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Chemical Compound Review:

sodium octanoate sodium octanoate

Synonyms:

Amalaradjou, M.A. et al., Igawa, T. et al., Sabín, J. et al., Grekin, R.J. et al., Kajii, H. et al., et al.

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Disease relevance of octanoic acid

In this study, the efficacy of sodium caprylate for killing E. coli O157:H7 in cattle drinking water was investigated [1].

High impact information on octanoic acid

In nine conscious, instrumented rats, we studied the effects of 1-hour infusions of sodium oleate solution into the portal and femoral veins and infusions of sodium caprylate solution into the portal vein on 3 separate days [2].
It has been proposed that the agglutinin reacts with albumin that has been conformationally altered by sodium caprylate and that the immune complex is passively adsorbed onto red blood cells [3].
Three cases are presented in which the presence of sodium caprylate dependent albumin auto-agglutinins in the patients' sera resulted in erroneous Rh-hr phenotyping of their erythrocytes [4].
FITC-TP 5 can also be absorbed to such an extent ranging from 15 to 28% after intranasal administration of FITC-TP 5 alone, FITC-TP 5 with sodium caprylate, or with bacitracin, respectively [5].
Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate [6].

Chemical compound and disease context of octanoic acid

These results indicate that sodium caprylate is effective in killing E. coli O157:H7 in cattle drinking water, but detailed cattle palatability studies of water containing caprylate are necessary [1].

Biological context of octanoic acid

Determination of sodium caprylate in plasma volume expanders by gas chromatography [7].

Anatomical context of octanoic acid

The medium-chain fatty acid sodium caprylate released 6-carboxyfluorescein (CF), a model compound of water-soluble drugs, from the rat small intestinal brush border membrane (BBM) vesicles and liposomes containing CF [8].

Associations of octanoic acid with other chemical compounds

Complexation between human serum albumin (HSA) and two different surfactants, one fully fluorinated (sodium perfluorooctanoate, SPFO) and one fully hydrogenated (sodium caprylate, SO), was studied using zeta-potential measurements and difference spectroscopy [9].
The utility of the absorption promoters, sodium glycocholate (GC-Na), ethylenediamine dihydrochloride (EDTA-2Na), sodium caprylate (Cap-Na) and sodium salicylate (Sal-Na), in the intranasal administration of human fibroblast interferon-beta (HuIFN-beta) in rabbits was investigated [10].
It was found that N-acetyltryptophan and sodium caprylate displace bilirubin from its complex with human serum albumin in vitro [11].

References

Inactivation of escherichia coli O157:H7 in cattle drinking water by sodium caprylate. Amalaradjou, M.A., Annamalai, T., Marek, P., Rezamand, P., Schreiber, D., Hoagland, T., Venkitanarayanan, K. J. Food Prot. (2006) [Pubmed]
Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. Grekin, R.J., Vollmer, A.P., Sider, R.S. Hypertension (1995) [Pubmed]
Serologic activity of fatty acid dependent antibodies in albumin-free systems. Beck, M.L., Edwards, R.L., Pierce, S.R., Hicklin, B.L., Bayer, W.L. Transfusion (1976) [Pubmed]
Another potential source of error in Rh-hr typing. Reid, M.E., Ellisor, S.S., Frank, B.A. Transfusion (1975) [Pubmed]
Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague-Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers. Wang, J., Lu, W.L., Liang, G.W., Wu, K.C., Zhang, C.G., Zhang, X., Wang, J.C., Zhang, H., Wang, X.Q., Zhang, Q. Peptides (2006) [Pubmed]
Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate. Sawada, T., Ogawa, T., Tomita, M., Hayashi, M., Awazu, S. Pharm. Res. (1991) [Pubmed]
Determination of sodium caprylate in plasma volume expanders by gas chromatography. Lee, Y.C., Johnson, J.H. J. Chromatogr. (1986) [Pubmed]
Fluorescence study of the membrane-perturbing action of sodium caprylate as related to promotion of drug absorption. Kajii, H., Horie, T., Hayashi, M., Awazu, S. Journal of pharmaceutical sciences. (1988) [Pubmed]
Effects of fluorinated and hydrogenated surfactants on human serum albumin at different pHs. Sabín, J., Prieto, G., González-Pérez, A., Ruso, J.M., Sarmiento, F. Biomacromolecules (2006) [Pubmed]
Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits. Igawa, T., Maitani, Y., Machida, Y., Nagai, T. Chem. Pharm. Bull. (1989) [Pubmed]
Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin. Brodersen, R., Hansen, P. Acta paediatrica Scandinavica. (1977) [Pubmed]

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