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Chemical Compound Review

Calsed     (7S,9R)-9-amino-7- [(2S,4S,5R)-4,5...

Synonyms: Calsed (TN), CHEMBL481958, SureCN491010, SM-5887, LS-94007, ...
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Disease relevance of (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxytetrahydropyran-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione


High impact information on (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxytetrahydropyran-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

  • The effects of SM5887 in combination with 5-fluorouracil, cytarabine or vincristine may be variable, depending on cell lines [3].
  • Effects of 13-hydroxy SM5887 in combination with other anticancer agents on human tumor cell lines [3].
  • The acute toxic signs observed after SM-5887 administration were body weight decrease, ataxia, hair loss, and myelosuppression [4].
  • In addition, the 10-day-interval repeated iv treatments with SM-5887 at the MTD (25 mg/kg) resulted in remarkably potent antitumor effects (including complete regression) against human gastric cancer, 4-1ST, implanted in nude mice without enhancement of toxic effects [5].
  • The gene transfer of AdIkappaBalpha decreased IC50 from 12.0 to 2.2 nM on paclitaxel and increased IC50 from 0.27 to 16.0 microM on SM5887 compared with the transfer of control gene, AdLacZ [6].

Analytical, diagnostic and therapeutic context of (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxytetrahydropyran-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione


  1. Chronic effects of a novel synthetic anthracycline derivative (SM-5887) on normal heart and doxorubicin-induced cardiomyopathy in beagle dogs. Noda, T., Watanabe, T., Kohda, A., Hosokawa, S., Suzuki, T. Investigational new drugs. (1998) [Pubmed]
  2. Cardiotoxicity of a new anthracycline derivative (SM-5887) following intravenous administration to rabbits: comparative study with doxorubicin. Suzuki, T., Minamide, S., Iwasaki, T., Yamamoto, H., Kanda, H. Investigational new drugs. (1997) [Pubmed]
  3. Effects of 13-hydroxy SM5887 in combination with other anticancer agents on human tumor cell lines. Takagi, T., Yazawa, Y., Suzuki, K., Yamauchi, Y., Kano, Y. Investigational new drugs. (1996) [Pubmed]
  4. Toxicological aspects of a novel 9-aminoanthracycline, SM-5887. Morisada, S., Yanagi, Y., Kashiwazaki, Y., Fukui, M. Jpn. J. Cancer Res. (1989) [Pubmed]
  5. Antitumor activities of a novel 9-aminoanthracycline (SM-5887) against mouse experimental tumors and human tumor xenografts. Morisada, S., Yanagi, Y., Noguchi, T., Kashiwazaki, Y., Fukui, M. Jpn. J. Cancer Res. (1989) [Pubmed]
  6. Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. Osaki, S., Nakanishi, Y., Takayama, K., Pei, X.H., Ueno, H., Hara, N. J. Exp. Clin. Cancer Res. (2003) [Pubmed]
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