Disease relevance of ethynylbenzene

• In contrast, activity of pMMO in M. trichosporium OB3b, M. capsulatus Bath, Methylomicrobium album BG8, Methylobacter marinus A45 and Methylomonas strain MN was still measurable at phenylacetylene concentrations up to 1,000 microM [1].
• Phenylacetylene concentrations above 100 microM inhibited more than 90% of sMMO activity in Methylococcus capsulatus Bath and Methylosinus trichosporium OB3b [1].
• At phenylacetylene concentrations > 1 microM, whole-cell AMO activity in Nitrosomonas europaea was completely inhibited [1].
• In this paper, we investigated the inhibition of the phenol hydroxylase of Pseudomonas sp. CF600 by the alkyne phenylacetylene [2].

High impact information on ethynylbenzene

• The pincer-ligated species (PCP)Ir (PCP = kappa3-C6H3-2,6-(CH2PtBu2)2) is found to promote dimerization of phenylacetylene to give the enyne complex (PCP)Ir(trans-1,4-phenyl-but-3-ene-1-yne) [3].
• Platinum participation in the hydrogenation of phenylacetylene by Ru5(CO)15(C)[Pt(PBu(t)3)] [4].
• (6)Li, (13)C, and (19)F NMR spectroscopies show that deprotonation of quinazolinones and phenylacetylene in THF/pentane solutions with lithium hexamethyldisilazide affords a mixture of lithium quinazolinide/PhCCLi mixed dimer and mixed tetramer along with PhCCLi dimer [5].
• This contribution explores the relation between molecular second hyperpolarizabilities (gamma) and molecular architecture in phenylacetylene dendrimers using the semiempirical molecular orbital method, that is, INDO/S method [6].
• In contrast, the gamma(s)() value of D25 is found to be about 6 times as small as that of the para-substituted phenylacetylene oligomer (L25) composed of 24 units of phenylacetylenes [6].

Chemical compound and disease context of ethynylbenzene

• Phenylacetylene reversibly inhibits the phenol hydroxylase of Pseudomonas sp. CF600 at high concentrations but is oxidized at lower concentrations [2].

Biological context of ethynylbenzene

• Mechanism of acylation of lithium phenylacetylide with a Weinreb amide [7].
• The molecular structure of ethynylbenzene reported from microwave spectroscopy studies is shown to be inaccurate in the ipso region of the benzene ring [8].
• Length dependent folding kinetics of phenylacetylene oligomers: structural characterization of a kinetic trap [9].

Associations of ethynylbenzene with other chemical compounds

• Theoretical study on second hyperpolarizabilities of phenylacetylene dendrimer: toward an understanding of structure-property relation in NLO responses of fractal antenna dendrimers [6].

Gene context of ethynylbenzene

• However, the copolymers with the phenylacetylene bearing a tert-butyldimethylsiloxy group with intermediate bulkiness at the para position showed no ICD change with temperature [10].
• The enantioselective cycloaddition of CHT and phenylacetylene with BINOL phosphoramidite ligand 4 afforded the cycloadduct 3a (R = Ph) in 91% yield and 74% ee [11].
• The Sonogashira coupling reaction with TMSA and phenylacetylene, however, has now been extended to the bistriflate of p-tert-butylcalix[4]arene, previously known to be resistant to Stille, Neigishi, or Suzuki-Miyaura reactions [12].

Analytical, diagnostic and therapeutic context of ethynylbenzene

• The structures of 2-4 were established by IR with 13C-labeled phenylacetylene (Ph12C13CH), electrospray ionization mass spectrometry (ESI-MS), and NMR studies including 1H, 13C, distortionless enhancement by polarization transfer (DEPT), and correlation spectroscopy (COSY) experiments [13].

References