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Chemical Compound Review

Indanidine HCl     N-(4,5-dihydro-1H-imidazol-2- yl)-2-methyl...

Synonyms: Sgd-10175, SureCN10952387, Sgd-101-75, AC1L3TNP, AR-1J8712, ...
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High impact information on Indanidinum

  • For an 80 mm Hg increase in blood pressure, full alpha-1 adrenoceptor agonists enhanced total peripheral, renal and mesenteric vascular resistances significantly more than alpha-2 adrenoceptor stimulants or indanidine [1].
  • All investigated compounds in low doses increased cardiac output, which returned to base-line values after high doses of alpha-1 but plateaued after high doses of alpha-2 adrenoceptor agonists or indanidine. alpha-1 adrenoceptor agonists decreased whereas alpha-2 stimulants and indanidine successively increased and then decreased renal blood flow [1].
  • Alkylation experiments showed that the contractile effects of Sgd 101/75 were more sensitive to POB than the effects of NE [2].
  • After both intravenous administration to conscious spontaneously hypertensive rats and intravenous injection or infusion via the vertebral artery in chloralose-anaesthetized cats, Sgd 101/75 (1-10 mg kg-1) elicited pressor responses [3].
  • In the pithed rat and pithed cat the vasopressor responses to i.v. Sgd 101/75 were effectively antagonized by prazosin (0.1-1.0 mg kg-1, i.v.) but much less by yohimbine (1 mg kg-1, i.v.). Sgd 101/75 proved a less potent and less selective displacing agent of [3H]-clonidine- and [3H]-prazosin-binding in rat brain membranes than clonidine [3].
 

Biological context of Indanidinum

  • Intracisternal application of Sgd 101/75 (1 mg kg-1) to chloralose-anaesthetized cats did not affect blood pressure [3].
  • In this respect, Sgd 101/75 is different from other alpha 1-adrenoceptor agonists, which are known to elicit a vasoconstriction which is virtually insensitive to vasodilatory measures and calcium entry blockade [4].
  • Sgd 101/75 is distinguished from other selective alpha 1-adrenoceptor agonists by the inhibition of its pressor responses by calcium entry blockade and vasodilatation in pithed rats and cats [4].
 

Anatomical context of Indanidinum

 

Associations of Indanidinum with other chemical compounds

 

Gene context of Indanidinum

  • Responsiveness to NPY and NPY13-36 but not to BAY or indanidine was markedly reduced 120 min following conditioning regardless of prior ring exposure to the same peptide; only prior exposure reduced responsiveness to [Leu31,Pro34]NPY [8].

References

  1. Systemic and regional hemodynamic characterization of alpha-1 and alpha-2 adrenoceptor agonists in pithed rats. Richer, C., Lefevre-Borg, F., Lechaire, J., Gomeni, C., Gomeni, R., Giudicelli, J.F., Cavero, I. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  2. Analysis of putative alpha-1s adrenoceptor agonism by Sgd 101/75 in the rat anococcygeus muscle. James, M.K., Leighton, H.J. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  3. Sgd 101/75: cardiovascular effects in various animal preparations; interactions with vascular postjunctional alpha 1- and alpha 2-adrenoceptors. Mathy, M.J., Thoolen, M.J., Timmermans, P.B., van Zwieten, P.A. Br. J. Pharmacol. (1984) [Pubmed]
  4. Sgd 101/75 is distinguished from other selective alpha 1-adrenoceptor agonists by the inhibition of its pressor responses by calcium entry blockade and vasodilatation in pithed rats and cats. Timmermans, P.B., Thoolen, M.J., Mathy, M.J., Wilffert, B., De Jonge, A., Van Zwieten, P.A. Eur. J. Pharmacol. (1983) [Pubmed]
  5. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity. Van der Graaf, P.H., Shankley, N.P., Black, J.W. Naunyn Schmiedebergs Arch. Pharmacol. (1996) [Pubmed]
  6. Changes in endothelium-dependent vascular responses associated with spontaneous hypertension and age in rats. Ibarra, M., Meneses, A., Ransanz, V., Castillo, C., Hong, E. Arch. Med. Res. (1995) [Pubmed]
  7. Effects of the irreversible alpha-adrenoceptor antagonists phenoxybenzamine and benextramine on the effectiveness of nifedipine in inhibiting alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in pithed rats. Timmermans, P.B., Thoolen, M.J., Mathy, M.J., Wilffert, B., de Jonge, A., van Zwieten, P.A. Naunyn Schmiedebergs Arch. Pharmacol. (1985) [Pubmed]
  8. Characterization of vascular postsynaptic NPY receptor function and regulation and differential sensitivity of Y1 and Y2 receptor function to changes in extracellular calcium availability and prior in vitro peptide exposure. Tessel, R.E., Miller, D.W., Misse, G.A., Dong, X., Doughty, M.B. Neuropeptides (1993) [Pubmed]
 
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