Disease relevance of Iron ore

• When B[a]P was adsorbed on haematite particles, both its retention in the respiratory tract and pulmonary toxicity increased [1].
• The study found an excess risk of non-malignant respiratory disease and of lung cancer among haematite miners [2].
• Pneumoconiosis in the haematite iron ore mines of West Cumbria. A study of 45 years of control [3].
• Haematite-macrophage combinations produced no significant fibrosis [4].
• The occlusive and obliterative vascular changes in 'haematite lung' are in reality those of silicosis which are brought about by the inhalation of silica particles with the iron sesquioxide [5].

High impact information on Iron ore

• The Comet assay was first used to measure DNA damage in four isolated cell types from Sprague-Dawley rats at 1, 2, 4, 8 and 24h after in vitro treatment with hematite (Fe2O3) or B[a]P or B[a]P coated onto hematite [6].
• The UDS assay was used to measure DNA repair in two cell types (lung cells and hepatocytes) of OFA Sprague-Dawley rats, 24 h after endotracheal administration of a single dose of an iron oxide (hematite, Fe2O3) (0.75 mg), of B[a]P (0.75 mg) or of B[a]P (0.75 mg) coated on hematite particles (0.75 mg) [7].
• After phagocytosis of haematite particles, enlarged vacuoles containing the ingested material were visible within the cytoplasm of Kupffer cells while crescent-shaped vacuoles were no longer detectable [8].
• Analysis of crystals found at the interface between the hair and the skeletal neck vertebrae revealed a mixture of newberyite and haematite, associated with decomposition products of the hair and bone [9].
• A possible terrestrial analogue for haematite concretions on Mars [10].

Anatomical context of Iron ore

• The only feature peculiar to haematite lung is the intense accumulation of iron-containing dust in and around the pulmonary blood vessels [5].

Analytical, diagnostic and therapeutic context of Iron ore

• The mortality risk of iron ore (haematite) miners between 1970 and 1982 was investigated in a retrospective cohort study of workers from two mines, Longyan and Taochong, in China. The cohort was limited to men and consisted of 5406 underground miners and 1038 unexposed surface workers [2].
• The process that was chosen for conducting this test was the synthesis of spinel (MgAl2O4) using microwaves as a power supply and hematite (Fe2O3) as an additive for both spinel formation promotion and susceptor [11].

References