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Chemical Compound Review

SureCN41266     (2S)-2-amino-3-(5-methyl-1H- indol-3...

Synonyms: AG-E-01892, CHEBI:52527, KB-43805, CTK0E7916, LS-158155, ...
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Disease relevance of L-5-Methyltryptophan


High impact information on L-5-Methyltryptophan


Biological context of L-5-Methyltryptophan


Anatomical context of L-5-Methyltryptophan

  • To increase the specific free amino acid content in the japonica rice (Oryza sativa L.) cultivar Donganbyeo, mutant cell lines resistant to growth inhibition by 5-methyltryptophan (5MT) were selected from embryo-cultured callus irradiated with 50 Gy gamma-rays [11].

Associations of L-5-Methyltryptophan with other chemical compounds


Gene context of L-5-Methyltryptophan


  1. Anthranilate synthase from Ruta graveolens. Duplicated AS alpha genes encode tryptophan-sensitive and tryptophan-insensitive isoenzymes specific to amino acid and alkaloid biosynthesis. Bohlmann, J., Lins, T., Martin, W., Eilert, U. Plant Physiol. (1996) [Pubmed]
  2. Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase. O'Gara, J.P., Dunican, L.K. Appl. Environ. Microbiol. (1995) [Pubmed]
  3. Mutagenic activity of cyclophosphamide, ifosfamide, and trofosfamide in different genes of escherichia coli and salmonella typhimurium after biotransformation through extracts of rodent liver. Ellenberger, J., Mohn, G. Arch. Toxicol. (1975) [Pubmed]
  4. Characterization of the Bacillus subtilis tryptophan promoter region. Shimotsu, H., Henner, D.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Protein folding within the cell is influenced by controlled rates of polypeptide elongation. Crombie, T., Swaffield, J.C., Brown, A.J. J. Mol. Biol. (1992) [Pubmed]
  6. Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding. Shan, X., Gardner, K.H., Muhandiram, D.R., Kay, L.E., Arrowsmith, C.H. J. Biomol. NMR (1998) [Pubmed]
  7. Isolation of a cDNA for tryptophan synthase beta from rice and studies of its expression in a 5-methyltryptophan-resistant mutant of rice. Kisaka, H., Kisaka, M., Lee, H.Y., Kameya, T. Plant Mol. Biol. (1998) [Pubmed]
  8. Characterization of mutations in the penicillinase operon Staphylococcus aureus. Imsande, J., Lilleholm, J.L. Mol. Gen. Genet. (1976) [Pubmed]
  9. NMR studies of the activation of the Escherichia coli trp repressor. Hyde, E.I., Ramesh, V., Frederick, R., Roberts, G.C. Eur. J. Biochem. (1991) [Pubmed]
  10. A sequence from a tryptophan-hyperproducing strain of Corynebacterium glutamicum encoding resistance to 5-methyltryptophan. Heery, D.M., Fitzpatrick, R., Dunican, L.K. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  11. Development of AFLP-derived STS markers for the selection of 5-methyltryptophan-resistant rice mutants. Kim, D.S., Lee, I.S., Jang, C.S., Kang, S.Y., Song, H.S., Lee, Y.I., Seo, Y.W. Plant Cell Rep. (2004) [Pubmed]
  12. Cloning, nucleotide sequence, and characterization of mtr, the structural gene for a tryptophan-specific permease of Escherichia coli K-12. Heatwole, V.M., Somerville, R.L. J. Bacteriol. (1991) [Pubmed]
  13. A mutation to 5-methyltryptophan dependence in the tryptophan (trp) operon of Salmonella typhimurium. II. Studies of 5-methyltryptophan-dependent mutants and their revertants. Callahan, R., Dooley, M.M. Mol. Gen. Genet. (1978) [Pubmed]
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