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Chemical Compound Review:

Tocris-1224 2-diphenylboranyloxyethanamine

Synonyms: D9754_ALDRICH, CHEMBL169233, SureCN341835, BSPBio_002506, ACMC-209kzt, ...

Fiser, R. et al., Tang, H.B. et al., Tsuzuki, K. et al., Ali, M.K. et al., Morales, S. et al., et al.

Baker, Akama, Zhang, Sauro, Pandit, Singh, Kully, Khan, Plattner, Benkovic, Lee, Maples,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC17107

The effects of a number of synthetic antibacterial agents of the borinic acid and diazaborine types on the growth of enteric bacteria were examined [1].

High impact information on NSC17107

The CyaA-mediated [Ca(2+)](i) increase in CD11b(+) J774A.1 monocytes was inhibited by extracellular La(3+) ions but not by nifedipine, SK&F 96365, flunarizine, 2-aminoethyl diphenylborinate, or thapsigargin, suggesting that influx of Ca(2+) into cells was not because of receptor signaling or opening of conventional calcium channels by cAMP [2].
Accumulation of calcyon in the plasma membrane correlated well with increased intracellular calcium levels as thapsigargin mimicked, and 2-aminoethoxydiphenylborane abrogated, the effects of priming [3].
Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane [4].
Interestingly, the inositol 1,4,5-triphosphate (IP3)-induced calcium release blocker [2-aminoethyl diphenylborinate (2-APB)] not only inhibited the potassium-evoked SP release, but also completely abolished the enhancement of capsaicin-induced SP release by bradykinin from cultured DRG neurons [5].
Exposure of isolated myocytes to 10 nM CCK caused a transient elevation in [Ca(2+)](i) that persisted in Ca(2+)-free medium and was inhibited by 2-aminoethoxydiphenylborane (2-APB) [6].

Associations of NSC17107 with other chemical compounds

A series of borinic acid picolinate esters were synthesized and screened for their minimum inhibitory concentration (MIC) against Gram-positive and -negative bacteria [7].
Menthol-induced increases of mEPSC frequency were blocked by 2-aminoethoxydiphenylborane (2-APB) but not affected by the phospholipase C inhibitor U73122 [GenBank] or by the cADP receptor inhibitor 8-bromo-cADPR (8Br-cADPR) [8].

References

Boron-containing antibacterial agents: effects on growth and morphology of bacteria under various culture conditions. Bailey, P.J., Cousins, G., Snow, G.A., White, A.J. Antimicrob. Agents Chemother. (1980) [Pubmed]
Third Activity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin: MEMBRANE TRANSLOCATION OF AC DOMAIN POLYPEPTIDE PROMOTES CALCIUM INFLUX INTO CD11b+ MONOCYTES INDEPENDENTLY OF THE CATALYTIC AND HEMOLYTIC ACTIVITIES. Fiser, R., Masín, J., Basler, M., Krusek, J., Spuláková, V., Konopásek, I., Sebo, P. J. Biol. Chem. (2007) [Pubmed]
Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. Ali, M.K., Bergson, C. J. Biol. Chem. (2003) [Pubmed]
Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Lievremont, J.P., Bird, G.S., Putney, J.W. Mol. Pharmacol. (2005) [Pubmed]
Substance P release evoked by capsaicin or potassium from rat cultured dorsal root ganglion neurons is conversely modulated with bradykinin. Tang, H.B., Inoue, A., Iwasa, M., Hide, I., Nakata, Y. J. Neurochem. (2006) [Pubmed]
Characterization of intracellular Ca(2+) stores in gallbladder smooth muscle. Morales, S., Camello, P.J., Mawe, G.M., Pozo, M.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases. Baker, S.J., Akama, T., Zhang, Y.K., Sauro, V., Pandit, C., Singh, R., Kully, M., Khan, J., Plattner, J.J., Benkovic, S.J., Lee, V., Maples, K.R. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
Menthol-induced Ca2+ release from presynaptic Ca2+ stores potentiates sensory synaptic transmission. Tsuzuki, K., Xing, H., Ling, J., Gu, J.G. J. Neurosci. (2004) [Pubmed]

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