Disease relevance of Critical Care

• Cefmenoxime concentration/effect relationships were retrospectively explored for gram-negative bacteria isolated from 14 critical care patients treated for nosocomial pneumonia [1].
• Cefmenoxime is a promising agent in the treatment of susceptible pneumonias in critical care patients [2].
• Studies are required to determine whether American College of Critical Care Medicine guidelines for hemodynamic support of pediatric and neonatal septic shock will be implemented and associated with improved outcome [3].
• MODS was defined according to the original criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference 1992 [4].
• Practice guidelines for evaluating new fever in critically ill adult patients.Task Force of the Society of Critical Care Medicine and the Infectious Diseases Society of America [5].

Psychiatry related information on Critical Care

• Society of Critical Care Medicine Critical Care Self-Assessment Program III [6].

High impact information on Critical Care

• A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group [7].
• High-dose epinephrine did not produce longer hospital or critical care unit stays [8].
• SETTING: Critical care and telemetry units of two university-affiliated teaching institutions, Hartford Hospital and Henry Ford Hospital. PATIENTS: Fourteen digoxin-intoxicated patients (baseline total digoxin > 3.2 nmol/mL) with mean (+/- SD) serum creatinine of 380.1 +/- 212.2 mumol/L who received digoxin Fab antibody therapy [9].
• Suggestions, emendations, and other comments aimed at improving the reporting of pediatric resuscitation should be sent to Arno Zaritsky, MD, Eastern Virginia Medical School, Children's Hospital of the King's Daughter, Division of Critical Care Medicine, 601 Children's Lane, Norfolk, VA 23507 [10].
• Treatment with aztreonam or tobramycin in critical care patients with nosocomial gram-negative pneumonia [11].

Chemical compound and disease context of Critical Care

• Overall, aztreonam was superior to tobramycin for treatment of pneumonia due to susceptible gram-negative bacteria in these critical care patients [11].
• Then, the clinical interpretation of lactate measurements includes sections on the causes and treatments of hemodynamic deficits leading to lactic acidosis, the classification of lactate abnormalities, and the use of lactate measurements in critical care monitoring, including surgery [12].
• PATIENTS: 11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine [13].
• Carbon dioxide (CO2) as a contrast agent does not cause renal failure, but its accuracy in determining vena caval diameter (a critical factor in filter selection) and its safety in the critical care population are unknown [14].
• Clearance of ceftriaxone in critical care patients with acute renal failure [15].

Biological context of Critical Care

• SETTING: Work was conducted in the research laboratories of the Department of Anesthesiology, Critical Care Medicine at The Johns Hopkins Medical Institutions, Baltimore, MD [16].
• Unreported deviations of genotype distributions from Hardy-Weinberg equilibrium in articles published in Critical Care Medicine between 1999 and 2003 [17].
• Molecular biology for the critical care physician. Part II: where are we now [18]?
• Although they have fewer side-effects, they can cause significant physiological changes and drug interactions which have implications for the anaesthetist and the critical care physician, especially the potential to induce the serotonin syndrome [19].
• Pharmacokinetics of thiopental after single and multiple intravenous doses in critical care patients [20].

Anatomical context of Critical Care

• Clinical examination in the critical care unit is often unreliable and electrophysiologic studies, at times accompanied by magnetic resonance imaging of the spinal cord, measurement of the circulating creatine phosphokinase concentration, and muscle biopsy, are often necessary to establish the diagnosis [21].
• It is concluded that ketamine is a useful anesthetic agent for critical care research involving measurements of sympathetic nervous system activity [22].
• Cardiac output (CO) was measured using the transesophageal Doppler system Abbott ODM II (Abbott Critical Care Systems, Ireland), which was positioned in the esophagus after stabilization of anesthesia [23].

Associations of Critical Care with chemical compounds

• We examined the endogenous secretion of an anabolic protein, GH, and studied the effect exerted on its secretion by dopamine, a catecholamine that is frequently administered for cardiovascular purposes in critical care [24].
• We evaluated serial serum levels of LH, FSH, and testosterone (T) in 59 men and 42 postmenopausal women admitted to critical care units with a spectrum of disease severity [25].
• In surgical and critical care settings where clinical conditions are rapidly changing, the pharmacokinetic profile of esmolol allows the drug to provide rapid pharmacological control and minimises the potential for serious adverse effects [26].
• Frequent appearance of creatine kinase isoenzyme BB in sera of critical-care patients [27].
• The pulmonary physician and critical care. 6. Oxygen transport: the relation between oxygen delivery and consumption [28].

Gene context of Critical Care

• The presence of a G allele at the IL-6 -174 locus was associated with a higher incidence of organ failure (P=0.04) and an A allele at TNF-alpha -308 with prolonged critical care stay (P=0.03) [29].
• RESULTS: After elective AAA high levels of IL-10 were associated with both prolonged critical care (P<0.001) and hospital stay (P=0.001) [29].
• CONCLUSIONS: In a population of surviving children who were born at < or =32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices [30].
• RESULTS: The U.S. Air Force Critical Care Aeromedical Transport (CCAT) Teams were developed in 1994 in response to an unmet military need for long-range air transport of critically ill and injured patients [31].
• The results question the clinical and economic value of added control practices, such as closing of units, refusal of transfer or admission, added isolation, treatment of carriers, furlough of colonized staff, and other expensive measures that are specifically directed at prevention of MRSA infections in critical care areas [32].

Analytical, diagnostic and therapeutic context of Critical Care

• Understanding articles comparing outcomes among intensive care units to rate quality of care. Evidence Based Medicine in Critical Care Group [33].
• Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada [34].
• Management variables included data on length of critical care and hospital stay, ventilator and oxygen use, total parenteral nutritional use, number of transfusions, and the performance of various procedures [35].
• After cecal ligation and perforation, awake sheep were treated for 48 h with 10% pentastarch (n = 9), 10% pentafraction (Du Pont Critical Care; n = 8), or Ringer lactate (n = 8) titrated to maintain a constant left atrial pressure [36].
• Midazolam hydrochloride, a water-soluble benzodiazepine for intravenous injection, is frequently used to provide sedation to mechanically ventilated patients in the critical-care unit [37].

References