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Chemical Compound Review

CCRIS 734     N-(4-phenylphenyl)ethanamide

Synonyms: CHEMBL300429, SureCN171741, NSC-3134, HSDB 5068, NSC-65931, ...
 
 
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Disease relevance of p-Phenylacetanilide

 

High impact information on p-Phenylacetanilide

 

Biological context of p-Phenylacetanilide

 

Anatomical context of p-Phenylacetanilide

 

Associations of p-Phenylacetanilide with other chemical compounds

 

Gene context of p-Phenylacetanilide

  • Postlabeling analyses following nuclease P1 digestion of the products obtained from the reaction of N-acetoxy-4-aminobiphenyl with deoxyguanosine-3'-monophosphate (dGp) demonstrated the presence of this minor adduct [12].
  • The antibody was produced by the immunization of two female New Zealand White rabbits and was found to be highly specific for 4-acetamidobiphenyl (4-AABP), the acetylated metabolite of 4-ABP [13].

References

  1. Mutagenicity of 4-aminobiphenyl and 4-acetylaminobiphenyl in Salmonella typhimurium strains expressing different levels of N-acetyltransferase. Dang, L.N., McQueen, C.A. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  2. The reduction of N-hydroxy-4-acetylaminobiphenyl by the intestinal microflora of the rat. Wheeler, L.A., Soderberg, F.B., Goldman, P. Cancer Res. (1975) [Pubmed]
  3. Monoclonal antibodies and rabbit antisera recognizing 4-aminobiphenyl--DNA adducts and application to immunoaffinity chromatography. Groopman, J.D., Skipper, P.L., Donahue, P.R., Trudel, L.J., Wildschutte, M., Kadlubar, F.F., Tannenbaum, S.R. Carcinogenesis (1992) [Pubmed]
  4. Acetyl transferase-mediated metabolic activation of N-hydroxy-4-aminobiphenyl by human uroepithelial cells. Frederickson, S.M., Hatcher, J.F., Reznikoff, C.A., Swaminathan, S. Carcinogenesis (1992) [Pubmed]
  5. N-arylhydroxamic acid N,O-acyltransferase. Positional requirements for the substrate hydroxyl group. Banks, R.B., Smith, T.J., Hanna, P.E. J. Med. Chem. (1983) [Pubmed]
  6. Reactive nitrogen oxygen species metabolize N-acetylbenzidine. Lakshmi, V.M., Hsu, F.F., Davis, B.B., Zenser, T.V. Chem. Res. Toxicol. (2001) [Pubmed]
  7. Comparison of acyltransferase-mediated mutagenicity and nucleic acid binding of N-acetoxy-4-acetylaminobiphenyl by hepatic and bladder microsomes from rats and dogs. Swaminathan, S., Hatcher, J.F. Environ. Mol. Mutagen. (1992) [Pubmed]
  8. In vitro deacetylation studies with isomeric acetamidobiphenyls using selective carboxylesterase inhibitors. Sertkaya, N.N., Gorrod, J.W. Anticancer Res. (1988) [Pubmed]
  9. Mutagenic activation of 4-aminobiphenyl and its N-hydroxy derivatives by microsomes from cultured human uroepithelial cells. Hatcher, J.F., Rao, K.P., Swaminathan, S. Mutagenesis (1993) [Pubmed]
  10. The in vitro/in vivo comparative metabolism of 4-aminobiphenyl using isolated hepatocytes. Jatoe, S.D., Gorrod, J.W. Arch. Toxicol. (1987) [Pubmed]
  11. Enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other species. Lower, G.M., Bryan, G.T. Journal of toxicology and environmental health. (1976) [Pubmed]
  12. Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl. Hatcher, J.F., Swaminathan, S. Environ. Mol. Mutagen. (2002) [Pubmed]
  13. Development of a radioimmunoassay procedure for 4-acetamidobiphenyl, a metabolite of the chemical carcinogen 4-aminobiphenyl, in urine. Johnson, H.J., Cernosek, S.F., Gutierrez-Cernosek, R.M., Brown, L.L. Journal of analytical toxicology. (1980) [Pubmed]
 
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