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Chemical Compound Review

AC1NURIX     1-[(S)-phenyl-(4- phenylphenyl)methyl]imida...

Synonyms: SureCN1551534, NCGC00018254-01, NCGC00018254-06, 1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE
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Disease relevance of bifonazole


Psychiatry related information on bifonazole

  • Compared with the majority of topical antifungal drugs, which need to be applied at least twice daily, bifonazole offers the convenience of once daily administration, which may improve patient compliance [2].

High impact information on bifonazole


Chemical compound and disease context of bifonazole


Biological context of bifonazole


Anatomical context of bifonazole


Associations of bifonazole with other chemical compounds


Gene context of bifonazole

  • Reliability and reproducibility of the method was checked by analyzing laboratory mixtures of bifonazole and preservatives (recovery 99.97-102.7%; RDS 0.48-1.46%) [25].
  • The additional fungicidal effects of bifonazole are considered to originate from a sequential action by inhibition of HMG-CoA-reductase and of cytochrome P450 [26].
  • By this, in contrast to clotrimazole, bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase [13].
  • The decrease of the cooperativity at the gel to liquid crystalline phase transition, as shown by ESR an DSC measurements, indicates that bifonazole imparts higher fluidity to the lipid matrix [27].
  • We therefore verified the clinical efficacy of 1% bifonazole cream on 15 subjects with SD of the face, 9 of whom were affected with lymphadenopathy syndrome/AIDS-related complex (LAS/ARC) [28].

Analytical, diagnostic and therapeutic context of bifonazole

  • Gas chromatographic-mass spectrometric determination of two new antimycotic agents, 1-[(5-chloro-2-benzofuranyl)(2-chlorophenyl)methyl]-1H-imidazole and 1-[(5-bromo-2-benzofuranyl)phenylmethyl]-1H-imidazole, in rabbit plasma following topical administration: a preliminary comparison with bifonazole [12].
  • Treatment with bifonazole shampoo for seborrhea and seborrheic dermatitis: a randomized, double-blind study [29].
  • No side-reactions were observed in any patient, and patch tests carried out in selected patients with known allergy and those with normal skin showed no evidence of any allergic or photosensitivity reaction to bifonazole [30].
  • The aim of this research was to develop and validate a sensitive, rapid, easy, and precise reversed-phase liquid chromatography (LC) method for stability studies of bifonazole (I) formulated with tinctures of calendula flower (II) [31].
  • Western blot analyses demonstrated that bifonazole also induced P4502B1/2B2, P4503A and P4501A1, but not P4502E1 [32].


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  16. Diverse mechanisms of calcium mobilization by peroxisome proliferators in rat hepatocytes. Shackleton, G.L., Gibson, G.G., Sharma, R.K., Howes, D., Orrenius, S., Kass, G.E. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
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  20. In-vitro antifungal activity of sertaconazole, bifonazole, ketoconazole, and miconazole against yeasts of the Candida genus. Carrilo-Muñoz, A.J., Tur, C., Torres, J. J. Antimicrob. Chemother. (1996) [Pubmed]
  21. Selective calmodulin antagonists fail to inhibit phorbol ester-induced superoxide anion release from human neutrophils: effects of antifungal azole derivatives. Hegemann, L., Webster, G.F., Wolff, K. Br. J. Dermatol. (1996) [Pubmed]
  22. Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Hernandez, C.E., Kumar, S., Liu, H., Halpert, J.R. Arch. Biochem. Biophys. (2006) [Pubmed]
  23. A novel method using micropig stratum corneum in vitro for the evaluation of anti-Trichophyton mentagrophytes activity. Nakashima, T., Nozawa, A., Majima, T. Microbiol. Immunol. (2002) [Pubmed]
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