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MeSH Review


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Disease relevance of Arthrodermataceae


High impact information on Arthrodermataceae

  • Dermatophytes are adapted to infect keratinized tissues by their ability to utilize keratin as a nutrient source [6].
  • There has only been one clinically confirmed case of terbinafine resistance in dermatophytes, where six sequential Trichophyton rubrum isolates from the same patient were found to be resistant to terbinafine and cross-resistant to other squalene epoxidase (SE) inhibitors [7].
  • This is the first confirmed report of terbinafine resistance in dermatophytes [8].
  • The antifungal activity of fluconazole against these dermatophytes was increased in the presence of Ub proteasome inhibitor [9].
  • MICs were determined by a broth microdilution method with morpholinepropanesulfonic acid-buffered RPMI 1640 medium for Candida species and with Sabouraud dextrose broth for dermatophytes and by an agar dilution method with medium C for Malassezia furfur [10].

Chemical compound and disease context of Arthrodermataceae


Biological context of Arthrodermataceae


Anatomical context of Arthrodermataceae


Associations of Arthrodermataceae with chemical compounds


Gene context of Arthrodermataceae

  • A broadly reactive, yet fungus-specific, primer cocktail comprises two previously published primers, TR1 and TR2, which specifically amplify dermatophytes, and two newly designed primers, CA1 and AF2, which specifically amplify Candida and Aspergillus respectively [29].
  • Albino guinea pigs with abraded skin were inoculated cutaneously with 27 strains of dermatophytes from animals and humans [30].
  • No differences in the ability to support growth were observed among Taplin Dermatophyte Test medium, Dermatophyte Test Medium (Schering Diagnostics, Port Reading, N.J.),Sabouraud medium plus cycloheximide and chloramphenicol, Youssef medium for dermatophytes product no [31].
  • It can be differentiated from M. canis by the smaller size of its macroconidia, its failure to perforate hair in vitro, its poor growth and sporulation on bromocresol purple casein dextrose agar, and its incompatibility with Nannizzia otae, the telemorph of M. canis [32].
  • Molecular taxonomy of dermatophytes and related fungi by chitin synthase 1 (CHS1) gene sequences [33].

Analytical, diagnostic and therapeutic context of Arthrodermataceae


  1. Antimycotic imidazoles. 2. Synthesis and antimycotic properties of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles. Heeres, J., Mostmans, J.H., Cutsem, J.V. J. Med. Chem. (1977) [Pubmed]
  2. Once-weekly fluconazole (150, 300, or 450 mg) in the treatment of distal subungual onychomycosis of the fingernail. Drake, L., Babel, D., Stewart, D.M., Rich, P., Ling, M.R., Breneman, D., Scher, R.K., Martin, A.G., Pariser, D.M., Pariser, R.J., Ellis, C.N., Kang, S., Katz, H.I., McDonald, C.J., Muglia, J., Savin, R.C., Webster, G., Elewski, B.E., Leyden, J.J., Bucko, A.D., Tschen, E.H., Hanifin, J.M., Morman, M.R., Shupack, J.L., Greer, D.L. J. Am. Acad. Dermatol. (1998) [Pubmed]
  3. An open study of tinea capitis in 50 children treated with a 2-week course of oral terbinafine. Krafchik, B., Pelletier, J. J. Am. Acad. Dermatol. (1999) [Pubmed]
  4. Efficacy and tolerability of topical terbinafine in the treatment of tinea cruris. Millikan, L.E. J. Am. Acad. Dermatol. (1990) [Pubmed]
  5. Dermatophytosis: association between ABO blood groups and reactivity to the trichophytin. Vilani-Moreno, F.R., Arruda, M.S., Claro, S.G., Marcos, E.V., Ura, S. Rev. Inst. Med. Trop. Sao Paulo (1999) [Pubmed]
  6. Markers for host-induced gene expression in Trichophyton dermatophytosis. Kaufman, G., Berdicevsky, I., Woodfolk, J.A., Horwitz, B.A. Infect. Immun. (2005) [Pubmed]
  7. Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine. Osborne, C.S., Leitner, I., Favre, B., Ryder, N.S. Antimicrob. Agents Chemother. (2005) [Pubmed]
  8. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Mukherjee, P.K., Leidich, S.D., Isham, N., Leitner, I., Ryder, N.S., Ghannoum, M.A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  9. Expression of ubiquitin gene in Microsporum canis and Trichophyton mentagrophytes cultured with fluconazole. Kano, R., Okabayashi, K., Nakamura, Y., Watanabe, S., Hasegawa, A. Antimicrob. Agents Chemother. (2001) [Pubmed]
  10. In vitro antifungal activity of KP-103, a novel triazole derivative, and its therapeutic efficacy against experimental plantar tinea pedis and cutaneous candidiasis in guinea pigs. Tatsumi, Y., Yokoo, M., Arika, T., Yamaguchi, H. Antimicrob. Agents Chemother. (2001) [Pubmed]
  11. Itraconazole therapy is effective for pedal onychomycosis caused by some nondermatophyte molds and in mixed infection with dermatophytes and molds: a multicenter study with 36 patients. De Doncker, P.R., Scher, R.K., Baran, R.L., Decroix, J., Degreef, H.J., Roseeuw, D.I., Havu, V., Rosen, T., Gupta, A.K., Piérard, G.E. J. Am. Acad. Dermatol. (1997) [Pubmed]
  12. Superficial mycoses and in vitro sensitivity of dermatophytes and Candida species to tolciclate and clotrimazole. Jacob, Z., Wahab, S., Ghosh, M., Srivastava, O.P. Indian J. Med. Res. (1981) [Pubmed]
  13. The dermatopharmacologic profile of ciclopirox 8% nail lacquer. Bohn, M., Kraemer, K. Journal of the American Podiatric Medical Association. (2000) [Pubmed]
  14. Tinea pedis in European marathon runners. Lacroix, C., Baspeyras, M., de La Salmonière, P., Benderdouche, M., Couprie, B., Accoceberry, I., Weill, F.X., Derouin, F., Feuilhade de Chauvin, M. Journal of the European Academy of Dermatology and Venereology : JEADV. (2002) [Pubmed]
  15. Molecular analysis of chitin synthase 1 (CHS1) gene sequences of Trichophyton mentagrophytes complex and T. rubrum. Kano, R., Nakamura, Y., Watari, T., Watanabe, S., Takahashi, H., Tsujimoto, H., Hasegawa, A. Curr. Microbiol. (1998) [Pubmed]
  16. Isolation and genotype analyses of ascospores produced between genetically different Arthroderma benhamiae strains. Kawasaki, M., Mochizuki, T., Ishizaki, H., Fujihiro, M. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology. (2002) [Pubmed]
  17. Contribution to our knowledge of Trichophyton megninii. Sequeira, H., Cabrita, J., De Vroey, C., Wuytack-Raes, C. J. Med. Vet. Mycol. (1991) [Pubmed]
  18. Epidemiology of dermatomycoses of humans in central Poland. Part IV. Onychomycosis due to dermatophytes. Lupa, S., Seneczko, F., Jeske, J., Głowacka, A., Ochecka-Szymańska, A. Mycoses (1999) [Pubmed]
  19. Once-weekly fluconazole (450 mg) for 4, 6, or 9 months of treatment for distal subungual onychomycosis of the toenail. Ling, M.R., Swinyer, L.J., Jarratt, M.T., Falo, L., Monroe, E.W., Tharp, M., Kalivas, J., Weinstein, G.D., Asarch, R.G., Drake, L., Martin, A.G., Leyden, J.J., Cook, J., Pariser, D.M., Pariser, R., Thiers, B.H., Lebwohl, M.G., Babel, D., Stewart, D.M., Eaglstein, W.H., Falanga, V., Katz, H.I., Bergfeld, W.F., Hanifin, J.M., Young, M.R. J. Am. Acad. Dermatol. (1998) [Pubmed]
  20. Levels of terbinafine in plasma, stratum corneum, dermis-epidermis (without stratum corneum), sebum, hair and nails during and after 250 mg terbinafine orally once daily for 7 and 14 days. Faergemann, J., Zehender, H., Millerioux, L. Clin. Exp. Dermatol. (1994) [Pubmed]
  21. Evaluation of ketoconazole. Sohn, C.A. Clinical pharmacy. (1982) [Pubmed]
  22. Carbohydrate composition of the isolated cell walls of dermatophytes. Noguchi, T., Banno, Y., Watanabe, T., Nozawa, Y., Ito, Y. Mycopathologia (1975) [Pubmed]
  23. Cell-mediated immunity in the immunopathogenesis of dermatophytosis. Jones, H.E. Acta dermato-venereologica. Supplementum. (1986) [Pubmed]
  24. In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum. Hata, K., Kimura, J., Miki, H., Toyosawa, T., Nakamura, T., Katsu, K. Antimicrob. Agents Chemother. (1996) [Pubmed]
  25. In vitro studies with R 51,211 (itraconazole). Espinel-Ingroff, A., Shadomy, S., Gebhart, R.J. Antimicrob. Agents Chemother. (1984) [Pubmed]
  26. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Sawyer, P.R., Brogden, R.N., Pinder, R.M., Speight, T.M., Avery, n.u.l.l. Drugs (1975) [Pubmed]
  27. Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Monk, J.P., Brogden, R.N. Drugs (1991) [Pubmed]
  28. Miconazole: a review of its antifungal activity and therapeutic efficacy. Sawyer, P.R., Brogden, R.N., Pinder, R.M., Speight, T.M., Avery, G.S. Drugs (1975) [Pubmed]
  29. Universal fungus-specific primer systems and group-specific hybridization oligonucleotides for 18S rDNA. Kappe, R., Fauser, C., Okeke, C.N., Maiwald, M. Mycoses (1996) [Pubmed]
  30. Experimental systemic dermatophytosis. Van Cutsem, J., Janssen, P.A. J. Invest. Dermatol. (1984) [Pubmed]
  31. Dermatophyte isolation media: quantitative appraisal using skin scales infected with Trichophyton mentagrophytes and Trichophyton rubrum. Sinski, J.T., Kelley, L.M., Flynt, P.M., Miegel, J. J. Clin. Microbiol. (1977) [Pubmed]
  32. Microsporum equinum in North America. Kane, J., Padhye, A.A., Ajello, L. J. Clin. Microbiol. (1982) [Pubmed]
  33. Molecular taxonomy of dermatophytes and related fungi by chitin synthase 1 (CHS1) gene sequences. Hirai, A., Kano, R., Nakamura, Y., Watanabe, S., Hasegawa, A. Antonie Van Leeuwenhoek (2003) [Pubmed]
  34. Isolation of an intron-containing partial sequence of the gene encoding dermatophyte actin (ACT) and detection of a fragment of the transcript by reverse transcription-nested PCR as a means of assessing the viability of dermatophytes in skin scales. Okeke, C.N., Tsuboi, R., Kawai, M., Hiruma, M., Ogawa, H. J. Clin. Microbiol. (2001) [Pubmed]
  35. Dermatopharmacology of ciclopirox nail lacquer topical solution 8% in the treatment of onychomycosis. Bohn, M., Kraemer, K.T. J. Am. Acad. Dermatol. (2000) [Pubmed]
  36. Simultaneous demonstration of infecting fungi and DNA-synthesizing epithelial cells in the skin. Fujita, S., Tezuka, M., Kaise, A., Ito, M. Mycoses (1993) [Pubmed]
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