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Chemical Compound Review

Dibenylene     N-benzyl-N-(2-chloroethyl)-1- phenoxy...

Synonyms: Bensylyt, Benzylyt, Bensylyte, Dibenylin, Dibenyline, ...
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Disease relevance of phenoxybenzamine


Psychiatry related information on phenoxybenzamine


High impact information on phenoxybenzamine


Chemical compound and disease context of phenoxybenzamine


Biological context of phenoxybenzamine


Anatomical context of phenoxybenzamine


Associations of phenoxybenzamine with other chemical compounds


Gene context of phenoxybenzamine

  • Phenoxybenzamine (PbA) inhibited with about equal apparent potency all three hOCTs, whereas the PbA derivative SKF550 ((9-fluorenyl)-N-methyl-beta-chloroethylamine) preferentially inhibited hOCT3 and hOCT2 [33].
  • Injected intrathecally to mice, phenoxybenzamine blocked neurokinin-induced, but not bombesin- or somatostatin-induced, reciprocal hind limb scratching [34].
  • LH and FSH responses to GnRH pulses were preserved suggesting that PBZ blocked the post-OVX increase in hypothalamic GnRH secretion [35].
  • The suppressive effect of PBZ appeared to be specific to the hypothalamic-pituitary-ovarian axis as plasma PRL, TSH, and corticosterone were not decreased compared to controls [35].
  • A PBZ regimen of 15 mg/kg ip at OVX followed by 10 mg/kg at 24 h and 5 mg/kg at 48 h prevented the increase in alpha, LH-beta, and FSH-beta mRNAs and LH and FSH secretion for 72 h post-OVX [35].

Analytical, diagnostic and therapeutic context of phenoxybenzamine


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