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Chemical Compound Review:

SureCN2509842 9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN3305072, AC1L3V1R, 9-deazainosine, 9-DI, 89458-19-5, ...

Bacchi, C.J. et al., Looker, D.L. et al., Fish, W.R. et al., Berman, J.D. et al., Marr, J.J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-.beta.-D-ribofuranosyl-

Two of the six, 9-deazainosine and allopurinol ribonucleoside, had very little toxicity for mouse L cells and offer promise as potential chemotherapeutic agents [1].
Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis [2].
The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day [3].

High impact information on 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-.beta.-D-ribofuranosyl-

In this study the activities of 9-deazainosine (9-DINO), formycin B, and sinefungin were compared in experimental murine Trypanosoma brucei subsp. brucei infections, both singly and in combination with the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine (DFMO, eflornithine) [2].
The antileishmanial agents allopurinol riboside, formycin B, 9-deazainosine, and sodium stibogluconate effectively inhibited the growth of L. donovani amastigotes in this cell line [4].
To study the capability of amastigotes in the U937 cell line to carry out biochemical reactions that could be monitored experimentally, we incubated the cells with radiolabeled 9-deazainosine [4].
Unlike formycin B, 9-deazainosine is not known to be aminated by mammalian cells and appears to be relatively nontoxic in three different mammalian tissue culture systems [5].
Growth inhibition studies were performed with three inosine analogs (allopurinol riboside, formycin B, and 9-deazainosine) on trypomastigotes grown in bone marrow tissue culture [5].

Gene context of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-.beta.-D-ribofuranosyl-

Formycin B [9-deazainosine] was reacted with epoxy-activated Sepharose 6B to form an affinity resin for purine nucleoside phosphorylase (PNPase) [6].

Analytical, diagnostic and therapeutic context of 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-.beta.-D-ribofuranosyl-

After 8 wk of immunosuppression, rats that developed severe Pneumocystis carinii pneumonia were treated with either 9-deazainosine or served as controls [7].

References

Biological action of inosine analogs in Leishmania and Trypanosoma spp. Marr, J.J., Berens, R.L., Cohn, N.K., Nelson, D.J., Klein, R.S. Antimicrob. Agents Chemother. (1984) [Pubmed]
Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis. Bacchi, C.J., Berens, R.L., Nathan, H.C., Klein, R.S., Elegbe, I.A., Rao, K.V., McCann, P.P., Marr, J.J. Antimicrob. Agents Chemother. (1987) [Pubmed]
Activity of purine analogs against Leishmania donovani in vivo. Berman, J.D., Hanson, W.L., Lovelace, J.K., Waits, V.B., Jackson, J.E., Chapman, W.L., Klein, R.S. Antimicrob. Agents Chemother. (1987) [Pubmed]
Growth of Leishmania donovani amastigotes in the continuous human macrophage cell line U937: studies of drug efficacy and metabolism. Looker, D.L., Martinez, S., Horton, J.M., Marr, J.J. J. Infect. Dis. (1986) [Pubmed]
Inosine analogs as chemotherapeutic agents for African trypanosomes: metabolism in trypanosomes and efficacy in tissue culture. Fish, W.R., Marr, J.J., Berens, R.L., Looker, D.L., Nelson, D.J., LaFon, S.W., Balber, A.E. Antimicrob. Agents Chemother. (1985) [Pubmed]
Purine nucleoside phosphorylase: purification using an ether-linked formycin B/sepharose 6B resin with unusual properties. Hall, W.W., Krenitsky, T.A. Prep. Biochem. (1990) [Pubmed]
Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats. Smith, J.W., Bartlett, M.S., Queener, S.F., Durkin, M.M., Jay, M.A., Hull, M.T., Klein, R.S., Marr, J.J. Diagn. Microbiol. Infect. Dis. (1987) [Pubmed]

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