Disease relevance of Pneumoconiosis

• All causes of mortality were also significantly elevated (SMR = 2.19), largely because of the very high rate of deaths due to pneumoconioses (primarily beryllium disease) (SMR = 34.23; 158 deaths) [1].
• Despite suspicion that inhalation of zirconium should be capable of causing human pulmonary disease, documentation of zirconium pneumoconiosis in humans has been lacking [2].
• Our study population consisted of 25 patients with CWP (16 simple pneumoconiosis, SP, 9 progressive massive fibrosis, PMF, 9 control subjects, and 6 patients with idiopathic pulmonary fibrosis (IPF) [3].
• Dusts causing pneumoconiosis generate .OH and produce hemolysis by acting as Fenton catalysts [4].
• The most important long-term mortality risks for the white uranium-miners continue to be lung cancer and pneumoconioses, for which SMRs remain significantly elevated after a mean period of 22.4 years since last uranium mining [5].

High impact information on Pneumoconiosis

• Zinc and cadmium, other common causes of pneumoconiosis, had no effect on the water permeability of AQP3 [6].
• Serum immunoglobulins, rheumatoid factor, and pneumoconiosis in coal miners with rheumatoid arthritis [7].
• Secretion and mRNA expression of TNF alpha and IL-6 in the lungs of pneumoconiosis patients [8].
• Hydroxyl radical generation by coal mine dust: possible implication to coal workers' pneumoconiosis (CWP) [9].
• Moreover, in patients with pneumoconiosis, bronchiolar dysplasias exhibited p53 expression more frequently than bronchial dysplasias (13 of 23 vs. 4 of 19) [10].

Chemical compound and disease context of Pneumoconiosis

• Polyvinyl chloride pneumoconiosis [11].
• Nepheline rock dust pneumoconiosis. A report of 2 cases [12].
• Four men who mined barytes in Scotland and who developed pneumoconiosis are described [13].
• Pathology of silicon carbide pneumoconiosis [14].
• An association between PVC dust and pneumoconiosis also has been demonstrated [15].

Biological context of Pneumoconiosis

• Nepheline rock dust pneumoconiosis should be considered when the above radiological changes are observed and an occupational exposure to inorganic dust is documented [12].
• Pulmonary diffusing capacity for carbon monoxide in simple coal workers' pneumoconiosis [16].
• OBJECTIVE: To compare nasal mucociliary clearance (NMC) functions in coal workers with pneumoconiosis, coal workers without pneumoconiosis and healthy controls by using technetium-99m-labeled macroaggregated albumin rhinoscintigraphy [17].
• The interest of these studies is not limited to asbestos related pathologies, but they have also contributed to a better diagnosis and understanding of the pathogenesis of unusual pneumoconiosis like aluminium induced interstitial lung disease and dental technicians pneumoconiosis [18].

Anatomical context of Pneumoconiosis

• In this paper, two hypotheses implicitly generated by recent findings were tested in two case-control studies among coal miners: generation of tumour necrosis factor (TNF) by blood monocytes of miners with coal workers' pneumoconiosis (CWP) and serum type III procollagen peptide (PIIIP) in CWP [19].
• In order to investigate occupational diseases related to welding fume exposure, such as nasal septum perforation, pneumoconiosis and manganese intoxication, we built a welding fume exposure system that included a welding fume generator, exposure chamber and fume collector [20].
• The level of TNF-alpha and IL-8 in blood serum was higher in subjects with pneumoconiosis than in controls [21].
• Aspergillus fumigatus Asp fI DNA is prevalent in sputum from patients with coal workers' pneumoconiosis [22].
• Decreased glutathione content and glutathione S-transferase activity in red blood cells of coal miners with early stages of pneumoconiosis [23].

Gene context of Pneumoconiosis

• Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and their soluble receptors in coal workers' pneumoconiosis [24].
• Our findings indicate that chemokine receptors CCR5 and CX3CR1 may be involved in the development of pneumoconiosis [25].
• Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis [25].
• The frequency of cyclin D1 expression proved to be significantly higher in chromate-induced SCCs than in SCCs from nonexposed individuals and from those with pneumoconiosis (P < .001) [26].
• The increase in glutathione peroxidase activity in the plasma of retired miners with pneumoconiosis may be the result of a response to the increasing hydrogen peroxide (H2O2) production due to the disease process [27].

Analytical, diagnostic and therapeutic context of Pneumoconiosis

• Epidemiological study of pneumoconiosis in the Italian poly(vinyl chloride) industry [28].
• Gallium 67 scintigraphy is employed in the evaluation of workers with possible pneumoconiosis [29].
• CONCLUSION: The VE/VO(2) ratio as a measurement of mismatch between ventilation and perfusion predicted the clinical grade of breathlessness better than measurements of bronchial obstruction at rest in coal workers with pneumoconiosis [30].

References