Disease relevance of Isomethepdrine chloride

• We report here on an autonomic dysreflexic syndrome following use of an isometheptene combination (Midrin), to treat migraine [1].
• Isometheptene compound in the treatment of vascular headache [2].
• Intracerebral hemorrhage in postpartum cerebral angiopathy associated with the use of isometheptene [3].

High impact information on Isomethepdrine chloride

• CONCLUSIONS: This case is additional evidence that sympathomimetic actions of some drugs, such as ergot derivatives and isometheptene, may lead to postpartum cerebral angiopathy [4].
• Sumatriptan, ergotamine, dihydroergotamine, isometheptene and clonidine failed to contract the meningeal artery, but 5-HT, noradrenaline and phenylephrine induced concentration-dependent contractions [5].
• One-minute intracarotid (intra-arterial; i.a.) infusions of isometheptene (10, 30, 100 and 300 microg/min) produced dose-dependent decreases in external carotid blood flow, without affecting blood pressure or heart rate [6].
• Isometheptene (0.03, 0.1, 0.3, 1 and 3 mg/kg, i.v.) produced dose-dependent increases in heart rate and diastolic blood pressure which were highly reproducible as they remained unaltered after saline [7].
• Autonomic dysreflexia due to medication: misadventure in the use of an isometheptene combination to treat migraine [1].

Anatomical context of Isomethepdrine chloride

• Inhibition of pancreatic exocrine secretion and bile entry into the duodenum by isometheptene, a sympathomimetic agent [8].

Gene context of Isomethepdrine chloride

• We have studied the effect of isometheptene, an indirectly acting sympathomimetic with analgesic and antispastic properties, on secretin-cholecystokinin-stimulated pancreatic and biliary outputs [8].

Analytical, diagnostic and therapeutic context of Isomethepdrine chloride

• Effect of isometheptene on the distribution and shunting of 15 microM microspheres throughout the cephalic circulation of the cat [9].

References