Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

o,p-DDE 1-chloro-4-[2,2-dichloro-1- (2...

Synonyms: CHEMBL1391, AG-F-16316, O,P'-DDE, NSC-59908, AC1L6IFB, ...

Wu, Y. et al., Mössner, S. et al., Smeets, J.M. et al., Milston, R.H. et al.

Milston, Fitzpatrick, Vella, Clements, Gundersen, Feist, Crippen, Leong, Schreck,

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Disease relevance of C14133

Pertussis toxin treatment inhibited the [Ca2+]i increases induced by estradiol, p,p'-DDE, o,p-DDE and methoxychlor, but not by Kepone or progesterone, indicating that Kepone and progesterone may act through an insensitive G protein-coupled receptor [1].

High impact information on C14133

Short-term exposure of Chinook salmon (Oncoryhnchus tshawytscha) to o,p-DDE or DMSO during early life-history stages causes long-term humoral immunosuppression [2].
The synthetic estrogen DES had a relative estrogenic potency of 0.5, whereas dieldrin, beta-endosulfan, o,p-DDE, and toxaphene (technical mixture) did not induce vitellogenesis at concentrations up to 100 microM [3].
As xenobiotics were quantified the seven indicator congeners of the polychlorinated biphenyls (PCB 28, 52, 101, 118, 138, 153, and 180), three isomers of the hexachlorocyclohexanes (alpha-, beta- and gamma-HCH) as well as six components of the DDT-group (4,4'-DDT, 4,4'-DDD, 4,4'-DDE, 2,4'-DDT, 2,4'-DDD, and 2,4'-DDE) [4].
The isomer o,p-DDE at 3 nmol/ml increased [Ca2+]i in granulosa cells of 11/20 patients [1].

References

Rapid effects of pesticides on human granulosa-lutein cells. Wu, Y., Foster, W.G., Younglai, E.V. Reproduction (2006) [Pubmed]
Short-term exposure of Chinook salmon (Oncoryhnchus tshawytscha) to o,p-DDE or DMSO during early life-history stages causes long-term humoral immunosuppression. Milston, R.H., Fitzpatrick, M.S., Vella, A.T., Clements, S., Gundersen, D., Feist, G., Crippen, T.L., Leong, J., Schreck, C.B. Environ. Health Perspect. (2003) [Pubmed]
Estrogenic potencies of several environmental pollutants, as determined by vitellogenin induction in a carp hepatocyte assay. Smeets, J.M., van Holsteijn, I., Giesy, J.P., Seinen, W., van den Berg, M. Toxicol. Sci. (1999) [Pubmed]
Marine mammals as global pollution indicators for organochlorines. Mössner, S., Ballschmiter, K. Chemosphere (1997) [Pubmed]

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