Chemical Compound Review:
Metox 1-methoxy-4-[2,2,2-trichloro- 1-(4...
Synonyms:
Maralate, Marlate, Methoxo, Higalmetox, Methoxcide, ...
Welshons,
Nagel,
Thayer,
Judy,
Vom Saal,
Gaido,
Maness,
McDonnell,
Dehal,
Kupfer,
Safe,
You,
Casanova,
Bartolucci,
Fryczynski,
Dorman,
Everitt,
Gaido,
Ross,
Heck Hd,
Sonneveld,
Jansen,
Riteco,
Brouwer,
van der Burg,
Golub,
Gray,
Ostby,
Cooper,
Kelce,
Palanza,
Morellini,
Parmigiani,
vom Saal,
Craig Jordan,
Fort,
Thomas,
Rogers,
Noll,
Spaulding,
Guiney,
Weeks,
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- Effect of methoxychlor on reproductive systems of the rat. Bal, H.S. Proc. Soc. Exp. Biol. Med. (1984)
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- Evaluation of the developmental and reproductive toxicity of methoxychlor using an anuran (Xenopus tropicalis) chronic exposure model. Fort, D.J., Thomas, J.H., Rogers, R.L., Noll, A., Spaulding, C.D., Guiney, P.D., Weeks, J.A. Toxicol. Sci. (2004)
- The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behavior without affecting pituitary size or LH and prolactin secretion in male rats. Gray, L.E., Ostby, J., Cooper, R.L., Kelce, W.R. Toxicology and industrial health. (1999)
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- Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Gaido, K.W., Maness, S.C., McDonnell, D.P., Dehal, S.S., Kupfer, D., Safe, S. Mol. Pharmacol. (2000)
- Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. Miller, K.P., Gupta, R.K., Flaws, J.A. Toxicol. Sci. (2006)
- Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Maness, S.C., McDonnell, D.P., Gaido, K.W. Toxicol. Appl. Pharmacol. (1998)
- Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice. Welshons, W.V., Nagel, S.C., Thayer, K.A., Judy, B.M., Vom Saal, F.S. Toxicology and industrial health. (1999)
- The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor. Al-Jamal, J.H., Dubin, N.H. Am. J. Obstet. Gynecol. (2000)
- Methoxychlor disrupts uterine Hoxa10 gene expression. Fei, X., Chung, H., Taylor, H.S. Endocrinology (2005)
- Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Stresser, D.M., Kupfer, D. Biochemistry (1997)
- Activated estrogens and antiestrogens: a 30-year journey with David Kupfer. Craig Jordan, V. Drug Metab. Rev. (2006)
- Disruption of rat estrous cyclicity by the environmental estrogen 4-tert-octylphenol. Blake, C.A., Ashiru, O.A. Proc. Soc. Exp. Biol. Med. (1997)
- Studies on the formation of methoxychlor-protein adduct in rat and human liver microsomes. Is demethylation of methoxychlor essential for cytochrome P450 catalyzed covalent binding? Bulger, W.H., Kupfer, D. Biochem. Pharmacol. (1990)
- Metabolism of methoxychlor by hepatic P-450 monooxygenases in rat and human. 1. Characterization of a novel catechol metabolite. Kupfer, D., Bulger, W.H., Theoharides, A.D. Chem. Res. Toxicol. (1990)
- Effects of endocrine-disrupting contaminants on amphibian oogenesis: methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocytes in vitro. Pickford, D.B., Morris, I.D. Environ. Health Perspect. (1999)
- Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants. Bulger, W.H., Feil, V.J., Kupfer, D. Mol. Pharmacol. (1985)
- Biosynthetic incorporation of fluorescent carbazolylundecanoic acid into membrane phospholipids of LM cells and determination of quenching constants and partition coefficients of hydrophobic quenchers. Omann, G.M., Glaser, M. Biochemistry (1984)
- Intramolecular deuterium isotope effect and enantiotopic differentiation in oxidative demethylation of chiral [monomethyl-d3]methoxychlor in rat liver microsomes. Ichinose, R., Kurihara, N. Biochem. Pharmacol. (1987)
- Examination of purported probes of human CYP2B6. Ekins, S., VandenBranden, M., Ring, B.J., Wrighton, S.A. Pharmacogenetics (1997)
- Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation. Stresser, D.M., Kupfer, D. Drug Metab. Dispos. (1998)
- Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases. Hazai, E., Gagne, P.V., Kupfer, D. Drug Metab. Dispos. (2004)
- Enhanced biodegradation of methoxychlor in soil under sequential environmental conditions. Fogel, S., Lancione, R.L., Sewall, A.E. Appl. Environ. Microbiol. (1982)
- Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Sonneveld, E., Jansen, H.J., Riteco, J.A., Brouwer, A., van der Burg, B. Toxicol. Sci. (2005)
- Cognitive testing (delayed non-match to sample) during oral treatment of female adolescent monkeys with the estrogenic pesticide methoxychlor. Golub, M.S. Neurotoxicology and teratology. (2002)
- The pesticide methoxychlor disrupts the fusion of myoblasts into myotubes in skeletal muscle cell culture. Grow, W.A., Eroschenko, V.P. Toxicol. Appl. Pharmacol. (2002)