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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Critical Care

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Disease relevance of Critical Care


Psychiatry related information on Critical Care


High impact information on Critical Care


Chemical compound and disease context of Critical Care


Biological context of Critical Care


Anatomical context of Critical Care


Associations of Critical Care with chemical compounds

  • We examined the endogenous secretion of an anabolic protein, GH, and studied the effect exerted on its secretion by dopamine, a catecholamine that is frequently administered for cardiovascular purposes in critical care [24].
  • We evaluated serial serum levels of LH, FSH, and testosterone (T) in 59 men and 42 postmenopausal women admitted to critical care units with a spectrum of disease severity [25].
  • In surgical and critical care settings where clinical conditions are rapidly changing, the pharmacokinetic profile of esmolol allows the drug to provide rapid pharmacological control and minimises the potential for serious adverse effects [26].
  • Frequent appearance of creatine kinase isoenzyme BB in sera of critical-care patients [27].
  • The pulmonary physician and critical care. 6. Oxygen transport: the relation between oxygen delivery and consumption [28].

Gene context of Critical Care

  • The presence of a G allele at the IL-6 -174 locus was associated with a higher incidence of organ failure (P=0.04) and an A allele at TNF-alpha -308 with prolonged critical care stay (P=0.03) [29].
  • RESULTS: After elective AAA high levels of IL-10 were associated with both prolonged critical care (P<0.001) and hospital stay (P=0.001) [29].
  • CONCLUSIONS: In a population of surviving children who were born at < or =32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices [30].
  • RESULTS: The U.S. Air Force Critical Care Aeromedical Transport (CCAT) Teams were developed in 1994 in response to an unmet military need for long-range air transport of critically ill and injured patients [31].
  • The results question the clinical and economic value of added control practices, such as closing of units, refusal of transfer or admission, added isolation, treatment of carriers, furlough of colonized staff, and other expensive measures that are specifically directed at prevention of MRSA infections in critical care areas [32].

Analytical, diagnostic and therapeutic context of Critical Care


  1. Role for dual individualization with cefmenoxime. Schentag, J.J., Smith, I.L., Swanson, D.J., DeAngelis, C., Fracasso, J.E., Vari, A., Vance, J.W. Am. J. Med. (1984) [Pubmed]
  2. Cefmenoxime efficacy, safety, and pharmacokinetics in critical care patients with nosocomial pneumonia. Schentag, J.J., Reitberg, D.P., Cumbo, T.J. Am. J. Med. (1984) [Pubmed]
  3. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Carcillo, J.A., Fields, A.I. Crit. Care Med. (2002) [Pubmed]
  4. Multiple organ dysfunction in ulcerative colitis. Caprilli, R., Latella, G., Vernia, P., Frieri, G. Am. J. Gastroenterol. (2000) [Pubmed]
  5. Practice guidelines for evaluating new fever in critically ill adult patients.Task Force of the Society of Critical Care Medicine and the Infectious Diseases Society of America. O'Grady, N.P., Barie, P.S., Bartlett, J.G., Bleck, T., Garvey, G., Jacobi, J., Linden, P., Maki, D.G., Nam, M., Pasculle, W., Pasquale, M.D., Tribett, D.L., Masur, H. Clin. Infect. Dis. (1998) [Pubmed]
  6. Society of Critical Care Medicine Critical Care Self-Assessment Program III. Veremakis, C., Taylor, R.W. Crit. Care Med. (1983) [Pubmed]
  7. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Cook, D., Guyatt, G., Marshall, J., Leasa, D., Fuller, H., Hall, R., Peters, S., Rutledge, F., Griffith, L., McLellan, A., Wood, G., Kirby, A. N. Engl. J. Med. (1998) [Pubmed]
  8. A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest. Callaham, M., Madsen, C.D., Barton, C.W., Saunders, C.E., Pointer, J. JAMA (1992) [Pubmed]
  9. Influence of digoxin immune Fab therapy and renal dysfunction on the disposition of total and free digoxin. Ujhelyi, M.R., Robert, S., Cummings, D.M., Colucci, R.D., Green, P.J., Sailstad, J., Vlasses, P.H., Zarowitz, B.J. Ann. Intern. Med. (1993) [Pubmed]
  10. Recommended guidelines for uniform reporting of pediatric advanced life support: the pediatric Utstein Style. A statement for healthcare professionals from a task force of the American Academy of Pediatrics, the American Heart Association, and the European Resuscitation Council. Writing Group. Zaritsky, A., Nadkarni, V., Hazinski, M.F., Foltin, G., Quan, L., Wright, J., Fiser, D., Zideman, D., O'Malley, P., Chameides, L. Circulation (1995) [Pubmed]
  11. Treatment with aztreonam or tobramycin in critical care patients with nosocomial gram-negative pneumonia. Schentag, J.J., Vari, A.J., Winslade, N.E., Swanson, D.J., Smith, I.L., Simons, G.W., Vigano, A. Am. J. Med. (1985) [Pubmed]
  12. Blood lactate: biochemistry, laboratory methods, and clinical interpretation. Toffaletti, J.G. Critical reviews in clinical laboratory sciences. (1991) [Pubmed]
  13. The effects of low-dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock. Meier-Hellmann, A., Bredle, D.L., Specht, M., Spies, C., Hannemann, L., Reinhart, K. Intensive care medicine. (1997) [Pubmed]
  14. Safety and accuracy of bedside carbon dioxide cavography for insertion of inferior vena cava filters in the intensive care unit. Sing, R.F., Stackhouse, D.J., Jacobs, D.G., Heniford, B.T. J. Am. Coll. Surg. (2001) [Pubmed]
  15. Clearance of ceftriaxone in critical care patients with acute renal failure. Heinemeyer, G., Link, J., Weber, W., Meschede, V., Roots, I. Intensive care medicine. (1990) [Pubmed]
  16. Impaired cerebral autoregulation in the newborn lamb during recovery from severe, prolonged hypoxia, combined with carotid artery and jugular vein ligation. Short, B.L., Walker, L.K., Traystman, R.J. Crit. Care Med. (1994) [Pubmed]
  17. Unreported deviations of genotype distributions from Hardy-Weinberg equilibrium in articles published in Critical Care Medicine between 1999 and 2003. Németh, E., Vásárhelyi, B., Györffy, B., Kocsis, I. Crit. Care Med. (2004) [Pubmed]
  18. Molecular biology for the critical care physician. Part II: where are we now? Santis, G., Evans, T.W. Crit. Care Med. (1999) [Pubmed]
  19. Selective serotonin reuptake inhibitors. Pharmacology and clinical implications in anaesthesia and critical care medicine. Kam, P.C., Chang, G.W. Anaesthesia. (1997) [Pubmed]
  20. Pharmacokinetics of thiopental after single and multiple intravenous doses in critical care patients. Russo, H., Brès, J., Duboin, M.P., Roquefeuil, B. Eur. J. Clin. Pharmacol. (1995) [Pubmed]
  21. Sepsis and the systemic inflammatory response syndrome: neuromuscular manifestations. Bolton, C.F. Crit. Care Med. (1996) [Pubmed]
  22. Plasma, urine, and CSF catecholamine concentrations during and after ketamine anesthesia. Chernow, B., Lake, C.R., Cruess, D., Coyle, J., Hughes, P., Balestrieri, F., Casey, L., Rainey, T.G., Fletcher, J.R. Crit. Care Med. (1982) [Pubmed]
  23. Transesophageal Doppler ultrasonography evaluation of hemodynamic changes during videolaparoscopic cholecystectomy. Donati, A., Münch, C., Marini, B., Orsetti, G., Coltrinari, R., Pietropaoli, P. Minerva anestesiologica. (2002) [Pubmed]
  24. Growth hormone secretion in critical illness: effect of dopamine. Van den Berghe, G., de Zegher, F., Lauwers, P., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  25. Reproductive axis suppression in acute illness is related to disease severity. Spratt, D.I., Cox, P., Orav, J., Moloney, J., Bigos, T. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  26. Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics. Wiest, D. Clinical pharmacokinetics. (1995) [Pubmed]
  27. Frequent appearance of creatine kinase isoenzyme BB in sera of critical-care patients. Mercer, D.W. Clin. Chem. (1977) [Pubmed]
  28. The pulmonary physician and critical care. 6. Oxygen transport: the relation between oxygen delivery and consumption. Leach, R.M., Treacher, D.F. Thorax (1992) [Pubmed]
  29. Cytokines, their genetic polymorphisms, and outcome after abdominal aortic aneurysm repair. Bown, M.J., Horsburgh, T., Nicholson, M.L., Bell, P.R., Sayers, R.D. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2004) [Pubmed]
  30. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth? Harding, D.R., Dhamrait, S., Whitelaw, A., Humphries, S.E., Marlow, N., Montgomery, H.E. Pediatrics (2004) [Pubmed]
  31. The provision of sophisticated critical care beyond the hospital: lessons from physiology and military experiences that apply to civil disaster medical response. Grissom, T.E., Farmer, J.C. Crit. Care Med. (2005) [Pubmed]
  32. What's in a name? Is methicillin-resistant Staphylococcus aureus just another S aureus when treated with vancomycin? McManus, A.T., Mason, A.D., McManus, W.F., Pruitt, B.A. Archives of surgery (Chicago, Ill. : 1960) (1989) [Pubmed]
  33. Understanding articles comparing outcomes among intensive care units to rate quality of care. Evidence Based Medicine in Critical Care Group. Randolph, A.G., Guyatt, G.H., Carlet, J. Crit. Care Med. (1998) [Pubmed]
  34. Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada. Kost, G.J., Vu, H.T., Lee, J.H., Bourgeois, P., Kiechle, F.L., Martin, C., Miller, S.S., Okorodudu, A.O., Podczasy, J.J., Webster, R., Whitlow, K.J. Crit. Care Med. (1998) [Pubmed]
  35. Comparison of neonatal nurse practitioners, physician assistants, and residents in the neonatal intensive care unit. Carzoli, R.P., Martinez-Cruz, M., Cuevas, L.L., Murphy, S., Chiu, T. Archives of pediatrics & adolescent medicine. (1994) [Pubmed]
  36. Compared with crystalloid, colloid therapy slows progression of extrapulmonary tissue injury in septic sheep. Morisaki, H., Bloos, F., Keys, J., Martin, C., Neal, A., Sibbald, W.J. J. Appl. Physiol. (1994) [Pubmed]
  37. Effects of midazolam on electroencephalograms of seriously ill patients. Herkes, G.K., Wszolek, Z.K., Westmoreland, B.F., Klass, D.W. Mayo Clin. Proc. (1992) [Pubmed]
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