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Chemical Compound Review

diethylmethyl     pentane

Synonyms: pentan-3-yl, AC1L3I7W, 3-Pentyl, (CH3CH2)2CH, 23443-59-6, ...
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Disease relevance of pentane


Psychiatry related information on pentane

  • The results of the study indicate that anemia with increased globular volume of erythrocytes, elevated serum gamma-glutamyl-transferase activity, increased postprandial cholalemia, and increased elimination of pentane in the breath can be considered suitable markers for the early diagnosis of alcohol abuse [5].

High impact information on pentane


Chemical compound and disease context of pentane


Biological context of pentane

  • Mean (+/-SE) exhalation rates (pmol/kg b.wt./min) in 11 subjects were 2.4 +/- 0.6 for ethane and 1.5 +/- 1.3 for pentane [15].
  • The age-related increase in pentane production suggests that oxidative stress may play a role in the aging process in humans [16].
  • 4. The curve of the steady-state inactivation parameter (h infinity) for the Na current against membrane potential was shifted by the pentane in a hyperpolarizing direction (at h infinity = 0.5 this shift was approx. -15 mV in 275 microM-pentane) and the slope at all potentials was reduced [17].
  • 1. The anaesthetic effects of aqueous solutions of the n-alkanes pentane to nonane on the propagated action potential of squid axons have been investigated for a range of axon diameters [18].
  • Maximum ethane and pentane correlated with gestational age (r = -0.42, p = 0.03 and r = -0.52, p = 0.005, respectively) and birth weight (r = -0.38, p = 0.05 and r = -0.59, p = 0.001, respectively) [19].

Anatomical context of pentane


Associations of pentane with other chemical compounds


Gene context of pentane

  • Plasma antioxidant micronutrient status, breath pentane output, plasma lipid peroxides, malondialdehyde and viral load were measured at baseline and at 3 months [24].
  • Crystals have been obtained of seryl-tRNA synthetase from the extreme thermophile Thermus thermophilus, using mixed solutions of ammonium sulphate and methane pentane diol [29].
  • The activation energy for the decay of benzoylnitrene in pentane is -3.20 +/- 0.02 kcal/mol [30].
  • The eluate obtained from PBA column is then chromatographed on a reversed-phase C18 column with a mobile phase containing pentane- and heptanesulfonate as ion-pair reagents [31].
  • Ethane and pentane in breath are markers of oxidative stress, produced by ROS-mediated lipid peroxidation of n-3 and n-6 polyunsaturated fatty acids (PUFAs), but little is known about other n-alkanes in normal human breath [32].

Analytical, diagnostic and therapeutic context of pentane


  1. High breath pentane concentrations during acute myocardial infarction. Weitz, Z.W., Birnbaum, A.J., Sobotka, P.A., Zarling, E.J., Skosey, J.L. Lancet (1991) [Pubmed]
  2. Cystic fibrosis, breath pentane, and lipid peroxidation. Bilton, D., Maddison, J., Webb, A.K., Seabra, L., Jones, M., Braganza, J.M. Lancet (1991) [Pubmed]
  3. Breath pentane and plasma lipid peroxides in ischemic heart disease. Mendis, S., Sobotka, P.A., Leja, F.L., Euler, D.E. Free Radic. Biol. Med. (1995) [Pubmed]
  4. Breathing 100% oxygen after global brain ischemia in Mongolian Gerbils results in increased lipid peroxidation and increased mortality. Mickel, H.S., Vaishnav, Y.N., Kempski, O., von Lubitz, D., Weiss, J.F., Feuerstein, G. Stroke (1987) [Pubmed]
  5. Biological markers and therapeutic outcome in alcoholic disease: a twelve-year survey. Fantozzi, R., Caramelli, L., Ledda, F., Moroni, F., Masini, E., Blandina, P., Botti, P., Peruzzi, S., Zorn, A.M., Mannaioni, P.F. Klin. Wochenschr. (1987) [Pubmed]
  6. Pentane clearance from inspired air by the rat: dependence on the liver. Burk, R.J., Ludden, T.M., Lane, J.M. Gastroenterology (1983) [Pubmed]
  7. Incorporation of membrane proteins into large single bilayer vesicles. Application to rhodopsin. Darszon, A., Vandenberg, C.A., Ellisman, M.H., Montal, M. J. Cell Biol. (1979) [Pubmed]
  8. Interaction of ubisemiquinone with a paramagnetic component in heart tissue. Ruzicka, F.J., Beinert, H., Schepler, K.L., Dunham, W.R., Sands, R.H. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  9. Mitochondrial ubiquinone homologues, superoxide radical generation, and longevity in different mammalian species. Lass, A., Agarwal, S., Sohal, R.S. J. Biol. Chem. (1997) [Pubmed]
  10. Correlation of free oxygen radical-induced lipid peroxidation with outcome in very low birth weight infants. Pitkänen, O.M., Hallman, M., Andersson, S.M. J. Pediatr. (1990) [Pubmed]
  11. Assessment of lipid peroxidation in newborn infants and rabbits by measurements of expired ethane and pentane: influence of parenteral lipid infusion. Wispe, J.R., Bell, E.F., Roberts, R.J. Pediatr. Res. (1985) [Pubmed]
  12. Breath alkanes determination in ulcerative colitis and Crohn's disease. Pelli, M.A., Trovarelli, G., Capodicasa, E., De Medio, G.E., Bassotti, G. Dis. Colon Rectum (1999) [Pubmed]
  13. Lipid peroxidation: a mechanism involved in acute ethanol toxicity as demonstrated by in vivo pentane production in the rat. Litov, R.E., Irving, D.H., Downey, J.E., Tappel, A.L. Lipids (1978) [Pubmed]
  14. Lipid peroxidation and copper toxicity in rats. Dillard, C.J., Tappel, A.L. Drug and chemical toxicology. (1984) [Pubmed]
  15. A practical and reliable method for measuring ethane and pentane in expired air from humans. Knutson, M.D., Lim, A.K., Viteri, F.E. Free Radic. Biol. Med. (1999) [Pubmed]
  16. Pentane and isoprene in expired air from humans: gas-chromatographic analysis of single breath. Mendis, S., Sobotka, P.A., Euler, D.E. Clin. Chem. (1994) [Pubmed]
  17. Some effects of n-pentane on the sodium and potassium currents of the squid giant axon. Haydon, D.A., Kimura, J.E. J. Physiol. (Lond.) (1981) [Pubmed]
  18. Nerve impulse blockage in squid axons by n-alkanes: the effect of axon diameter. Haydon, D.A., Hendry, B.M. J. Physiol. (Lond.) (1982) [Pubmed]
  19. Immaturity-dependent free radical activity in premature infants. Varsila, E., Pitkänen, O., Hallman, M., Andersson, S. Pediatr. Res. (1994) [Pubmed]
  20. Pitfalls in the use of breath pentane measurements to assess lipid peroxidation. Springfield, J.R., Levitt, M.D. J. Lipid Res. (1994) [Pubmed]
  21. Phenylhydrazine-induced lipid peroxidation of red blood cells in vitro and in vivo: monitoring by the production of volatile hydrocarbons. Clemens, M.R., Remmer, H., Waller, H.D. Biochem. Pharmacol. (1984) [Pubmed]
  22. Fluidizing effect of endogenous ubiquinone in bovine heart mitochondrial membranes. Fato, R., Bertoli, E., Parenti Castelli, G., Lenaz, G. FEBS Lett. (1984) [Pubmed]
  23. Lipid peroxidation dependent aldrin epoxidation in liver microsomes, hepatocytes and granulation tissue cells. Lang, B., Maier, P. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  24. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects. Allard, J.P., Aghdassi, E., Chau, J., Tam, C., Kovacs, C.M., Salit, I.E., Walmsley, S.L. AIDS (1998) [Pubmed]
  25. Insight into binding of alkanes to transition metals from NMR spectroscopy of isomeric pentane and isotopically labeled alkane complexes. Lawes, D.J., Geftakis, S., Ball, G.E. J. Am. Chem. Soc. (2005) [Pubmed]
  26. Gene mapping and gene enrichment by the avidin-biotin interaction: use of cytochrome-c as a polyamine bridge. Sodja, A., Davidson, N. Nucleic Acids Res. (1978) [Pubmed]
  27. Increased lipid peroxidation after lipid infusion as measured by breath pentane output. Van Gossum, A., Shariff, R., Lemoyne, M., Kurian, R., Jeejeebhoy, K. Am. J. Clin. Nutr. (1988) [Pubmed]
  28. Oxygen-concentration dependence of microsomal chemiluminescence. Puntarulo, S., Turrens, J.F., Cederbaum, A.I. Free Radic. Biol. Med. (1989) [Pubmed]
  29. Crystals of seryl-tRNA synthetase from Thermus thermophilus. Preliminary crystallographic data. Garber, M.B., Yaremchuk, A.D., Tukalo, M.A., Egorova, S.P., Berthet-Colominas, C., Leberman, R. J. Mol. Biol. (1990) [Pubmed]
  30. A comparison of acetyl- and methoxycarbonylnitrenes by computational methods and a laser flash photolysis study of benzoylnitrene. Liu, J., Mandel, S., Hadad, C.M., Platz, M.S. J. Org. Chem. (2004) [Pubmed]
  31. Improved solid-phase extraction and liquid chromatography with electrochemical detection of urinary catecholamines and 5-S-L-cysteinyl-L-dopa. Huang, T.H., Wall, J., Kabra, P. J. Chromatogr. (1988) [Pubmed]
  32. Effect of age on the profile of alkanes in normal human breath. Phillips, M., Greenberg, J., Cataneo, R.N. Free Radic. Res. (2000) [Pubmed]
  33. Plasma vitamin E and selenium and breath pentane in home parenteral nutrition patients. Lemoyne, M., Van Gossum, A., Kurian, R., Jeejeebhoy, K.N. Am. J. Clin. Nutr. (1988) [Pubmed]
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