Disease relevance of Zenite special

• Metabolism of 2-mercaptobenzothiazole by Rhodococcus rhodochrous [1].
• In a complementary autoradiographic study on the uptake of the potent tyrosinase inhibitor mercaptobenzothiazole (MBT) in B 16 melanoma transplanted to mice, it was found that strong tyrosinase inhibition seems to decrease incorporation into melanin in vitro [2].
• Hand involvement in allergic contact dermatitis from mercaptobenzothiazole in shoes [3].
• Dermatitis from mercaptobenzothiazole in a Foley catheter [4].
• Toxicity of 2-mercaptobenzothiazole towards bacterial growth and respiration [5].

High impact information on Zenite special

• Reaction of 2 with an organoaluminum thiolate generated from 2-mercaptobenzothiazole and trimethylaluminum followed by acetylation produced 3-O-acetyl-4-[(2-benzothiazolyl)thio]-5,7,3',4'-tetra-O-benzylepicatechin (12) [6].
• An impurity, discovered in a sample of digoxin injectable solution commercially packaged in a syringe for single-dose delivery, was found to originate from the rubber closure of the syringe and was identified as 2-mercaptobenzothiazole, a common accelerator for rubber vulcanization [7].
• Bikini dermatitis due to mercaptobenzothiazole [8].
• 2-Mercaptobenzothiazole and zinc dialkyldithiocarbamates are commonly used sulfur-containing rubber vulcanization accelerators known to cause allergic contact dermatitis [9].
• Synthesis, structural characterization and in vitro cytotoxicity of organotin(IV) derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2-mercaptobenzothiazole and 2-mercaptonicotinic acid [10].

Chemical compound and disease context of Zenite special

• Isolation, via activity-directed fractionation, of mercaptobenzothiazole and dibenzothiazyl disulfide as 2 allergens responsible for tennis shoe dermatitis [11].
• Dermatitis from shoes and an amputation prosthesis due to mercaptobenzthiazole and paratertiary butyl formaldehyde resin [12].
• Black patients readily acquire allergic contact dermatitis from such contactants as paraphenylenediamine, nickel, chromates, and mercaptobenzothiazole [13].
• Allergic reaction to neoprene is generally ascribed to the accelerants used to manufacture the man-made rubber, specifically thiourea compounds and mercaptobenzothiazole (MBT) [14].
• The objective of this article is to describe allergic contact dermatitis from sodium isopropyl xanthate, potassium amyl xanthate, and carbamates in a geotechnician, to discuss possible cross-reactions, and to report the widespread use of carbamates and mercaptobenzothiazole in mining processes [15].

Biological context of Zenite special

• A 30-min contact with the strong sensitizers DNBS and oxazolone, or the moderate mercaptobenzothiazole, resulted in upregulation of MHC class II molecules expression, analyzed after 18-h incubation [16].
• In vitro induction of polyploidy and chromatid exchanges by culture medium extracts of natural rubbers compounded with 2-mercaptobenzothiazole as a positive control candidate for genotoxicity tests [17].

Associations of Zenite special with other chemical compounds

• The aim of this study was to determine the sensitization potential of morpholine (M), 4,4'-dithiodimorpholine (DTDM), morpholinyl-mercaptobenzothiazole (MMBT) and 2-mercaptobenzothiazole (MBT) in guinea pigs [18].
• In buffer solution at pH 6.5, 2-mercaptobenzothiazole and the sulfenamide derivatives morpholinyl mercaptobenzothiazole and N-cyclohexyl-2-benzothiazyl sulfenamide were converted into dibenzothiazyl disulfide [19].
• An analytical quantitative high-pressure liquid chromatography (HPLC) method was developed for simultaneous determination of all mercaptobenzothiazole derivatives in the mercapto mix patch testing standard [19].
• In two cases, positive patch test reactions to paper size (rosin) and a slimicide, mercaptobenzothiazole (MBT), were noted [20].
• It was found that allergy to mercaptobenzthiazole (MBT)- and thiuram-containing condoms was relatively common and that latex/petroleum tube medical adhesives most commonly caused adhesive allergy [21].

Gene context of Zenite special

• PTBP resin and chromium proved to be the 2 principal allergens, but when lesions were localized to the soles, rubber additives, chiefly mercaptobenzothiazole, were the predominant ones [22].

Analytical, diagnostic and therapeutic context of Zenite special

• The compound was identified by UV spectrophotometry (including a pH-dependent shift in its absorbance maximum), by mass spectrometry, and by comparison with standard 2-mercaptobenzothiazole using silica gel and reverse-phase high-performance liquid chromatography (HPLC) [7].
• Contamination of injectable solutions with 2-mercaptobenzothiazole leached from rubber closures [7].
• In this study, optimization of the extraction technique monitored by quantitative HPLC analysis of the extracted haptens is described for mercaptobenzothiazole derivatives [23].
• False positive reaction to mercaptobenzthiazole from rubber in eyedrop bottle [24].
• The patient reacted to SP but not to MBT and MBTS, though SP, MBT and MBTS were determined in the causative shoes by gas chromatography (GC), GC-mass spectrometry (GC-MS) and HPLC [25].

References