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Chemical Compound Review

Isolyte     dipotassiumhydroxy-dioxido- oxo-phosphorane

Synonyms: HSDB 935, CCRIS 6544, AG-C-25514, CHEMBL1200459, ACMC-20al4r, ...
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Disease relevance of Isolyte


High impact information on Isolyte

  • Additionally, the Isolyte S group had a lower chloride concentration (mEq/L: normal values 95 to 110; normal saline 130 +/- 9 vs. Isolyte S 117 +/- 7 [p < .02]) and a lower potassium concentration (mEq/L: normal values 3.5 to 5.0; normal saline 4.4 +/- 0.5 vs. Isolyte S 3.7 +/- 0.3 [p < .01]) [2].
  • By the end of the study, the Isolyte S group had a normal pH and an increased bicarbonate concentration (mEq/L: normal values 24 to 32; normal saline 9.0 +/- 1.9 vs. Isolyte S 13.2 +/- 3.0 [p < .01]) and an increased magnesium concentration (mg/dL: normal values 1.6 to 2.4; normal saline 1.6 +/- 0.2 vs. Isolyte S 2.2 +/- 0.2 [p < .0001]) [2].
  • Clinical studies of bone density using CT commonly employ a dipotassium phosphate phantom to calibrate measurements of mineral density [3].
  • In 10 chronically catheterized fetal sheep averaging 130 +/- 1 (SE) days' gestation, a balanced, isotonic electrolyte solution (Isolyte S) was infused continuously for 5 days into a fetal vein at a rate of 0, 1, 2, 4, and 0 L/day, respectively [4].
  • The capability of the method was demonstrated on separation of cytochrome c and lysozyme using a PEG-aqueous dibasic potassium phosphate-aqueous two-phase solvent system [5].

Anatomical context of Isolyte


Associations of Isolyte with other chemical compounds


Gene context of Isolyte

  • The analytes were separated on a Brownlee Spheri-5 C18 column with a mobile phase of acetonitrile-20 mM dibasic potassium phosphate pH 3 buffer (40:60, v/v) [11].

Analytical, diagnostic and therapeutic context of Isolyte

  • OBJECTIVES: The purpose of this study is to compare normal saline with Isolyte S as the wash solutions during high-volume cell saver autologous blood transfusion [2].
  • The infarct + HUCBC group consisted of 38 rats that underwent LAD ligation and after 1 h were given 10(6) HUCBC in Isolyte directly into the infarct border [1].
  • The HPLC method is an isocratic method with a mobile phase of acetonitrile:methanol:10 mmol l-1 dipotassium hydrogen phosphate, pH 3.7 (30:2:100), at a flow rate of 1.5 ml min-1 [12].


  1. Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction. Henning, R.J., Abu-Ali, H., Balis, J.U., Morgan, M.B., Willing, A.E., Sanberg, P.R. Cell transplantation. (2004) [Pubmed]
  2. Isolyte S, a physiologic multielectrolyte solution, is preferable to normal saline to wash cell saver salvaged blood: conclusions from a prospective, randomized study in a canine model. Halpern, N.A., Alicea, M., Seabrook, B., Spungen, A., Greenstein, R. Crit. Care Med. (1997) [Pubmed]
  3. Technical note: CT determination of the mineral density of dry bone specimens using the dipotassium phosphate phantom. Chen, X., Lam, Y.M. Am. J. Phys. Anthropol. (1997) [Pubmed]
  4. Fetal blood volume, urine flow, swallowing, and amniotic fluid volume responses to long-term intravascular infusions of saline. Brace, R.A. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  5. Multi-stage mixer-settler planet centrifuge. Preliminary studies on partition of macromolecules with organic-aqueous and aqueous-aqueous two-phase solvent systems. Ito, Y., Zhang, T.Y. J. Chromatogr. (1988) [Pubmed]
  6. Prediction of vertebral body compressive fracture using quantitative computed tomography. McBroom, R.J., Hayes, W.C., Edwards, W.T., Goldberg, R.P., White, A.A. The Journal of bone and joint surgery. American volume. (1985) [Pubmed]
  7. Bacterial growth inhibition by amniotic fluid. IV. Studies on the nature of bacterial inhibition with the use of plate-count determinations. Schlievert, P., Larsen, B., Johnson, W., Galask, R.P. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  8. Integration of production and aqueous two-phase systems extraction of extracellular Fusarium solani pisi cutinase fusion proteins. Cunha, M.T., Costa, M.J., Calado, C.R., Fonseca, L.P., Aires-Barros, M.R., Cabral, J.M. J. Biotechnol. (2003) [Pubmed]
  9. Sensitive assay for the determination of cefazolin or ceftriaxone in plasma utilizing LC. Al-Rawithi, S., Hussein, R., Raines, D.A., AlShowaier, I., Kurdi, W. Journal of pharmaceutical and biomedical analysis. (2000) [Pubmed]
  10. Calcium and phosphate solubility curves for parenteral nutrient solutions containing aminoplasmal-paed, Aminovenos-N-pad or Moripron-F. Mo-Suwan, L., Apiromrak, B., Puetpaiboon, A. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1993) [Pubmed]
  11. Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma. Hutzler, J.M., Frye, R.F., Tracy, T.S. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  12. Analysis of clobazam and its active metabolite norclobazam in plasma and serum using HPLC/DAD. Akerman, K.K. Scand. J. Clin. Lab. Invest. (1996) [Pubmed]
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