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Chemical Compound Review

BABIM     2-[(6-carbamimidoyl-1H- benzoimidazol-2...

Synonyms: CHEMBL99951, SureCN65730, SureCN871141, AG-J-83940, CHEBI:265384, ...
 
 
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Disease relevance of Bis(5-amidino-2-benzimidazolyl)methane

 

High impact information on Bis(5-amidino-2-benzimidazolyl)methane

 

Biological context of Bis(5-amidino-2-benzimidazolyl)methane

  • The strongest inhibitors of tryptase in this series are bis(5-amidino-2-benzimidazolyl)methane (BABIM) and (5-amidino-2-benzimidazolyl)-(5-(N,N'-dimethylamidino)-2- benzimidazolyl)methane, which exhibit K(i) values of 1.8 and 1.4 nM, respectively, in blocking the hydrolysis of tosyl-L-Gly-Pro-Lys-4-nitroanilide by human tryptase [6].

References

  1. Streptococcal cell wall-induced systemic disease. Beneficial effects of trans-bis(5-amidino-2-benzimidazolyl)ethene, a novel, macrophage-directed anti-inflammatory agent. Geratz, J.D., Tidwell, R.R., Lombardy, R.J., Schwab, J.H., Anderle, S.K., Pryzwansky, K.B. Am. J. Pathol. (1991) [Pubmed]
  2. Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM). Geratz, J.D., Tidwell, R.R., Schwab, J.H., Anderle, S.K., Pryzwansky, K.B. Am. J. Pathol. (1990) [Pubmed]
  3. Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane. Tidwell, R.R., Geratz, J.D., Clyde, W.A., Rosenthal, K.U., Dubovi, E.J. Antimicrob. Agents Chemother. (1984) [Pubmed]
  4. A novel mechanism for Clostridium botulinum neurotoxin inhibition. Eswaramoorthy, S., Kumaran, D., Swaminathan, S. Biochemistry (2002) [Pubmed]
  5. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Akers, I.A., Parsons, M., Hill, M.R., Hollenberg, M.D., Sanjar, S., Laurent, G.J., McAnulty, R.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  6. Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases. Caughey, G.H., Raymond, W.W., Bacci, E., Lombardy, R.J., Tidwell, R.R. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
 
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