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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Silicosis


High impact information on Silicosis


Chemical compound and disease context of Silicosis


Biological context of Silicosis

  • Because p53 is a key transcription factor regulating many important apoptosis-related genes, we hypothesized that p53 may play a key role in silica-induced apoptosis and that abnormal regulation of p53 by silica may contribute to development of lung cancer as well as silicosis [16].
  • To address these specific aims, we compared levels of IgG and IgM in serum and BAL from rats with experimental silicosis induced by inhalation of silica with levels of these immunoglobulins in titanium dioxide (TiO(2))- and sham (air)-exposed controls [17].
  • By summarizing these results, the activity of telomerase is thought to be a very sensitive marker for the evaluation of pathogenicity, showing cellular immortalization in an experimental silicosis model [18].
  • We conclude that silicosis without associated COLD leads to mineral hemodynamic impairment at rest and during exercise, and that airway resistance does not detect impairment of flow as effectively as FEV 1.0 reduction [19].
  • Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients [20].

Anatomical context of Silicosis


Gene context of Silicosis

  • In the present study, we further dissect the exact functions of IL-10 in experimental silicosis [26].
  • We conclude that the major gene for silicosis may be mapped near the HLA-B locus [27].
  • Surfactant-associated proteins (SP-A, SP-B) are increased proportionally to alveolar phospholipids in sheep silicosis [28].
  • CONCLUSION : The axis of IL-12 driving IFN-gamma production is not essential for the full manifestations of silicosis in mice exposed to a crystobalite silica aerosol [29].
  • Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles [30].

Analytical, diagnostic and therapeutic context of Silicosis


  1. Transforming growth factor-beta (TGF-beta) in silicosis. Jagirdar, J., Begin, R., Dufresne, A., Goswami, S., Lee, T.C., Rom, W.N. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  2. Lung cancer in relation to exposure to silica dust, silicosis and uranium production in South African gold miners. Hnizdo, E., Murray, J., Klempman, S. Thorax (1997) [Pubmed]
  3. Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz). Williams, A.O., Knapton, A.D., Ifon, E.T., Saffiotti, U. Int. J. Cancer (1996) [Pubmed]
  4. Serum levels of soluble Fas ligand in patients with silicosis. Tomokuni, A., Otsuki, T., Isozaki, Y., Kita, S., Ueki, H., Kusaka, M., Kishimoto, T., Ueki, A. Clin. Exp. Immunol. (1999) [Pubmed]
  5. Intramolecular epitope spreading among anti-caspase-8 autoantibodies in patients with silicosis, systemic sclerosis and systemic lupus erythematosus, as well as in healthy individuals. Ueki, A., Isozaki, Y., Tomokuni, A., Hatayama, T., Ueki, H., Kusaka, M., Shiwa, M., Arikuni, H., Takeshita, T., Morimoto, K. Clin. Exp. Immunol. (2002) [Pubmed]
  6. Fas ligand triggers pulmonary silicosis. Borges, V.M., Falcão, H., Leite-Júnior, J.H., Alvim, L., Teixeira, G.P., Russo, M., Nóbrega, A.F., Lopes, M.F., Rocco, P.M., Davidson, W.F., Linden, R., Yagita, H., Zin, W.A., DosReis, G.A. J. Exp. Med. (2001) [Pubmed]
  7. Lung cancer mortality and silicosis in Québec, 1938-85. Infante-Rivard, C., Armstrong, B., Petitclerc, M., Cloutier, L.G., Theriault, G. Lancet (1989) [Pubmed]
  8. Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis. Gambelli, F., Di, P., Niu, X., Friedman, M., Hammond, T., Riches, D.W., Ortiz, L.A. J. Biol. Chem. (2004) [Pubmed]
  9. Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica. Gossart, S., Cambon, C., Orfila, C., Séguélas, M.H., Lepert, J.C., Rami, J., Carré, P., Pipy, B. J. Immunol. (1996) [Pubmed]
  10. Increased elastin production in experimental granulomatous lung disease. Mariani, T.J., Crouch, E., Roby, J.D., Starcher, B., Pierce, R.A. Am. J. Pathol. (1995) [Pubmed]
  11. Radiographic evidence of silicosis risk in the diatomaceous earth industry. Hughes, J.M., Weill, H., Checkoway, H., Jones, R.N., Henry, M.M., Heyer, N.J., Seixas, N.S., Demers, P.A. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  12. Mast cell basic fibroblast growth factor in silicosis. Hamada, H., Vallyathan, V., Cool, C.D., Barker, E., Inoue, Y., Newman, L.S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  13. Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Ortiz, L.A., Lasky, J., Gozal, E., Ruiz, V., Lungarella, G., Cavarra, E., Brody, A.R., Friedman, M., Pardo, A., Selman, M. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  14. Enhanced release of prostaglandin E2 from macrophages of rats with silicosis. Mohr, C., Davis, G.S., Graebner, C., Hemenway, D.R., Gemsa, D. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  15. Reduced release of leukotrienes B4 and C4 from alveolar macrophages of rats with silicosis. Mohr, C., Davis, G.S., Graebner, C., Amann, S., Hemenway, D.R., Gemsa, D. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  16. Essential role of p53 in silica-induced apoptosis. Wang, L., Bowman, L., Lu, Y., Rojanasakul, Y., Mercer, R.R., Castranova, V., Ding, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  17. Immunoglobulin responses to experimental silicosis. Huang, S.H., Hubbs, A.F., Stanley, C.F., Vallyathan, V., Schnabel, P.C., Rojanasakul, Y., Ma, J.K., Banks, D.E., Weissman, D.N. Toxicol. Sci. (2001) [Pubmed]
  18. Activation of telomerase by silica in rat lung. Kim, J.K., Lim, Y., Kim, K.A., Seo, M.S., Kim, J.D., Lee, K.H., Park, C.Y. Toxicol. Lett. (2000) [Pubmed]
  19. Cardiopulmonary adaptation to exercise in coal miners. Scano, G., Garcia-Herreros, P., Stendardi, D., Degre, S., De Coster, A., Sergysels, R. Arch. Environ. Health (1980) [Pubmed]
  20. Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients. Ueki, A., Isozaki, Y., Tomokuni, A., Tanaka, S., Otsuki, T., Kishimoto, T., Kusaka, M., Aikoh, T., Sakaguchi, H., Hydoh, F. Sci. Total Environ. (2001) [Pubmed]
  21. Anti-topoisomerase I antibodies in silica-associated systemic sclerosis. A model for autoimmunity. McHugh, N.J., Whyte, J., Harvey, G., Haustein, U.F. Arthritis Rheum. (1994) [Pubmed]
  22. Fibroblast tropoelastin and alpha-smooth-muscle actin expression are repressed by particulate-activated macrophage-derived tumor necrosis factor-alpha in experimental silicosis. Mariani, T.J., Arikan, M.C., Pierce, R.A. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  23. Experimental silicosis: a shift to a preferential IFN-gamma-based Th1 response in thoracic lymph nodes. Garn, H., Friedetzky, A., Kirchner, A., Jäger, R., Gemsa, D. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  24. Induction of CD69 antigen expression in peripheral blood mononuclear cells on exposure to silica, but not by asbestos/chrysotile-A. Wu, P., Hyodoh, F., Hatayama, T., Sakaguchi, H., Hatada, S., Miura, Y., Takata-Tomokuni, A., Katsuyama, H., Otsuki, T. Immunol. Lett. (2005) [Pubmed]
  25. Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. Hamzaoui, A., Ammar, J., Graïri, H., Hamzaoui, K. Mediators of inflammation. (2003) [Pubmed]
  26. Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice. Barbarin, V., Arras, M., Misson, P., Delos, M., McGarry, B., Phan, S.H., Lison, D., Huaux, F. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  27. Immunogenetic analysis of silicosis in Japan. Honda, K., Kimura, A., Dong, R.P., Tamai, H., Nagato, H., Nishimura, Y., Sasazuki, T. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
  28. Surfactant-associated proteins (SP-A, SP-B) are increased proportionally to alveolar phospholipids in sheep silicosis. Lesur, O., Veldhuizen, R.A., Whitsett, J.A., Hull, W.M., Possmayer, F., Cantin, A., Bégin, R. Lung (1993) [Pubmed]
  29. Interleukin-12 is not essential for silicosis in mice. Davis, G.S., Pfeiffer, L.M., Hemenway, D.R., Rincon, M. Particle and fibre toxicology [electronic resource]. (2006) [Pubmed]
  30. Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. Ueki, A., Isozaki, Y., Kusaka, M. Journal of occupational health. (2005) [Pubmed]
  31. Crystalline silica exposure, radiological silicosis, and lung cancer mortality in diatomaceous earth industry workers. Checkoway, H., Hughes, J.M., Weill, H., Seixas, N.S., Demers, P.A. Thorax (1999) [Pubmed]
  32. Relationship between silicosis and rheumatoid arthritis. Sluis-Cremer, G.K., Hessel, P.A., Hnizdo, E., Churchill, A.R. Thorax (1986) [Pubmed]
  33. Detection, epitope-mapping and function of anti-Fas autoantibody in patients with silicosis. Takata-Tomokuni, A., Ueki, A., Shiwa, M., Isozaki, Y., Hatayama, T., Katsuyama, H., Hyodoh, F., Fujimoto, W., Ueki, H., Kusaka, M., Arikuni, H., Otsuki, T. Immunology (2005) [Pubmed]
  34. Risk of silicosis in cohorts of Chinese tin and tungsten miners, and pottery workers (I): an epidemiological study. Chen, W., Hnizdo, E., Chen, J.Q., Attfield, M.D., Gao, P., Hearl, F., Lu, J., Wallace, W.E. Am. J. Ind. Med. (2005) [Pubmed]
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