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Chemical Compound Review

Lauricidin     2,3-dihydroxypropyl dodecanoate

Synonyms: Monolaurin, Lauricidin R, Lauricidin 802, Lauricidin 812, Glycerox L 8, ...
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Disease relevance of lauric acid glyceryl ester


High impact information on lauric acid glyceryl ester

  • The fully saturated analogue 1-monoarachidin did not inhibit the enzyme, whereas the lower side chain analogues 1-monopalmitin and 1-monomyristin inhibited the enzyme with IC50 values of 12 and 32 microM, respectively [5].
  • With GMDD only, a trend of increasing bioavailability with increasing monoglyceride concentration was observed, which may be explained by its limited aqueous solubility [6].
  • Because of their longstanding safety record, origanum and/or monolaurin, alone or combined with antibiotics, might prove useful in the prevention and treatment of severe bacterial infections, especially those that are difficult to treat and/or are antibiotic resistant [3].
  • In addition, various combinations of nisin, lysozyme, and monolaurin with EDTA were bactericidal to some gram-negative bacteria whereas none of the antimicrobials alone were bactericidal [4].
  • The lactoperoxidase system (LPS) and monolaurin (ML) are potential natural antimicrobial agents for use in foods [7].

Chemical compound and disease context of lauric acid glyceryl ester

  • None of the lipids showed significant antibacterial activity against Salmonella spp. and E. coli but eight of 12 lipids tested showed high activity against H. pylori, monocaprin and monolaurin being the most active [8].

Anatomical context of lauric acid glyceryl ester


Associations of lauric acid glyceryl ester with other chemical compounds


Gene context of lauric acid glyceryl ester

  • Brine shrimp lethality-directed fractionation of the 95% EtOH extract of the powdered, dried berries of Serenoa repens (Bart.) Small (saw-palmetto) (Palmae) led to the isolation of two monoacylglycerides, 1-monolaurin (1) and 1-monomyristin (2) [11].

Analytical, diagnostic and therapeutic context of lauric acid glyceryl ester

  • Results were analysed using the Response Surface Methodology (RSM) and indicated that nisin and monolaurin had no action on spores before germination; only pH values had a significant effect (P < or = 0.001), i.e. spore count decreased as the pH value increased in relation to germination [12].


  1. Dodecylglycerol. A new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790. Ved, H.S., Gustow, E., Mahadevan, V., Pieringer, R.A. J. Biol. Chem. (1984) [Pubmed]
  2. Two-enzyme system for the synthesis for 1-lauroyl-rac-glycerophosphate (lysophosphatidic acid) and 1-lauroyl-dihydroxyacetonephosphate. Virto, C., Adlercreutz, P. Chem. Phys. Lipids (2000) [Pubmed]
  3. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Preuss, H.G., Echard, B., Enig, M., Brook, I., Elliott, T.B. Mol. Cell. Biochem. (2005) [Pubmed]
  4. Enhancement of nisin, lysozyme, and monolaurin antimicrobial activities by ethylenediaminetetraacetic acid and lactoferrin. Branen, J.K., Davidson, P.M. Int. J. Food Microbiol. (2004) [Pubmed]
  5. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Vandevoorde, S., Saha, B., Mahadevan, A., Razdan, R.K., Pertwee, R.G., Martin, B.R., Fowler, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats. Watanabe, Y., van Hoogdalem, E.J., de Boer, A.G., Breimer, D.D. Journal of pharmaceutical sciences. (1988) [Pubmed]
  7. Inhibition of bacterial foodborne pathogens by the lactoperoxidase system in combination with monolaurin. McLay, J.C., Kennedy, M.J., Orourke, A.L., Elliot, R.M., Simmonds, R.S. Int. J. Food Microbiol. (2002) [Pubmed]
  8. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. Bergsson, G., Steingrímsson, O., Thormar, H. Int. J. Antimicrob. Agents (2002) [Pubmed]
  9. Effect of triglyceride on small intestinal absorption of cefoxitin in rats. Yoshitomi, H., Nishihata, T., Frederick, G., Dillsaver, M., Higuchi, T. J. Pharm. Pharmacol. (1987) [Pubmed]
  10. Effect of antimicrobial factors in human milk on rhinoviruses and milk-borne cytomegalovirus in vitro. Clarke, N.M., May, J.T. J. Med. Microbiol. (2000) [Pubmed]
  11. Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens). Shimada, H., Tyler, V.E., McLaughlin, J.L. J. Nat. Prod. (1997) [Pubmed]
  12. Inhibition of Bacillus licheniformis spore growth in milk by nisin, monolaurin, and pH combinations. Mansour, M., Amri, D., Bouttefroy, A., Linder, M., Milliere, J.B. J. Appl. Microbiol. (1999) [Pubmed]
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