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Chemical Compound Review:

AG-F-41328 (2S)-2-amino-3-benzothiazol- 2-ylsulfanyl...

Synonyms: CHEMBL2074983, SureCN8963327, AC1L3OQE, AC1Q5QNI, CTK4I2213, ...

MacFarlane, M. et al., Hwang, I.Y. et al., Stevens, J.L. et al., Elfarra, A.A. et al., Stevens, J.L., et al.

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High impact information on L-Cysteine, S-2-benzothiazolyl-

S-(2-Benzothiazolyl)-L-cysteine (BTC) is a poor substrate for purified glutamine transaminase K from mitochondria and cytosol, but BTC is as active as DCVC in crude mitochondrial matrix suggesting that other enzymes may be present [1].
Both alpha-keto-gamma-methiolbutyrate (KMB) and alpha-ketobutyrate enhanced the metabolism of S-(2-benzothiazolyl)-L-cysteine (BTC) to 2-mercaptobenzothiazole by rat renal cytosol or mitochondria [2].
The apparent Vmax value for the mitochondrial beta-lyase-dependent metabolism of S-(6-purinyl)-L-cysteine to yield 6-mercaptopurine was 4-fold greater than the rate measured with cytosol, whereas the rates of metabolism of S-(2-benzothiazolyl)-L-cysteine by the cytosolic and mitochondrial beta-lyase were similar [3].
The highly purified enzyme exhibited a monomeric molecular weight of 50,000 Da and was active in the alpha-beta elimination of cysteine conjugates including S-(1,2-dichlorovinyl)-L-cysteine (DCVC), S-(1,1,2,2-tetrafluoroethyl)-L-cysteine (TFEC), and S-(2-benzothiazolyl)-L-cysteine, particularly toward DCVC and TFEC [4].

Anatomical context of L-Cysteine, S-2-benzothiazolyl-

Kidney cortex cysteine conjugate beta-lyase enzymes were characterized using S-(2-benzothiazolyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine as substrates [5].

Gene context of L-Cysteine, S-2-benzothiazolyl-

In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities [6].

References

The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates. Stevens, J.L., Ayoubi, N., Robbins, J.D. J. Biol. Chem. (1988) [Pubmed]
Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine. Elfarra, A.A., Lash, L.H., Anders, M.W. Mol. Pharmacol. (1987) [Pubmed]
Cysteine S-conjugates may act as kidney-selective prodrugs: formation of 6-mercaptopurine by the renal metabolism of S-(6-purinyl)-L-cysteine. Hwang, I.Y., Elfarra, A.A. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity. MacFarlane, M., Foster, J.R., Gibson, G.G., King, L.J., Lock, E.A. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
Cysteine conjugate beta-lyase activities in rat kidney cortex: subcellular localization and relationship to the hepatic enzyme. Stevens, J.L. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities. Elfarra, A.A., Hwang, I.Y. Drug Metab. Dispos. (1990) [Pubmed]

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