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Chemical Compound Review:

Mycospor 1-[phenyl-(4- phenylphenyl)methyl]imidazole

Synonyms: Azolmen, Bifokey, Bifomyk, Bifonazol, Moldina, ...

Shadomy, S. et al., Niwano, Y. et al., Barug, D. et al., Yamaguchi, H. et al., Barug, D. et al., et al.

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Disease relevance of D01775

Treatment of tinea palmaris with Mycospor [1].
1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole (bifonazole, Bay h 4502, Mycospor) showed in vitro significant inhibitory activity against Torulopsis glabrata, Candida albicans, Pityrosporum ovale, Corynebacterium acnes and Staphylococcus epidermidis [2].

High impact information on D01775

2. In vitro antifungal activity in stratum corneum-containing medium: Candida albicans TIMM 2640 was incubated for 10 days at 27 degrees C in a vitamin-supplemented yeast carbon base medium containing 5 mg/ml of human stratum corneum and different concentrations of lanoconazole or bifonazole (CAS 60628-96-8, reference agent) [3].
The morphological changes in the growing hyphae of Trichophyton mentagrophytes treated with a new azole antimycotic bifonazole (Mycospor) were studied by high-resolution scanning electron microscopy [4].
The in vitro activity of 1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole bifonazole, Bay h 4502, Mycospor) a new antifungal imidazole derivative, against a variety of medically important fungi were studied using an agar dilution procedure [5].
The antifungal activity of a new topical imidazole, bifonazole (BAY h 4502, Bayer AG Institute for Chemotherapy), was compared in vitro with that of clotrimazole (BAY b 5097, Schering Corporation) in tests with 67 pathogenic and commensal yeasts, 45 dermatophytes and 14 miscellaneous pathogenic fungi by an agar dilution method [6].

Chemical compound and disease context of D01775

Bifonazole 1% cream (Mycospor 1) was compared to its cream vehicle in the treatment of tinea versicolor, using a once-a-day application for 2 weeks [7].

Associations of D01775 with other chemical compounds

The new imadozolyl derivative 1-(p, alpha-diphenyl-benzyl)imidazole (bifonazole, Bay h 4502, Mycospor) shows in vitro the broad spectrum of activity characteristic of azole antimycotics [8].

Analytical, diagnostic and therapeutic context of D01775

1-[(4-Biphenylyl)-phenylmethyl]-1H-imidazole (bifonazole, Bay h 4502, Mycospor) induced profound ultrastructural alterations in Candida albicans and Torulopsis glabrata as observed by freeze fracture electron microscopy [9].

References

Treatment of tinea palmaris with Mycospor. Meisel, C. Dermatologica (1984) [Pubmed]
An evaluation of the antifungal effect of bifonazole on Torulopsis glabrata and Candida albicans under various in vitro test conditions. Barug, D., Bastiaanse, H.B. Arzneimittel-Forschung. (1983) [Pubmed]
Studies on the antifungal activity of the new imidazole antimycotic lanoconazole in infected sites. Distribution in the skin and in vitro activity in the presence of stratum corneum. Niwano, Y., Matsui, M., Tabuchi, T., Kanai, K., Hamaguchi, H., Miyazaki, T., Uchida, K., Yamaguchi, H. Arzneimittel-Forschung. (1997) [Pubmed]
The effect of bifonazole on the structure of Trichophyton mentagrophytes. Osumi, M., Yamada, N., Yamada, Y., Yamaguchi, H. Dermatologica (1984) [Pubmed]
In vitro studies of a new imidazole antimycotic, bifonazole, in comparison with clotrimazole and miconazole. Yamaguchi, H., Hiratani, T., Plempel, M. Arzneimittel-Forschung. (1983) [Pubmed]
A comparison of bifonazole (BAY H 4502) with clotrimazole in vitro. Shadomy, S., Dixon, D.M., May, R. Sabouraudia. (1982) [Pubmed]
Comparative efficacy and tolerance of 1% bifonazole cream and bifonazole cream vehicle in patients with tinea versicolor. Mora, R.G., Greer, D.L. Dermatologica (1984) [Pubmed]
Antimycotic efficacy of bifonazole in vitro and in vivo. Plempel, M., Regel, E., Büchel, K.H. Arzneimittel-Forschung. (1983) [Pubmed]
Microscopic studies of Candida albicans and Torulopsis glabrata after in vitro treatment with bifonazole. Freeze fracture electron microscopy. Barug, D., de Groot, C. Arzneimittel-Forschung. (1983) [Pubmed]

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