MeSH Review:
Dealkylation
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- Mechanisms of cytochrome P450 and peroxidase-catalyzed xenobiotic metabolism. Hollenberg, P.F. FASEB J. (1992)
- Comparison of the phenacetin and aminopyrine breath tests: effect of liver disease, inducers and cobaltous chloride. Schoeller, D.A., Kotake, A.N., Lambert, G.H., Krager, P.S., Baker, A.L. Hepatology (1985)
- Plant sterol biosynthesis. Identification and characterization of two distinct microsomal oxidative enzymatic systems involved in sterol C4-demethylation. Pascal, S., Taton, M., Rahier, A. J. Biol. Chem. (1993)
- Kinetics of the hydroperoxide-dependent dealkylation reactions catalyzed by rabbit liver microsomal cytochrome P-450. Koop, D.R., Hollenberg, P.F. J. Biol. Chem. (1980)
- Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine alpha-amidating enzyme. Bell, J., Ash, D.E., Snyder, L.M., Kulathila, R., Blackburn, N.J., Merkler, D.J. Biochemistry (1997)
- Identification of the metabolites of roxithromycin in humans. Zhong, D., Li, X., Wang, A., Xu, Y., Wu, S. Drug Metab. Dispos. (2000)
- Catalysis of the dealkylation/debenzylation of phenoxazone ethers by hemoglobin in the absence of peroxides: implications for investigations of embryonic biotransformation. Juchau, M.R., Chapman, D.E., Yang, H.Y., Lee, Q.P., Namkung, M.J., Hinds, T.R. Drug Metab. Dispos. (1996)
- Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. Daniels, D.S., Tainer, J.A. Mutat. Res. (2000)
- Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb. Ding, X.X., Coon, M.J. Mol. Pharmacol. (1990)
- Metabolism of N-alkyl compounds during the biosynthesis of prostaglandins. N-Dealkylation during prostaglandin biosynthesis. Sivarajah, K., Lasker, J.M., Eling, T.E., Abou-Donia, M.B. Mol. Pharmacol. (1982)
- Cryopreservation of rat and dog hepatocytes for studies of xenobiotic metabolism and activation. Powis, G., Santone, K.S., Melder, D.C., Thomas, L., Moore, D.J., Wilke, T.J. Drug Metab. Dispos. (1987)
- Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures. Wortelboer, H.M., van der Linden, E.C., de Kruif, C.A., Noordhoek, J., Blaauboer, B.J., van Bladeren, P.J., Falke, H.E. Food Chem. Toxicol. (1992)
- N-Demethylation reactions catalyzed by chloroperoxidase. Kedderis, G.L., Koop, D.R., Hollenberg, P.F. J. Biol. Chem. (1980)
- Hepatic microsomal dealkylations. Inhibition by a tyrosine-copper (II) complex provided with superoxide dismutase activity. Richter, C., Azzi, A., Weser, U., Wendel, A. J. Biol. Chem. (1977)
- Isolation of 2-fluorocitrate produced by in vivo dealkylation of 29-fluorostigmasterol in an insect. Prestwich, G.D., Yamaoka, R., Phirwa, S., DePalma, A. J. Biol. Chem. (1984)
- Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P-450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4. Afshar, M., Thormann, W. Electrophoresis (2006)
- High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans. Camus, A.M., Geneste, O., Honkakoski, P., Béréziat, J.C., Henderson, C.J., Wolf, C.R., Bartsch, H., Lang, M.A. Mol. Carcinog. (1993)
- Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. Tassaneeyakul, W., Birkett, D.J., Veronese, M.E., McManus, M.E., Tukey, R.H., Quattrochi, L.C., Gelboin, H.V., Miners, J.O. J. Pharmacol. Exp. Ther. (1993)
- Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli. McGinnity, D.F., Griffin, S.J., Moody, G.C., Voice, M., Hanlon, S., Friedberg, T., Riley, R.J. Drug Metab. Dispos. (1999)
- N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450. Hashizume, T., Mise, M., Terauchi, Y., O, L., Fujii, T., Miyazaki, H., Inaba, T. Drug Metab. Dispos. (1998)
- Minimal effect of acute experimental hepatitis induced by lipopolysaccharide/D-galactosamine on biotransformation in rats. Omar H el-D, n.u.l.l., Sanders, R.A., Watkins, J.B. Biochem. Pharmacol. (1996)
- pH-dependent geometric isomerization of roxithromycin in simulated gastrointestinal fluids and in rats. Zhang, S., Xing, J., Zhong, D. Journal of pharmaceutical sciences. (2004)