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Gene Review

Uox  -  urate oxidase

Mus musculus

Synonyms: AI663847, Urate oxidase, Uricase
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Disease relevance of Uox


High impact information on Uox


Chemical compound and disease context of Uox


Biological context of Uox


Anatomical context of Uox


Associations of Uox with chemical compounds

  • At day 300 the clofibrate treatment increased all activities although UOX was not significantly increased [15].
  • Urate oxidase, or uricase (EC, is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals [16].
  • Acyl-CoA oxidase, catalase and uricase activities were increased by 712%, 506% and 41% respectively by treatment with fenofibrate [17].
  • (6) The linear poly(ethylene glycol) conjugate was, among the various uricase forms, the species with the lowest distribution levels in all the examined organs [18].
  • The activity of catalase in the mitochondrial fraction from female mice was not affected by vitamin A deficiency, whereas the activity of peroxisomal urate oxidase was increased 2.9-fold [19].

Other interactions of Uox

  • In control mice, UOX activity was not affected by aging whereas CAT and AOX activities were significantly decreased [15].
  • In contrast, protein levels of two PPARalpha-unresponsive peroxisomal enzymes, catalase and urate oxidase, were not affected by the loss of STAT5b [20].
  • In the liver of mice fed this diet for 3 wk, hepatic catalase activity was increased to 140% while no induction of palmitoyl-CoA oxidase (EC, urate oxidase (EC, and L-alpha-hydroxyisovalerate oxidase (EC 1.1.3.a) was observed [21].
  • Induction of tolerance in mice by uricase and monomethoxypolyethylene glycol-modified uricase [22].

Analytical, diagnostic and therapeutic context of Uox


  1. Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Wu, X., Wakamiya, M., Vaishnav, S., Geske, R., Montgomery, C., Jones, P., Bradley, A., Caskey, C.T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Transformation of epithelial cells stably transfected with H2O2-generating peroxisomal urate oxidase. Chu, R., Lin, Y., Reddy, K.C., Pan, J., Rao, M.S., Reddy, J.K., Yeldandi, A.V. Cancer Res. (1996) [Pubmed]
  3. Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. Kelly, S.J., Delnomdedieu, M., Oliverio, M.I., Williams, L.D., Saifer, M.G., Sherman, M.R., Coffman, T.M., Johnson, G.A., Hershfield, M.S. J. Am. Soc. Nephrol. (2001) [Pubmed]
  4. Morphologic phenotyping with MR microscopy: the visible mouse. Johnson, G.A., Cofer, G.P., Gewalt, S.L., Hedlund, L.W. Radiology. (2002) [Pubmed]
  5. Tiadenol-mediated induction of peroxisomal enzymes in cultured C3H/10T1/2CL8 cells and in chemically transformed C3H/10T1/2 MCA16 cells. Berge, R.K., Lillehaug, J.R. Int. J. Cancer (1985) [Pubmed]
  6. Uric acid metabolism in homozygous and heterozygous muscular dystrophic mice. Dju, M.Y., Yü, T.F. Am. J. Physiol. (1978) [Pubmed]
  7. The mouse urate oxidase gene, Uox, maps to distal chromosome 3. Cook, S., Johnson, K., Davisson, M. Mamm. Genome (1997) [Pubmed]
  8. Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cook, S.A., Akeson, E.C., Calvano, C., Johnson, K.R., Mandell, J., Hawes, N.L., Bronson, R.T., Roderick, T.H., Davisson, M.T. Cytogenet. Cell Genet. (2001) [Pubmed]
  9. Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol. Fujita, T., Yasuda, Y., Takakura, Y., Hashida, M., Sezaki, H. J. Pharmacobio-dyn. (1991) [Pubmed]
  10. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Ramazzina, I., Folli, C., Secchi, A., Berni, R., Percudani, R. Nature chemical biology. (2006) [Pubmed]
  11. Mouse Transthyretin-related Protein Is a Hydrolase which Degrades 5-Hydroxyisourate, the End Product of the Uricase Reaction. Lee, Y., Park, B.C., Lee, d.o. .H., Bae, K.H., Cho, S., Lee, C.H., Lee, J.S., Myung, P.K., Park, S.G. Mol. Cells (2006) [Pubmed]
  12. Distribution and nature of epoxide hydrolase activity in subcellular organelles of mouse liver. Kaur, S., Gill, S.S. Biochem. Pharmacol. (1986) [Pubmed]
  13. Solubilization of particle-linked urate oxidase by different agents. Otta, M.E., Bertini, F. Acta physiologica latino americana. (1975) [Pubmed]
  14. Uptake of uric acid, xanthine and hypoxanthine by brush-border membrane vesicles from mouse small intestine. Shaw, M.I., Parsons, D.S. Biochim. Biophys. Acta (1984) [Pubmed]
  15. Liver peroxisomal fatty acid oxidizing system during aging in control and clofibrate-treated mice. Périchon, R., Bourre, J.M. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  16. Urate oxidase: primary structure and evolutionary implications. Wu, X.W., Lee, C.C., Muzny, D.M., Caskey, C.T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Hydrogen peroxide metabolism during peroxisome proliferation by fenofibrate. Arnaiz, S.L., Travacio, M., Llesuy, S., Boveris, A. Biochim. Biophys. Acta (1995) [Pubmed]
  18. Biopharmaceutical properties of uricase conjugated to neutral and amphiphilic polymers. Caliceti, P., Schiavon, O., Veronese, F.M. Bioconjug. Chem. (1999) [Pubmed]
  19. Effects of vitamin A deficiency on selected xenobiotic-metabolizing enzymes and defenses against oxidative stress in mouse liver. Sohlenius-Sternbeck, A.K., Appelkvist, E.L., DePierre, J.W. Biochem. Pharmacol. (2000) [Pubmed]
  20. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Zhou, Y.C., Davey, H.W., McLachlan, M.J., Xie, T., Waxman, D.J. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  21. Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. De Craemer, D., Pauwels, M., Van den Branden, C. Lipids (1996) [Pubmed]
  22. Induction of tolerance in mice by uricase and monomethoxypolyethylene glycol-modified uricase. Savoca, K.V., Davis, F.F., Palczuk, N.C. Int. Arch. Allergy Appl. Immunol. (1984) [Pubmed]
  23. Allopurinol/uricase and ibuprofen enhance engraftment of cardiomyocyte-enriched human embryonic stem cells and improve cardiac function following myocardial injury. Kofidis, T., Lebl, D.R., Swijnenburg, R.J., Greeve, J.M., Klima, U., Gold, J., Xu, C., Robbins, R.C. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2006) [Pubmed]
  24. Urate-oxidase in liver of oxonic acid treated mice. Otta, M.E., Bertini, F. Acta physiologica latino americana. (1978) [Pubmed]
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