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Chemical Compound Review

AmbotzBAA0030     ethyl (2S)-2-benzamido-5...

Synonyms: SureCN80453, CHEMBL2323122, AC1L3XGY, AR-1I9897, AC1Q5JT0, ...
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High impact information on Benzoyl-L-arginine ethyl ester


Biological context of Benzoyl-L-arginine ethyl ester

  • Methylene blue (10(-5) M), hemoglobin (10(-5) M) and NG-mono-methyl-L-arginine (5 mumol) antagonized the vasodilation elicited by infusion of BAEE [3].

Anatomical context of Benzoyl-L-arginine ethyl ester

  • Two types of PAD (HL-60 cell and brain PAD) could be distinguished by differential competition, using either BAEE or Bz-L-Arg as a preferential substrate in the assay [5].

Associations of Benzoyl-L-arginine ethyl ester with other chemical compounds

  • Chickens (Gallus domesticus) were protected from the acute gamma-irradiation-induced mortality (within 24 hours) by the proteolytic enzyme inhibitors, soy-bean trypsin inhibitor (SBTI), lima bean inhibitor (LBTI), antipain, alpha-N-benzoyl-L-arginine ethyl ester HCl (BAEE), trasylol, and leupeptin [6].

Gene context of Benzoyl-L-arginine ethyl ester

  • One mg of the preparation inhibited 67 KU and the hydrolysis of 5.8 micronmoles/min of BAEE by hog pancreatic kallikrein [EC] [7].
  • PRP has also proved to be active on synthetic substrates of proteolytic enzymes such as p-Tosyl-L-arginine methyl ester-HCl (TAME), alpha-N-benzoyl-L-arginine ethyl ester-HCl (BAEE), and alpha-N-benzoyl-DL-arginine-p-nitroanilide HCl (BAPNA) [8].
  • Trypsin inhibitory effect of PMCP nanoparticles was evaluated using N-alpha-benzoyl-l-arginine ethyl ester (BAEE) and casein as substrates [9].
  • At specified time intervals, the sperm were separated from the incubation medium by centrifugation, and the distribution of dipeptidyl peptidase (DPP II) and acrosin activity was determined by biochemically assaying the hydrolysis of trialanine and N-benzoyl-L-arginine ethyl ester (BAEE), respectively [10].


  1. Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing. Helgason, C.D., Atkinson, E.A., Pinkoski, M.J., Bleackley, R.C. Exp. Cell Res. (1995) [Pubmed]
  2. Characterization of soybean trypsin inhibitor sensitive protease from unfertilized sea urchin eggs. Alliegro, M.C., Schuel, H. Biochemistry (1985) [Pubmed]
  3. Endothelium-mediated effects of N-substituted arginines on the isolated perfused rat kidney. Farhat, M.Y., Ramwell, P.W., Thomas, G. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  4. Purification and properties of a serine protease from Pseudomonas matophilia. Boethling, R.S. J. Bacteriol. (1975) [Pubmed]
  5. A highly sensitive high-performance liquid chromatography-- fluorometric method for the assay of peptidylarginine deiminase activity. Chikuma, T., Yamada, M., Tsuda, A., Yamamoto, M., Nakashima, K., Yajima, R., Kato, T. Anal. Biochem. (2000) [Pubmed]
  6. gamma-Irradiation-induced mortality: protective effect of protease inhibitors in chickens and mice. Palladino, M.A., Galton, J.E., Troll, W., Thorbecke, G.J. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1982) [Pubmed]
  7. Kallikrein inhibitors in rat plasma. Hojima, Y., Isobe, M., Moriya, H. J. Biochem. (1977) [Pubmed]
  8. Properties of an oviducal protein involved in amphibian oocyte fertilization. Miceli, D.C., Fernandez, S.N. J. Exp. Zool. (1982) [Pubmed]
  9. Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Sajeesh, S., Sharma, C.P. International journal of pharmaceutics. (2006) [Pubmed]
  10. Evidence for sequential deployment of secretory enzymes during the normal acrosome reaction of guinea pig sperm in vitro. DiCarlantonio, G., Talbot, P. Gamete research. (1988) [Pubmed]
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