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Chemical Compound Review

Calciofon     calcium (2R,3S,4R,5R)-2,3,4,5,6...

Synonyms: Calcicol, Calcipur, Dragocal, Calglucol, Calglucon, ...
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Disease relevance of D-gluconic acid


High impact information on D-gluconic acid


Chemical compound and disease context of D-gluconic acid


Biological context of D-gluconic acid


Anatomical context of D-gluconic acid


Associations of D-gluconic acid with other chemical compounds


Gene context of D-gluconic acid

  • In order to establish whether small Cai increments are also able to modify the basal secretion of arginine vasopressin (AVP), we infused calcium gluconate through an intravenous infusion pump in eight healthy male subjects (25-31 years old) [30].
  • Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output [31].
  • Intraperitoneal injection of calcium gluconate caused progressive increases in serum calcium over 120 minutes, with corresponding decreases in serum PTH levels [32].
  • The addition of 1% calcium gluconate to the drinking water significantly reduced STC mRNA levels in inner medullary CD cells of both males and females, but not those in the cortex and outer medulla [33].
  • Serum calcium was decreased by ip phosphorus and increased by calcium gluconate (ip or iv infusion) and demonstrated that a low serum calcium markedly increased PTH mRNA levels whereas a high serum calcium had no effect [34].

Analytical, diagnostic and therapeutic context of D-gluconic acid


  1. Secretin and calcium provocative tests in the Zollinger-Ellison syndrome. A prospective study. Frucht, H., Howard, J.M., Slaff, J.I., Wank, S.A., McCarthy, D.M., Maton, P.N., Vinayek, R., Gardner, J.D., Jensen, R.T. Ann. Intern. Med. (1989) [Pubmed]
  2. Effects of oral calcium gluconate on gastric acid secretion and serum gastrin concentration in man. Brodie, M.J., Ganguli, P.C., Fine, A., Thomson, T.J. Gut (1977) [Pubmed]
  3. Vitamin D metabolism during recovery from severe osteitis fibrosa cystica of primary hyperparathyroidism. Gonzalez-Villapando, C., Porath, A., Berelowitz, M., Marshall, L., Favus, M.J. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  4. Effects of disodium EDTA and calcium infusion on prolactin and thyrotropin responses to thyrotropin-releasing hormone in healthy man. Dudczak, R., Waldhäusl, W.K., Bratusch-Marrain, P. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  5. Lack of effect of calcium infusion on blood glucose and plasma insulin levels in patients with insulinoma. De Palo, C., Sicolo, N., Vettor, R., Federspil, G. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  6. Digoxin reduces beta-adrenergic contractile response in rabbit hearts. Ca(2+)-dependent inhibition of adenylyl cyclase activity via Na+/Ca2+ exchange. Nagai, K., Murakami, T., Iwase, T., Tomita, T., Sasayama, S. J. Clin. Invest. (1996) [Pubmed]
  7. Jejunal and ileal absorption in patients with chronic renal disease. Effect of 1alpha-hydroxycholecalciferol. Vergne-Marini, P., Parker, T.F., Pak, C.Y., Hull, A.R., DeLuca, H.F., Fordtran, J.S. J. Clin. Invest. (1976) [Pubmed]
  8. Acute intestinal injury induced by acetic acid and casein: prevention by intraluminal misoprostol. Miller, M.J., Zhang, X.J., Gu, X.A., Clark, D.A. Gastroenterology (1991) [Pubmed]
  9. Basal and calcium-stimulated gastroesophageal sphincter pressure in patients with Zollinger-Ellison syndrome. Snyder, N., Hughes, W. Gastroenterology (1977) [Pubmed]
  10. Intrarenal site of action of calcium on renin secretion in dogs. Watkins, B.E., Davis, J.O., Lohmeier, T.E., Freeman, R.H. Circ. Res. (1976) [Pubmed]
  11. Role of the loop segment in the urinary concentrating defect of hypercalcemia. Galla, J.H., Booker, B.B., Luke, R.G. Kidney Int. (1986) [Pubmed]
  12. Ionization and hemodynamic effects of calcium chloride and calcium gluconate in the absence of hepatic function. Martin, T.J., Kang, Y., Robertson, K.M., Virji, M.A., Marquez, J.M. Anesthesiology (1990) [Pubmed]
  13. Effect of nicardipine on the reversal of magnesium toxicity by calcium gluconate in nonpregnant rabbits. Moir, M., Holbrook, R.H. Obstetrics and gynecology. (1993) [Pubmed]
  14. Prevention of citrate reactions during therapeutic plasma exchange by constant infusion of calcium gluconate with the return fluid. Weinstein, R. Journal of clinical apheresis. (1996) [Pubmed]
  15. The use of calcium gluconate prior to verapamil in infants with paroxysmal supraventricular tachycardia. Roguin, N., Shapir, Y., Blazer, S., Zeltzer, M., Berant, M. Clinical cardiology. (1984) [Pubmed]
  16. Alpha-N-acetylmannosamine (ManNAc) synthesis via rhodium(II)-catalyzed oxidative cyclization of glucal 3-carbamates. Bodner, R., Marcellino, B.K., Severino, A., Smenton, A.L., Rojas, C.M. J. Org. Chem. (2005) [Pubmed]
  17. The cardiopulmonary effects of calcium infusion in infants with persistent pulmonary hypertension of the newborn. Bifano, E., Kavey, R.E., Pergolizzi, J., Slagle, T., Bergstrom, W. Pediatr. Res. (1989) [Pubmed]
  18. Drug interactions I: Folic acid and calcium gluconate. Scott, K.R., Bell, A.F., Telang, V.G. Journal of pharmaceutical sciences. (1980) [Pubmed]
  19. The synergistic effect of calcium and prostaglandin F2alpha in second trimester abortion. A pilot study. Weinstein, L., Droegemueller, W., Greer, B. Obstetrics and gynecology. (1976) [Pubmed]
  20. A single mechanism to explain the effect of calcium on renal function. Lahera, V., Ruilope, L.M., Romero, J.C. Am. J. Hypertens. (1991) [Pubmed]
  21. In vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate. Schaefer, S., Lange, R.A., Kulkarni, P.V., Katz, J., Parkey, R.W., Willerson, J.T., Peshock, R.M. J. Am. Coll. Cardiol. (1989) [Pubmed]
  22. Localization of insulinomas by selective intraarterial calcium injection. O'Shea, D., Rohrer-Theurs, A.W., Lynn, J.A., Jackson, J.E., Bloom, S.R. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  23. Insulinomas: localization with selective intraarterial injection of calcium. Doppman, J.L., Miller, D.L., Chang, R., Shawker, T.H., Gorden, P., Norton, J.A. Radiology. (1991) [Pubmed]
  24. Hazards of calcium gluconate therapy in the newborn infant: intra-arterial injection producing intestinal necrosis in rabbit ileum. Book, L.S., Herbst, J.J., Stewart, D. J. Pediatr. (1978) [Pubmed]
  25. Direct in vivo comparison of calcium-regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism. Ramirez, J.A., Goodman, W.G., Gornbein, J., Menezes, C., Moulton, L., Segre, G.V., Salusky, I.B. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  26. Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. Brent, G.A., LeBoff, M.S., Seely, E.W., Conlin, P.R., Brown, E.M. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  27. Reduction of adverse citrate reactions during autologous large-volume PBPC apheresis by continuous infusion of calcium-gluconate. Buchta, C., Macher, M., Bieglmayer, C., Höcker, P., Dettke, M. Transfusion (2003) [Pubmed]
  28. Brain calcification in severely stressed neonates receiving parenteral calcium. Changaris, D.G., Purohit, D.M., Balentine, J.D., Levkoff, A.H., Holden, A.E., Dean, D.L., Biggs, P.J. J. Pediatr. (1984) [Pubmed]
  29. Manganese-calcium interactions with contrast media for cardiac magnetic resonance imaging: a study of manganese chloride supplemented with calcium gluconate in isolated Guinea pig hearts. Bruvold, M., Nordhøy, W., Anthonsen, H.W., Brurok, H., Jynge, P. Investigative radiology. (2005) [Pubmed]
  30. Stimulation of arginine vasopressin secretion by a small increase in blood ionized calcium in normal men. Chiodera, P., Volpi, R., Capretti, L., Caffarri, G., Pilla, S., Coiro, V. Eur. J. Clin. Invest. (1997) [Pubmed]
  31. Interaction of calcium and magnesium on gastric acid secretion and serum gastrin concentration in man. Christiansen, J., Rehfeld, J.F., Stadil, F. Gastroenterology (1975) [Pubmed]
  32. A new method for in vivo analysis of parathyroid hormone-calcium set point in mice. Imanishi, Y., Hall, C., Sablosky, M., Brown, E.M., Arnold, A. J. Bone Miner. Res. (2002) [Pubmed]
  33. Post-natal ontogeny of stanniocalcin gene expression in rodent kidney and regulation by dietary calcium and phosphate. Deol, H., Stasko, S.E., De Niu, P., James, K.A., Wagner, G.F. Kidney Int. (2001) [Pubmed]
  34. Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-dihydroxyvitamin D. Naveh-Many, T., Friedlaender, M.M., Mayer, H., Silver, J. Endocrinology (1989) [Pubmed]
  35. Changes in serum calcium levels influence biliary calcium levels in humans. Gleeson, D., Murphy, G.M., Dowling, R.H. Gastroenterology (1994) [Pubmed]
  36. Correction of hypocalcaemic symptoms during plasma exchange. Buskard, N.A., Varghese, Z., Wills, M.R. Lancet (1976) [Pubmed]
  37. Effects of the experimental chemopreventative agent, glucarate, on intestinal carcinogenesis in rats. Dwivedi, C., Oredipe, O.A., Barth, R.F., Downie, A.A., Webb, T.E. Carcinogenesis (1989) [Pubmed]
  38. Brain fluid calcium concentration and response to acute hypercalcaemia during development in the rat. Jones, H.C., Keep, R.F. J. Physiol. (Lond.) (1988) [Pubmed]
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