High impact information on C08448

• It is concluded that eutypine uncouples mitochondrial oxidative phosphorylation and decreases the ADP/O ratio in grapevine cells by increasing the proton leaks via a cyclic protonophore mechanism [1].
• Protonophoric activity of eutypine, a toxin from Eutypa lata, in plant mitochondria [1].
• For high eutypine concentrations, a mixed effect corresponding to a direct inhibition of electron transport and uncoupling can be observed [1].
• Eutypine induces marked stimulation of oxygen consumption and a depolarizing effect, while methyl-eutypine exhibits a very small effect on both the rate of oxygen uptake and membrane potential [1].
• Control of anthocyanin biosynthesis pathway gene expression by eutypine, a toxin from Eutypa lata, in grape cell tissue cultures [2].

Biological context of C08448

• Six compounds were generally produced in significant amounts, namely eutypinol, eulatachromene, and eutypine and its benzofuran cyclization product, together with siccayne and eulatinol [3].

Associations of C08448 with other chemical compounds

• Neither eutypinol nor siccayne were phytotoxic; eulatachromene, eulatinol, eutypine, and the benzofuran exhibited necrotic effects in the bioassay [3].

Analytical, diagnostic and therapeutic context of C08448

• Expression of CHS, F3H, DFR and LDOXwas not affected by the addition of eutypine to grapevine cell cultures [2].
• HPLC analysis showed that eutypinol was consistently produced in large amounts, together with smaller amounts of methyleutypinol and eulatachromene; eutypine, the putative toxin, was produced solely on Sauvignon Blanc extract and then in only barely detectable amounts [4].

References