The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

lanthanum(3+)     lanthanum(+3) cation

Synonyms: CHEBI:49701, AC1L2XOQ, AR-1J2992, La(3+), A810579, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIDS-072197

  • This influx was sensitive to blockers of TRP-like nonspecific Ca(2+) channels, including Ruthenium Red, La(3+), and Gd(3+) ions which also prevented the Fe(2+) ion-induced toxicity and oxidative stress as revealed by protein carbonylation status [1].
  • Examples are shown for the 185-residue N-terminal domain of the subunit epsilon from E. coli DNA polymerase III in complex with the subunit theta and La(3+) in its diamagnetic and Dy(3+), Tb(3+), and Er(3+) in its paramagnetic form [2].
  • A strain of polyphosphate-synthesizing, phosphate-releasing Acinetobacter johnsonii was isolated from a wastewater treatment plant operating enhanced biological phosphate removal (EBPR) and was used to remove La(3+) from solution via precipitation of cell-bound LaPO(4) [3].

High impact information on AIDS-072197


Biological context of AIDS-072197

  • In a 12-residue sequence taken from an EF-hand protein, the four C-terminal peptide units become helical when the peptide binds La(3+), and somewhat longer helices may be made by adding alanine residues at the C terminus [7].
  • The effect on exocytosis of La(3+), a known inhibitor of plasma membrane Ca(2+)-ATPases and Na(+)/Ca(2+) exchangers, was studied using cultured bovine adrenal chromaffin cells [8].
  • La(3+) showed a slightly higher affinity to the binding sites on the N-terminal domain of CaM than that to the C-terminal [9].
  • Both peptides required extracellular Ca(2+) to induce muscle contraction, and a blockage of sarcolemmal Ca(2+) channels by Mn(2+) or La(3+) inhibited myotropic effects [10].
  • The effects of these ions are very unlikely to be due to a surface charge effect because the addition of La(3+) (200 microm) completely reverses the shift in a hyperpolarizing direction when the extracellular Ca(2+) concentration was reduced from 10 to 1 mm and additionally shifts the kinetics further still in a depolarizing direction [11].

Anatomical context of AIDS-072197

  • The CyaA-mediated [Ca(2+)](i) increase in CD11b(+) J774A.1 monocytes was inhibited by extracellular La(3+) ions but not by nifedipine, SK&F 96365, flunarizine, 2-aminoethyl diphenylborinate, or thapsigargin, suggesting that influx of Ca(2+) into cells was not because of receptor signaling or opening of conventional calcium channels by cAMP [12].
  • Pretreatment of OECs with La(3+) reduced neurite regrowth in cocultures in a concentration-dependent manner over the range that blocked the non-voltage-gated calcium flux through a putative TRP-like channel, which, we propose, is activated in OEC-mediated axonal regeneration [13].
  • La(3+) inhibited (45)Ca(2+) efflux from preloaded chromaffin cells in the presence or absence of Na(+) [8].
  • In SDS/PAGE, it appears as a single protein band around Mr140 000 that can be phosphorylated by [gamma-(32)P]ATP in the presence of La(3+) and recognized by specific antibodies against the plasma membrane Ca(2+)-ATPase from pig antral smooth muscle [14].
  • These results suggest that VDAC, located in the mitochondrial outer membrane, controls Ca(2+) transport into and from the mitochondria, and that the inhibition of Ca(2+) uptake by RuR and La(3+) may result from their interaction with VDAC Ca(2+)-binding sites [15].

Associations of AIDS-072197 with other chemical compounds


Gene context of AIDS-072197

  • Using the specific TRP channel blocker La(3+) we demonstrated that both TRP and TRPL channel functions were unaffected [19].
  • The expression of the ccd-1 mRNA was induced by treatment with A23187, and the induction was suppressed by La(3+) or 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) [20].
  • This effect was prevented completely by inhibition of the plasma membrane Ca(2+)-ATPase (PMCA) with La(3+) [21].
  • At this stage, the cadherin 23 ectodomain epitope remains on the hair bundle following BAPTA or La(3+) treatment, but is lost following exposure to the protease subtilisin [22].
  • VDAC contains Ca(2+)-binding sites that bind Ruthenium Red (RuR), La(3+) and that RuR completely closed VDACs in single or multichannel experiments [15].

Analytical, diagnostic and therapeutic context of AIDS-072197

  • The heat of La(3+) interaction with the peptides at different temperatures is measured by isothermal titration calorimetry [23].
  • Using the whole cell patch clamp technique, we found that metabolic inhibitors activated a non-selective current permeant to both small and large cations, and blocked by La(3+), similar to the properties of connexin 43 when overexpressed in human embryonic kidney (HEK) cells [24].
  • In this report, we have investigated effects of La(3+) and Gd(3+) on the shape of giant unilamellar vesicle (GUV) of dioleoylphosphatidylcholine (DOPC-GUV) and GUV of DOPC/cholesterol by the phase-contrast microscopy [25].


  1. alpha-Tocopherol-mediated long-lasting protection against oxidative damage involves an attenuation of calcium entry through TRP-like channels in cultured hippocampal neurons. Crouzin, N., de Jesus Ferreira, M.C., Cohen-Solal, C., Aimar, R.F., Vignes, M., Guiramand, J. Free Radic. Biol. Med. (2007) [Pubmed]
  2. Efficient chi-tensor determination and NH assignment of paramagnetic proteins. Schmitz, C., John, M., Park, A.Y., Dixon, N.E., Otting, G., Pintacuda, G., Huber, T. J. Biomol. NMR (2006) [Pubmed]
  3. Phosphate uptake and release by Acinetobacter johnsonii in continuous culture and coupling of phosphate release to heavy metal accumulation. Boswell, C.D., Dick, R.E., Eccles, H., Macaskie, L.E. J. Ind. Microbiol. Biotechnol. (2001) [Pubmed]
  4. Ca2+ influx through distinct routes controls exocytosis and endocytosis at drosophila presynaptic terminals. Kuromi, H., Honda, A., Kidokoro, Y. Neuron (2004) [Pubmed]
  5. Internal aluminum block of plant inward K(+) channels. Liu, K., Luan, S. Plant Cell (2001) [Pubmed]
  6. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Contreras, J.E., Sánchez, H.A., Eugenin, E.A., Speidel, D., Theis, M., Willecke, K., Bukauskas, F.F., Bennett, M.V., Sáez, J.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Circular dichroism spectra of short, fixed-nucleus alanine helices. Chin, D.H., Woody, R.W., Rohl, C.A., Baldwin, R.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Mobilizing store Ca(2+) in the presence of La(3+) evokes exocytosis in bovine chromaffin cells. Marley, P.D., Bales, P.J., Zerbes, M., Powis, D.A., O'Farrell, M. J. Neurochem. (2000) [Pubmed]
  9. Binding of La3+ to calmodulin and its effects on the interaction between calmodulin and calmodulin binding peptide, polistes mastoparan. Hu, J., Jia, X., Li, Q., Yang, X., Wang, K. Biochemistry (2004) [Pubmed]
  10. Peptide-induced Ca(2+) movements in a tonic insect muscle: effects of proctolin and periviscerokinin-2. Wegener, C., Nässel, D.R. J. Neurophysiol. (2000) [Pubmed]
  11. Effect of calcium and calcium channel blockers on transient outward current of F76 and D1 neuronal soma membranes in the subesophageal ganglia of Helix aspersa. Bal, R., Janahmadi, M., Green, G.G., Sanders, D.J. J. Membr. Biol. (2000) [Pubmed]
  12. Third Activity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin: MEMBRANE TRANSLOCATION OF AC DOMAIN POLYPEPTIDE PROMOTES CALCIUM INFLUX INTO CD11b+ MONOCYTES INDEPENDENTLY OF THE CATALYTIC AND HEMOLYTIC ACTIVITIES. Fiser, R., Masín, J., Basler, M., Krusek, J., Spuláková, V., Konopásek, I., Sebo, P. J. Biol. Chem. (2007) [Pubmed]
  13. Intracellular calcium handling in rat olfactory ensheathing cells and its role in axonal regeneration. Hayat, S., Wigley, C.B., Robbins, J. Mol. Cell. Neurosci. (2003) [Pubmed]
  14. Purification of the synaptosomal plasma membrane (Ca(2+) + Mg(2+))-ATPase from pig brain. Salvador, J.M., Mata, A.M. Biochem. J. (1996) [Pubmed]
  15. Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function. Gincel, D., Zaid, H., Shoshan-Barmatz, V. Biochem. J. (2001) [Pubmed]
  16. Ca(2+) entry activated by S-nitrosylation. Relationship to store-operated ca(2+) entry. Ma, H.T., Favre, C.J., Patterson, R.L., Stone, M.R., Gill, D.L. J. Biol. Chem. (1999) [Pubmed]
  17. Catalysis of the methanolysis of activated amides by divalent and trivalent metal ions. The effect of Zn(2+), Co(2+), and La(3+) on the methanolysis of acetylimidazole and its (NH(3))(5)Co(III) complex. Neverov, A.A., Montoya-Pelaez, P.J., Brown, R.S. J. Am. Chem. Soc. (2001) [Pubmed]
  18. A mass spectrometric study of metal binding to osteocalcin. Nousiainen, M., Derrick, P.J., Kaartinen, M.T., Mäenpää, P.H., Rouvinen, J., Vainiotalo, P. Chem. Biol. (2002) [Pubmed]
  19. Normal phototransduction in Drosophila photoreceptors lacking an InsP(3) receptor gene. Raghu, P., Colley, N.J., Webel, R., James, T., Hasan, G., Danin, M., Selinger, Z., Hardie, R.C. Mol. Cell. Neurosci. (2000) [Pubmed]
  20. A rapid induction by elicitors of the mRNA encoding CCD-1, a 14kDa Ca2+ -binding protein in wheat cultured cells. Takezawa, D. Plant Mol. Biol. (2000) [Pubmed]
  21. Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. Bruce, J.I., Yule, D.I., Shuttleworth, T.J. J. Biol. Chem. (2002) [Pubmed]
  22. Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells. Michel, V., Goodyear, R.J., Weil, D., Marcotti, W., Perfettini, I., Wolfrum, U., Kros, C.J., Richardson, G.P., Petit, C. Dev. Biol. (2005) [Pubmed]
  23. The enthalpy of the alanine peptide helix measured by isothermal titration calorimetry using metal-binding to induce helix formation. Lopez, M.M., Chin, D.H., Baldwin, R.L., Makhatadze, G.I. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  24. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. Kondo, R.P., Wang, S.Y., John, S.A., Weiss, J.N., Goldhaber, J.I. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  25. La(3+) and Gd(3+) induce shape change of giant unilamellar vesicles of phosphatidylcholine. Tanaka, T., Tamba, Y., Masum, S.M., Yamashita, Y., Yamazaki, M. Biochim. Biophys. Acta (2002) [Pubmed]
WikiGenes - Universities