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Chemical Compound Review

NSC-338     N,N-dibenzylnitrous amide

Synonyms: NSC338, CHEMBL166071, CCRIS 2061, AG-F-83058, NSC 338, ...
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Disease relevance of NSC 338


High impact information on NSC 338


Chemical compound and disease context of NSC 338

  • The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535 [7].

Biological context of NSC 338


  1. Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo. Schmezer, P., Pool, B.L., Lefevre, P.A., Callander, R.D., Ratpan, F., Tinwell, H., Ashby, J. Environ. Mol. Mutagen. (1990) [Pubmed]
  2. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice. Jiao, J., Douglas, G.R., Gingerich, J.D., Soper, L.M. Carcinogenesis (1997) [Pubmed]
  3. Persistent proliferation of normal hepatocytes and promotion of preneoplastic development by N-nitrosodibenzylamine in rats. Blaszyk, H., Hartmann, A., Danz, M. J. Cancer Res. Clin. Oncol. (1993) [Pubmed]
  4. Statistical analysis of lacZ mutant frequency data from MutaMouse mutagenicity assays. Fung, K.Y., Douglas, G.R., Krewski, D. Mutagenesis (1998) [Pubmed]
  5. Dealkylation of N-nitrosodibenzylamine by metalloporphyrin/oxidant model systems for cytochrome P450. Okochi, E., Mochizuki, M. Chem. Pharm. Bull. (1995) [Pubmed]
  6. Kinetic study on the nitrosation of dibenzylamine in a model system. Ayala, N.L., Fiddler, W., Gates, R.A., Pensabene, J.W. Food Chem. Toxicol. (1994) [Pubmed]
  7. Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative. Jacobson, M.K., Barton, R.A., Yoder, S.S., Sigh, S., Lyle, R.E. Cancer Lett. (1979) [Pubmed]
  8. DNA damage induced by N-nitrosodibenzylamine and N-nitroso-alpha-acetoxybenzyl-benzylamine in mammalian cell systems and in vivo. Appel, K.E., Görsdorf, S., Menden, M., Lauterbach, M. Toxicol. Lett. (1990) [Pubmed]
  9. Metabolic denitrosation of N-nitrosamines: mechanism and biological consequences. Appel, K.E., Görsdorf, S., Scheper, T., Spiegelhalder, B., Wiessler, M., Schoepke, M., Engeholm, C., Kramer, R. IARC Sci. Publ. (1991) [Pubmed]
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