I., Kremer, H.P., Hayden, M.R., Kimura, H., McGeer, E.G., McGeer, P.L. Brain Res. (1993)
- Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology. Anderson, A.J., Cummings, B.J., Cotman, C.W. Exp. Neurol. (1994)
- Overexpression of nerve growth factor and basic fibroblast growth factor in AIDS dementia complex. Boven, L.A., Middel, J., Portegies, P., Verhoef, J., Jansen, G.H., Nottet, H.S. J. Neuroimmunol. (1999)
- Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease. Albrecht, D., García, L., Cartier, L., Kettlun, A.M., Vergara, C., Collados, L., Valenzuela, M.A. AIDS Res. Hum. Retroviruses (2006)
- Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Aviezer, D., Hecht, D., Safran, M., Eisinger, M., David, G., Yayon, A. Cell (1994)
- Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Van Meir, E.G., Polverini, P.J., Chazin, V.R., Su Huang, H.J., de Tribolet, N., Cavenee, W.K. Nat. Genet. (1994)
- N-CoR controls differentiation of neural stem cells into astrocytes. Hermanson, O., Jepsen, K., Rosenfeld, M.G. Nature (2002)
- Maspin is an angiogenesis inhibitor. Zhang, M., Volpert, O., Shi, Y.H., Bouck, N. Nat. Med. (2000)
- Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Gohongi, T., Fukumura, D., Boucher, Y., Yun, C.O., Soff, G.A., Compton, C., Todoroki, T., Jain, R.K. Nat. Med. (1999)
- Identification of FGF receptor-binding peptides for cancer gene therapy. Maruta, F., Parker, A.L., Fisher, K.D., Hallissey, M.T., Ismail, T., Rowlands, D.C., Chandler, L.A., Kerr, D.J., Seymour, L.W. Cancer Gene Ther. (2002)
- Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. Barillari, G., Sgadari, C., Palladino, C., Gendelman, R., Caputo, A., Morris, C.B., Nair, B.C., Markham, P., Nel, A., Stürzl, M., Ensoli, B. J. Immunol. (1999)
- Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line. Murphy, P.R., Sato, Y., Knee, R.S. Mol. Endocrinol. (1992)
- Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells. Solan, J.L., Deftos, L.J., Goding, J.W., Terkeltaub, R.A. J. Bone Miner. Res. (1996)
- High plasma basic fibroblast growth factor concentration is associated with response to thalidomide in progressive multiple myeloma. Neben, K., Moehler, T., Egerer, G., Kraemer, A., Hillengass, J., Benner, A., Ho, A.D., Goldschmidt, H. Clin. Cancer Res. (2001)
- Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts. Mansukhani, A., Bellosta, P., Sahni, M., Basilico, C. J. Cell Biol. (2000)
- Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin. Yang, Y., Stopka, T., Golestaneh, N., Wang, Y., Wu, K., Li, A., Chauhan, B.K., Gao, C.Y., Cveklová, K., Duncan, M.K., Pestell, R.G., Chepelinsky, A.B., Skoultchi, A.I., Cvekl, A. EMBO J. (2006)
- A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Chen, L., Li, C., Qiao, W., Xu, X., Deng, C. Hum. Mol. Genet. (2001)
- Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Anderson, J., Burns, H.D., Enriquez-Harris, P., Wilkie, A.O., Heath, J.K. Hum. Mol. Genet. (1998)
- Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Ibrahimi, O.A., Eliseenkova, A.V., Plotnikov, A.N., Yu, K., Ornitz, D.M., Mohammadi, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Induction of inner ear fate by FGF3. Vendrell, V., Carnicero, E., Giraldez, F., Alonso, M.T., Schimmang, T. Development (2000)
- Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the "cooperative end structures" model. Zhang, Z., Coomans, C., David, G. J. Biol. Chem. (2001)
- Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2. de Alvaro, C., Martinez, N., Rojas, J.M., Lorenzo, M. Mol. Biol. Cell (2005)
- Epidermal growth factor and fibroblast growth factor 2 cause proliferation of ependymal precursor cells in the adult rat spinal cord in vivo. Kojima, A., Tator, C.H. J. Neuropathol. Exp. Neurol. (2000)
- alpha6beta1 integrin expression in hepatocarcinoma cells: regulation and role in cell adhesion and migration. Nejjari, M., Hafdi, Z., Dumortier, J., Bringuier, A.F., Feldmann, G., Scoazec, J.Y. Int. J. Cancer (1999)
- Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Ignatova, T.N., Kukekov, V.G., Laywell, E.D., Suslov, O.N., Vrionis, F.D., Steindler, D.A. Glia (2002)
- Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2. Song, S.J., Cool, S.M., Nurcombe, V. J. Cell. Biochem. (2007)
- Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). Sahni, A., Simpson-Haidaris, P.J., Sahni, S.K., Vaday, G.G., Francis, C.W. J. Thromb. Haemost. (2008)
- Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. Goodger, S.J., Robinson, C.J., Murphy, K.J., Gasiunas, N., Harmer, N.J., Blundell, T.L., Pye, D.A., Gallagher, J.T. J. Biol. Chem. (2008)
- Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells. Faraone, D., Aguzzi, M.S., Ragone, G., Russo, K., Capogrossi, M.C., Facchiano, A. Blood (2006)
- BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression. Hayashi, H., Ishisaki, A., Suzuki, M., Imamura, T. J. Cell. Sci. (2001)
- Plasmin-mediated fibroblast growth factor-2 mobilisation supports smooth muscle cell proliferation in human saphenous vein. George, S.J., Johnson, J.L., Smith, M.A., Jackson, C.L. J. Vasc. Res. (2001)
- Fibroblast growth factor-2 interacts with free ribosomal protein S19. Soulet, F., Al Saati, T., Roga, S., Amalric, F., Bouche, G. Biochem. Biophys. Res. Commun. (2001)
- Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. Camozzi, M., Rusnati, M., Bugatti, A., Bottazzi, B., Mantovani, A., Bastone, A., Inforzato, A., Vincenti, S., Bracci, L., Mastroianni, D., Presta, M. J. Biol. Chem. (2006)
- Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells. Zhang, W., Chuang, Y.J., Swanson, R., Li, J., Seo, K., Leung, L., Lau, L.F., Olson, S.T. Blood (2004)
- Functional Rac-1 and Nck signaling networks are required for FGF-2-induced DNA synthesis in MCF-7 cells. Liu, J.F., Chevet, E., Kebache, S., Lemaitre, G., Barritault, D., Larose, L., Crépin, M. Oncogene (1999)
- Ca(2+)-dependent stimulation of retinoblastoma gene product phosphorylation and p34cdc2 kinase activation in serum-stimulated human fibroblasts. Takuwa, N., Zhou, W., Kumada, M., Takuwa, Y. J. Biol. Chem. (1993)
- Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes. Loeser, R.F., Chubinskaya, S., Pacione, C., Im, H.J. Arthritis Rheum. (2005)
- Basic fibroblast growth factor suppresses p53 activation in the neoplastic cells of a proportion of patients with chronic lymphocytic leukaemia. Romanov, V.V., James, C.H., Sherrington, P.D., Pettitt, A.R. Oncogene (2005)
- Human chondrosarcoma secretes vascular endothelial growth factor to induce tumor angiogenesis and stores basic fibroblast growth factor for regulation of its own growth. Furumatsu, T., Nishida, K., Kawai, A., Namba, M., Inoue, H., Ninomiya, Y. Int. J. Cancer (2002)
- TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Strutz, F., Zeisberg, M., Renziehausen, A., Raschke, B., Becker, V., van Kooten, C., Müller, G. Kidney Int. (2001)
- Androgen receptor protein is down-regulated by basic fibroblast growth factor in prostate cancer cells. Cronauer, M.V., Nessler-Menardi, C., Klocker, H., Maly, K., Hobisch, A., Bartsch, G., Culig, Z. Br. J. Cancer (2000)
- During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Melder, R.J., Koenig, G.C., Witwer, B.P., Safabakhsh, N., Munn, L.L., Jain, R.K. Nat. Med. (1996)
- Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta. Fujitani, Y., Ninomiya, H., Okada, T., Urade, Y., Masaki, T. J. Clin. Invest. (1995)
- Fibroblast growth factor 2 and transforming growth factor beta 1 interactions in human liver myofibroblasts. Rosenbaum, J., Blazejewski, S., Préaux, A.M., Mallat, A., Dhumeaux, D., Mavier, P. Gastroenterology (1995)
- Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Danese, S., Sans, M., de la Motte, C., Graziani, C., West, G., Phillips, M.H., Pola, R., Rutella, S., Willis, J., Gasbarrini, A., Fiocchi, C. Gastroenterology (2006)
- Estrogen stimulates delayed mitogen-activated protein kinase activity in human endothelial cells via an autocrine loop that involves basic fibroblast growth factor. Kim-Schulze, S., Lowe, W.L., Schnaper, H.W. Circulation (1998)
- A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome. Tanimoto, Y., Yokozeki, M., Hiura, K., Matsumoto, K., Nakanishi, H., Matsumoto, T., Marie, P.J., Moriyama, K. J. Biol. Chem. (2004)
- Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2. De Cecco, L., Marchionni, L., Gariboldi, M., Reid, J.F., Lagonigro, M.S., Caramuta, S., Ferrario, C., Bussani, E., Mezzanzanica, D., Turatti, F., Delia, D., Daidone, M.G., Oggionni, M., Bertuletti, N., Ditto, A., Raspagliesi, F., Pilotti, S., Pierotti, M.A., Canevari, S., Schneider, C. Oncogene (2004)
- Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Huang, X., Yu, C., Jin, C., Yang, C., Xie, R., Cao, D., Wang, F., McKeehan, W.L. Mol. Carcinog. (2006)
- The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: The role of JNK signaling. Liao, S., Porter, D., Scott, A., Newman, G., Doetschman, T., Schultz, J.e.l. .J. J. Mol. Cell. Cardiol. (2007)