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Gene Review

Ppp1r1b  -  protein phosphatase 1, regulatory...

Mus musculus

Synonyms: AU040756, DARPP-32, Darpp32, Dopamine-and cAMP-regulated neuronal phosphoprotein, Protein phosphatase 1 regulatory subunit 1B
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Psychiatry related information on Ppp1r1b


High impact information on Ppp1r1b


Chemical compound and disease context of Ppp1r1b


Biological context of Ppp1r1b


Anatomical context of Ppp1r1b


Associations of Ppp1r1b with chemical compounds


Enzymatic interactions of Ppp1r1b

  • However, the absence of normal DA tone generated significant alterations in DA D1-receptor signalling as indicated by increased mutant striatal levels of phosphorylated DARPP-32 and by an altered motor response to amphetamine [15].
  • DARPP-32 is also phosphorylated by cyclin-dependent kinase 5 on Thr75, and the phosphorylated form of DARPP-32 at Thr75 inhibits protein kinase (PKA) activity [16].

Regulatory relationships of Ppp1r1b


Other interactions of Ppp1r1b


Analytical, diagnostic and therapeutic context of Ppp1r1b


  1. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. Beaulieu, J.M., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G. J. Biol. Chem. (2006) [Pubmed]
  2. Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1. Zachariou, V., Benoit-Marand, M., Allen, P.B., Ingrassia, P., Fienberg, A.A., Gonon, F., Greengard, P., Picciotto, M.R. Biol. Psychiatry (2002) [Pubmed]
  3. DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task. Heyser, C.J., Fienberg, A.A., Greengard, P., Gold, L.H. Brain Res. (2000) [Pubmed]
  4. Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Lindskog, M., Svenningsson, P., Pozzi, L., Kim, Y., Fienberg, A.A., Bibb, J.A., Fredholm, B.B., Nairn, A.C., Greengard, P., Fisone, G. Nature (2002) [Pubmed]
  5. Requirement for DARPP-32 in progesterone-facilitated sexual receptivity in female rats and mice. Mani, S.K., Fienberg, A.A., O'Callaghan, J.P., Snyder, G.L., Allen, P.B., Dash, P.K., Moore, A.N., Mitchell, A.J., Bibb, J., Greengard, P., O'Malley, B.W. Science (2000) [Pubmed]
  6. Phosphorylation of DARPP-32 at Threonine-34 is required for cocaine action. Zachariou, V., Sgambato-Faure, V., Sasaki, T., Svenningsson, P., Berton, O., Fienberg, A.A., Nairn, A.C., Greengard, P., Nestler, E.J. Neuropsychopharmacology (2006) [Pubmed]
  7. N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington's disease mice. van Dellen, A., Welch, J., Dixon, R.M., Cordery, P., York, D., Styles, P., Blakemore, C., Hannan, A.J. Neuroreport (2000) [Pubmed]
  8. Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32. Svenningsson, P., Fienberg, A.A., Allen, P.B., Moine, C.L., Lindskog, M., Fisone, G., Greengard, P., Fredholm, B.B. J. Neurochem. (2000) [Pubmed]
  9. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.C., Stipanovich, A., Caboche, J., Lombroso, P.J., Nairn, A.C., Greengard, P., Hervé, D., Girault, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Increased blood pressure and loss of anp-induced natriuresis in mice lacking DARPP-32 gene. Eklöf, A.C., Holtbäck, U., Svennilson, J., Fienberg, A., Greengard, P., Aperia, A. Clin. Exp. Hypertens. (2001) [Pubmed]
  11. DARPP-32 and inhibitor-1 are expressed in pancreatic beta-cells. Lilja, L., Meister, B., Berggren, P.O., Bark, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Maldve, R.E., Zhang, T.A., Ferrani-Kile, K., Schreiber, S.S., Lippmann, M.J., Snyder, G.L., Fienberg, A.A., Leslie, S.W., Gonzales, R.A., Morrisett, R.A. Nat. Neurosci. (2002) [Pubmed]
  13. Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Nishi, A., Watanabe, Y., Higashi, H., Tanaka, M., Nairn, A.C., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro. Bogush, A., Pedrini, S., Pelta-Heller, J., Chan, T., Yang, Q., Mao, Z., Sluzas, E., Gieringer, T., Ehrlich, M.E. J. Biol. Chem. (2007) [Pubmed]
  15. Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice. Borgkvist, A., Puelles, E., Carta, M., Acampora, D., Ang, S.L., Wurst, W., Goiny, M., Fisone, G., Simeone, A., Usiello, A. Mol. Cell. Neurosci. (2006) [Pubmed]
  16. Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling. Matsuyama, S., Fukui, R., Higashi, H., Nishi, A. Eur. J. Neurosci. (2003) [Pubmed]
  17. Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. Hiroi, N., Fienberg, A.A., Haile, C.N., Alburges, M., Hanson, G.R., Greengard, P., Nestler, E.J. Eur. J. Neurosci. (1999) [Pubmed]
  18. Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo. Snyder, G.L., Allen, P.B., Fienberg, A.A., Valle, C.G., Huganir, R.L., Nairn, A.C., Greengard, P. J. Neurosci. (2000) [Pubmed]
  19. Cyclin-dependent kinase 5 promotes insulin exocytosis. Lilja, L., Yang, S.N., Webb, D.L., Juntti-Berggren, L., Berggren, P.O., Bark, C. J. Biol. Chem. (2001) [Pubmed]
  20. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. Liu, F., Virshup, D.M., Nairn, A.C., Greengard, P. J. Biol. Chem. (2002) [Pubmed]
  21. The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalon. Waclaw, R.R., Wang, B., Campbell, K. Development (2004) [Pubmed]
  22. Bidirectional regulation of DARPP-32 phosphorylation by dopamine. Nishi, A., Snyder, G.L., Greengard, P. J. Neurosci. (1997) [Pubmed]
  23. Regulation of AMPA receptor dephosphorylation by glutamate receptor agonists. Snyder, G.L., Galdi, S., Fienberg, A.A., Allen, P., Nairn, A.C., Greengard, P. Neuropharmacology (2003) [Pubmed]
  24. DARPP-32 phosphorylation opposes the behavioral effects of nicotine. Zhu, H., Lee, M., Guan, F., Agatsuma, S., Scott, D., Fabrizio, K., Fienberg, A.A., Hiroi, N. Biol. Psychiatry (2005) [Pubmed]
  25. Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain. Perez, R.G., Lewis, R.M. J. Comp. Neurol. (1992) [Pubmed]
  26. Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32. Zhang, Y., Svenningsson, P., Picetti, R., Schlussman, S.D., Nairn, A.C., Ho, A., Greengard, P., Kreek, M.J. J. Neurosci. (2006) [Pubmed]
  27. Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Kurihara, T., Lewis, R.M., Eisler, J., Greengard, P. J. Neurosci. (1988) [Pubmed]
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