Disease relevance of Canavalmine

• Canavalmine exerted an inhibition on murine erythroleukemia cell growth at concentrations over 50 microM [1].

High impact information on Canavalmine

• Occurrence of aminopropylhomospermidine and canavalmine in the hamster epididymis [2].
• The canavalmine-induced cell differentiation was inhibited by the addition of agents which alter the structure of the cell membrane, such as local anesthetics (procainamide and lidocaine) or Ca2+ antagonists (nifedipine and verapamil) at dosages not toxic for the cell growth [3].
• Erythroid differentiation of cultured murine erythroleukemia cells by the spermine analogue canavalmine [3].
• The results suggest that the growth-inhibitory action of canavalmine on murine erythroleukemia cells is most likely due to an inhibition of early events of the cell cycle, possibly due to the interference of a structure-specific function of spermidine and/or spermine on DNA replication [1].
• The degree of growth inhibition by canavalmine during the cell cycle was examined using synchronized cells [1].

Chemical compound and disease context of Canavalmine

• The effects of canavalmine, a structural analogue of spermine, were studied in cultured murine erythroleukemia cells 745A [1].

Biological context of Canavalmine

• The cell proliferation was, however, restored when canavalmine was removed from the culture medium after 24 h [1].
• Serum-induced growth stimulation was inhibited by canavalmine most effectively in the cells at G1 phase prior to DNA synthesis [1].

Analytical, diagnostic and therapeutic context of Canavalmine

• In the present study two other polyamines were identified in adult hamster epididymis by gas chromatography; they are aminopropylhomospermidine [NH2(CH2)3NH(CH2)4NH(CH2)4NH2] and canavalmine [NH2(CH2)4NH(CH2)3NH(CH2)4NH2] [2].

References