Disease relevance of nephritogenoside

• Nephritogenoside is a glycopeptide with the ability to induce chronic progressive glomerulonephritis (end stage kidney) in homologous animals, by a single footpad injection [1].
• These results indicate that crude nephritogenoside preparation contains Heymann's antigen as an inducing factor of membranous glomerulonephritis in homologous animals [2].
• In a preclinical study, especially of 1 alpha-hydroxycholecalciferol, nephritogenoside nephritis was the most responsive condition [3].

High impact information on nephritogenoside

• In order to explain our findings, we have studied the glomerular and tubular expression of the 330 kD nephritogenic glycoprotein (gp330) as well as the corresponding antibody response [4].
• A method is described for the purification and identification of the nephritogenic glycoprotein in renal tubular epithelium (RTE-Gp) from Wistar and Lewis rats [5].
• Enzyme linked immunosorbent assay for Heymann's antigen as a contaminating minor component in nephritogenic glycopeptide, nephritogenoside [2].
• In the fraction of crude nephritogenoside which induced membranous glomerulonephritis (besides proliferative glomerulonephritis) in rats, both nephritogenoside and Heymann's antigen were detected by ELISA [2].
• Nephritogenoside is a minor component of the basement membrane of normal animals (including humans) [6].

Chemical compound and disease context of nephritogenoside

• Normal rat renal cortex contains three renal disease-inducing substances, that is, nephritogenoside, FX1A and immunogenoside (a novel renal glycoprotein that has the biological activity to induce only active Heymann nephritis) [7].

Anatomical context of nephritogenoside

• The antibody 14C1 recognized the previously described nephritogenic glycoprotein, gp 330, in microvillar brush border preparations, and reacted with material present on podocyte cell surfaces of normal rat kidneys, especially in coated pits, as well as with material in the glomerular deposits of rats with Heymann nephritis [8].
• Glomerular basement membrane (GBM) damage has been considered as the only source of the nephritogenic glycoprotein excreted in urine [9].
• Nephritogenoside was compared to other basement membrane components including collagenous and noncollagenous glycoproteins [10].

Gene context of nephritogenoside

• Nephritogenoside did not immunologically cross-react with laminin and fibronectin by direct or inhibition enzyme immunoassay [10].

Analytical, diagnostic and therapeutic context of nephritogenoside

• In addition to TCA treatment or DEAE-cellulose column chromatography, gel filtration on Bio-Gel P200 was a good tool for the removal of Heymann's antigen from nephritogenoside [2].

References