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Gene Review

UCK1  -  uridine-cytidine kinase 1

Homo sapiens

Synonyms: Cytidine monophosphokinase 1, FLJ12255, UCK 1, URK1, Uridine monophosphokinase 1, ...
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Disease relevance of UCK1


High impact information on UCK1


Biological context of UCK1


Anatomical context of UCK1

  • Measurement of UCK activity in these cell lines revealed that it was well correlated with the cells' sensitivity to TAS-106 [11].
  • The activity of Urd-Cyd kinase was increased approximately 2.3-fold, and that of OMP decarboxylase by about 91%, while that of FUPRTase was increased by only 27%, as compared to that of normal human colonic mucosa [3].

Associations of UCK1 with chemical compounds


Other interactions of UCK1


Analytical, diagnostic and therapeutic context of UCK1

  • Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer [1].


  1. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Van Rompay, A.R., Norda, A., Lindén, K., Johansson, M., Karlsson, A. Mol. Pharmacol. (2001) [Pubmed]
  2. Some properties of uridine-cytidine kinase from a human malignant lymphoma. Ahmed, N.K., Welch, A.D. Cancer Res. (1979) [Pubmed]
  3. Enzymes of salvage and de novo pathways of synthesis of pyrimidine nucleotides in human colorectal adenocarcinomas. Ahmed, N.K., Haggitt, R.C., Welch, A.D. Biochem. Pharmacol. (1982) [Pubmed]
  4. Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes. Coleman, C.N., Stoller, R.G., Drake, J.C., Chabner, B.A. Blood (1975) [Pubmed]
  5. Resistance to cyclopentenylcytosine in murine leukemia L1210 cells. Zhang, H., Cooney, D.A., Zhang, M.H., Ahluwalia, G., Ford, H., Johns, D.G. Cancer Res. (1993) [Pubmed]
  6. Effect of uridine on response of 5-azacytidine-resistant human leukemic cells to inhibitors of de novo pyrimidine synthesis. Grant, S., Bhalla, K., Gleyzer, M. Cancer Res. (1984) [Pubmed]
  7. Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes. Wu, J.Z., Larson, G., Walker, H., Shim, J.H., Hong, Z. Antimicrob. Agents Chemother. (2005) [Pubmed]
  8. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. Suzuki, N.N., Koizumi, K., Fukushima, M., Matsuda, A., Inagaki, F. Structure (Camb.) (2004) [Pubmed]
  9. Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd). Hrdlicka, P.J., Jepsen, J.S., Nielsen, C., Wengel, J. Bioorg. Med. Chem. (2005) [Pubmed]
  10. Target genes of the developmental regulator PRIB of the mushroom Lentinula edodes. Miyazaki, Y., Sakuragi, Y., Yamazaki, T., Shishido, K. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  11. Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Shimamoto, Y., Koizumi, K., Okabe, H., Kazuno, H., Murakami, Y., Nakagawa, F., Matsuda, A., Sasaki, T., Fukushima, M. Jpn. J. Cancer Res. (2002) [Pubmed]
  12. Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2. Suzuki, N.N., Koizumi, K., Fukushima, M., Matsuda, A., Inagaki, F. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
  13. Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells. Dahlig-Harley, E., Paterson, A.R., Robins, M.J., Cass, C.E. Cancer Res. (1984) [Pubmed]
  14. Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts. Grant, S., Cadman, E. Cancer Res. (1980) [Pubmed]
  15. Mechanism of Activation of {beta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase. Murakami, E., Bao, H., Ramesh, M., McBrayer, T.R., Whitaker, T., Micolochick Steuer, H.M., Schinazi, R.F., Stuyver, L.J., Obikhod, A., Otto, M.J., Furman, P.A. Antimicrob. Agents Chemother. (2007) [Pubmed]
  16. Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides. Roy, B., Verri, A., Lossani, A., Spadari, S., Focher, F., Aubertin, A.M., Gosselin, G., Mathé, C., Périgaud, C. Biochem. Pharmacol. (2004) [Pubmed]
  17. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides. Murata, D., Endo, Y., Obata, T., Sakamoto, K., Syouji, Y., Kadohira, M., Matsuda, A., Sasaki, T. Drug Metab. Dispos. (2004) [Pubmed]
  18. The roles of uridine-cytidine kinase and CTP synthetase in the synthesis of CTP in malignant human T-lymphocytic cells. van den Berg, A.A., van Lenthe, H., Busch, S., de Korte, D., van Kuilenburg, A.B., van Gennip, A.H. Leukemia (1994) [Pubmed]
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