Disease relevance of Phenylethylmalondiamide

• Phenylethylmalonamide in essential tremor. A double-blind controlled study [1].
• Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure [2].

High impact information on Phenylethylmalondiamide

• The half-life of PB is twice that of PRM and PEMA [3].
• Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration [4].
• We describe a procedure for determining 2-ethyl-2-phenylmalonamide (I) in serum of epilepsy patients dosed with primidone (II) for seizure control, by extracting the sample with chloroform under basic conditions, with use of an internal standard, 2-ethyl-2-(p-tolyl)malonamide, and without derivative formation [5].
• Effects of primidone, phenobarbital and phenylethylmalonamide in the stimulated frog neuromuscular junction [6].
• Primidone but not phenylethylmalonamide, a major metabolite, increases nerve-evoked transmitter release at the frog neuromuscular junction [7].

Chemical compound and disease context of Phenylethylmalondiamide

• A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor [1].

Biological context of Phenylethylmalondiamide

• In conclusion phenytoin initially induces the conversion of primidone to PEMA and phenobarbitone, although each to a different extent, but it appears to inhibit the hydroxylation of phenobarbitone [8].
• Single-dose kinetics of primidone in human subjects: effect of phenytoin on formation and elimination of active metabolites of primidone, phenobarbital and phenylethylmalonamide [9].

Anatomical context of Phenylethylmalondiamide

• Microassay for primidone and its metabolites phenylethylmalondiamide, phenobarbital and p-hydroxyphenobarbital in human serum, saliva, breast milk and tissues by gas chromatography--mass spectrometry using selected ion monitoring [10].

Associations of Phenylethylmalondiamide with other chemical compounds

• After the column was washed, PRM, PEMA, PB, and IS were eluted with methanol and injected into the HPLC system [11].

Gene context of Phenylethylmalondiamide

• Monitoring 2-ethyl-2-phenylmalonamide in serum by gas-liquid chromatography: application to retrospective study in epilepsy patients dosed with primidone [5].
• Primidone, phenylethylmalonamide and phenobarbital concentrations rose linearly and dose-dependently in both serum and CSF [12].

Analytical, diagnostic and therapeutic context of Phenylethylmalondiamide

• Determination of phenylethylmalonamide by electron-capture gas chromatography [13].
• The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose [14].

References