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Chemical Compound Review

ECyd     4-amino-1-[(2R,3S,4S,5R)-4- ethynyl-3,4...

Synonyms: ETHYNYCYTIDINE, TAS-106, CHEMBL573352, NSC722662, PB24694, ...
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Disease relevance of TAS-106


High impact information on TAS-106


Biological context of TAS-106


Anatomical context of TAS-106

  • Measurement of UCK activity in these cell lines revealed that it was well correlated with the cells' sensitivity to TAS-106 [5].

Gene context of TAS-106


Analytical, diagnostic and therapeutic context of TAS-106

  • The antitumor ribonucleoside analogues 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) and 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)uracil (EUrd), first synthesized in 1995, have strong antitumor activity against human cancer xenografts without severe side effects [7].
  • During the development of the liquid chromatography with electrospray ionization-tandem mass spectrometry for the quantitative determination of 3'-C-ethynylcytidine (I) in rat plasma, ion suppression caused by the matrix components was observed for I and its structural analogue, 3'-C-ethylcytidine (II) as the internal standard [8].


  1. Cellular and biochemical mechanisms of the resistance of human cancer cells to a new anticancer ribo-nucleoside, TAS-106. Shimamoto, Y., Kazuno, H., Murakami, Y., Azuma, A., Koizumi, K., Matsuda, A., Sasaki, T., Fukushima, M. Jpn. J. Cancer Res. (2002) [Pubmed]
  2. Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine. Shimamoto, Y., Fujioka, A., Kazuno, H., Murakami, Y., Ohshimo, H., Kato, T., Matsuda, A., Sasaki, T., Fukushima, M. Jpn. J. Cancer Res. (2001) [Pubmed]
  3. Possible antitumor activity of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line. Kazuno, H., Sakamoto, K., Fujioka, A., Fukushima, M., Matsuda, A., Sasaki, T. Cancer Sci. (2005) [Pubmed]
  4. X irradiation induces the proapoptotic state independent of the loss of clonogenic ability in Chinese hamster V79 cells. Iizuka, D., Inanami, O., Matsuda, A., Kashiwakura, I., Asanuma, T., Kuwabara, M. Radiat. Res. (2005) [Pubmed]
  5. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Shimamoto, Y., Koizumi, K., Okabe, H., Kazuno, H., Murakami, Y., Nakagawa, F., Matsuda, A., Sasaki, T., Fukushima, M. Jpn. J. Cancer Res. (2002) [Pubmed]
  6. A novel anticancer ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells. Inanami, O., Iizuka, D., Iwahara, A., Yamamori, T., Kon, Y., Asanuma, T., Matsuda, A., Kashiwakura, I., Kitazato, K., Kuwabara, M. Radiat. Res. (2004) [Pubmed]
  7. Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)uracil. Takatori, S., Kanda, H., Takenaka, K., Wataya, Y., Matsuda, A., Fukushima, M., Shimamoto, Y., Tanaka, M., Sasaki, T. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  8. Improvement in precision of the liquid chromatographic-electrospray ionization tandem mass spectrometric analysis of 3'-C-ethynylcytidine in rat plasma. Kitamura, R., Matsuoka, K., Matsushima, E., Kawaguchi, Y. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
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