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Chemical Compound Review

Zincov     N-[(1S)-1- (aminocarbonylmethylcarbamoyl) et...

Synonyms: AC1L2XLV, AC1Q5QBY, AR-1K3733, HC-MP-Ala-glynh2
 
 
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High impact information on Zincov

  • Western blot analysis showed that occludin bands of 66-85 kDa were digested by HA/P to two predominant bands of around 50 kDa and 35 kDa, and that this degradation was greatly attenuated when the specific bacterial metalloproteinase inhibitor Zincov was co-administered [1].
  • Substitution mutations within the consensus active-site residues completely abolish all in vitro catalytic functions, as does addition of 1,10-phenanthroline, EDTA, and certain amino acid hydroxamates, including the novel zinc metalloprotease inhibitor ZINCOV [2].
  • This activity is inhibited by Zincov, which does not affect the hemagglutination activity of trypsin and pronase [3].
  • Likewise, ic injection of another neutral endopeptidase-24.11 inhibitor Zincov (200 nmol) produced a 63% inhibition in gastric acid output [4].
  • It has a molecular mass of 35 kDa, isoelectric points of 3.5 and 3.7, and is inhibited by ortho-phenanthro line, phosphoramidon, and Zincov [5].
 

Biological context of Zincov

  • Treatment with metalloprotease inhibitor, Zincov, produced dose-dependent reduction (56.9%) in aspirin-induced increase in the mucosal expression of soluble TNF-alpha, evoked a 62% decrease in the rate of epithelial cell apoptosis, and led to a marked reversal (56.9%) in aspirin-induced delay in ulcer healing [6].
 

Gene context of Zincov

  • This shock was prevented either with a specific elastase inhibitor, HONHCOCH(CH2C6H5)CO-Ala-Gly-NH2, zincov (6 microM), or with human alpha 2M [7].
  • Inhibition of the filtrate metalloproteinase by Zincov and alpha 2-macroglobulin significantly (P less than 0.005) reduced the ability of cholera filtrate to degrade mucin or to stimulate mucin secretion from rat intestinal slices in vitro [8].

References

  1. Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Wu, Z., Nybom, P., Magnusson, K.E. Cell. Microbiol. (2000) [Pubmed]
  2. Lethal factor active-site mutations affect catalytic activity in vitro. Hammond, S.E., Hanna, P.C. Infect. Immun. (1998) [Pubmed]
  3. Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme. Booth, B.A., Boesman-Finkelstein, M., Finkelstein, R.A. Infect. Immun. (1983) [Pubmed]
  4. Intracisternal neutral endopeptidase-24.11 inhibitors produce inhibition in gastric acid output: independence from opiate, bombesin, or neurotensin-mediated mechanisms. Stephens, R.L., LePard, K.J., Mohammed, J.R., Ward, P.E. Regul. Pept. (1993) [Pubmed]
  5. Isolation and characterization of a zinc-containing metalloprotease expressed by Vibrio tubiashii. Delston, R.B., Kothary, M.H., Shangraw, K.A., Tall, B.D. Can. J. Microbiol. (2003) [Pubmed]
  6. Aspirin ingestion impairs oral mucosal ulcer healing by inducing membrane-bound tumor necrosis factor-alpha release. Slomiany, B.L., Slomiany, A. IUBMB Life (2000) [Pubmed]
  7. Role of alpha-2-macroglobulin and bacterial elastase in guinea-pig pseudomonal septic shock. Khan, M.M., Shibuya, Y., Kambara, T., Yamamoto, T. International journal of experimental pathology. (1995) [Pubmed]
  8. Vibrio cholerae metalloproteinase degrades intestinal mucin and facilitates enterotoxin-induced secretion from rat intestine. Crowther, R.S., Roomi, N.W., Fahim, R.E., Forstner, J.F. Biochim. Biophys. Acta (1987) [Pubmed]
 
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