The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tocris-0781     N-[4-[[5-[3-(2-aminoethyl)- 1H-indol-5-yl]...

Synonyms: CHEMBL39317, SureCN1321182, ANW-60396, BPBio1_000001, CTK8B8457, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on L-694247


Biological context of L-694247


Anatomical context of L-694247

  • L694247 caused little or no stimulation of [35S]GTPgammaS binding in brain regions with high densities of 5-HT(1B/D) binding sites (e.g., substantia nigra, striatum, central gray, and dorsal subiculum) [1].
  • Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats [5].
  • A recently identified endogenous tetrapeptide, 5-HT-moduline (Leu-Ser-Ala-Leu, LSAL), which specifically antagonizes 5-HT1B/1D receptor activity, was also shown to reverse the stimulating action of L-694,247 on T cell proliferation [6].

Associations of L-694247 with other chemical compounds

  • The effects of L-694,247 are due to a specific interaction with 5-HT1D receptors, because its inhibitory effect on water intake in dehydrated rats is blocked by the previous administration of a 5-HT1D antagonist, GR 127935 (5 micrograms/rat), directly into the third ventricle [5].

Gene context of L-694247


  1. Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding. Dupuis, D.S., Palmier, C., Colpaert, F.C., Pauwels, P.J. J. Neurochem. (1998) [Pubmed]
  2. Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling. Heusler, P., Pauwels, P.J., Wurch, T., Newman-Tancredi, A., Tytgat, J., Colpaert, F.C., Cussac, D. Neuropharmacology (2005) [Pubmed]
  3. Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgammaS-binding responses in the human and monkey brain. Dupuis, D.S., Pauwels, P.J., Radu, D., Hall, H. Eur. J. Neurosci. (1999) [Pubmed]
  4. On the role of 5-HT1B/1D receptors in modulating transmission in a spinal reflex pathway in the decerebrated rabbit. Ogilvie, J., Wigglesworth, M., Appleby, L., Kingston, T.O., Clarke, R.W. Br. J. Pharmacol. (1999) [Pubmed]
  5. Effect of third ventricle administration of L-694,247, a selective 5-HT1D receptor agonist, on water intake in rats. De Castro-e-Silva, E., Sarmento, C., Nascimento, T.A., Luz, C.P., Soares, T., Marinho, A., Cunha, M., Bulcäo, C., De Oliveira, I.R., Fregoneze, J.B. Pharmacol. Biochem. Behav. (1997) [Pubmed]
  6. The proliferation of human T lymphoblastic cells induced by 5-HT1B receptors activation is regulated by 5-HT-moduline. Sibella-Argüelles, C. C. R. Acad. Sci. III, Sci. Vie (2001) [Pubmed]
  7. L-694,247: a potent 5-HT1D receptor agonist. Beer, M.S., Stanton, J.A., Bevan, Y., Heald, A., Reeve, A.J., Street, L.J., Matassa, V.G., Hargreaves, R.J., Middlemiss, D.N. Br. J. Pharmacol. (1993) [Pubmed]
  8. In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking. Querejeta, E., Oviedo-Chávez, A., Araujo-Alvarez, J.M., Quiñones-Cárdenas, A.R., Delgado, A. Brain Res. (2005) [Pubmed]
WikiGenes - Universities