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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Carcinine     3-amino-N-[2-(3H-imidazol-4...

Synonyms: Lopac-C-2321, CHEMBL461024, SureCN2819350, BSPBio_000404, ANW-66135, ...
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Disease relevance of Carcinine


Psychiatry related information on Carcinine


High impact information on Carcinine


Biological context of Carcinine


Associations of Carcinine with other chemical compounds

  • We demonstrate that when they receive microinjections into the head, wild-type Sarcophaga bullata (in whose larger head such injections are routinely possible) rapidly (<5 sec) convert exogenous [3H]histamine into its beta-alanine conjugate, carcinine, a novel metabolite [4].

Gene context of Carcinine

  • Electroretinogram and head histamine assays indicated that CG12120 is required for hydrolysis of carcinine to histamine, which is required for histaminergic neurotransmission [3].
  • Since naturally occurring carcinine shows in vivo antioxidant property, the SOD-like activity of the copper(II)-carcinine system has also been investigated and the complex CuLH(-1) was found to be highly active [5].
  • The equilibrium ratio between [3H]carcinine and [3H]histamine after microinjecting wild-type Sarcophaga favors carcinine hydrolysis, increasing to only 0.5 after 30 min [4].

Analytical, diagnostic and therapeutic context of Carcinine

  • Carcinine, L-prolylhistamine show efficient deactivation of lipid hydroperoxides monitored by HPLC and protection of membrane phospholipids and water soluble proteins from the lipid peroxides-induced damages [6].


  1. Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat. Steinberg, C., Notterman, D.A. Crit. Care Med. (1996) [Pubmed]
  2. Pharmacological effects of carcinine on histaminergic neurons in the brain. Chen, Z., Sakurai, E., Hu, W., Jin, C., Kiso, Y., Kato, M., Watanabe, T., Wei, E., Yanai, K. Br. J. Pharmacol. (2004) [Pubmed]
  3. Drosophila tan encodes a novel hydrolase required in pigmentation and vision. True, J.R., Yeh, S.D., Hovemann, B.T., Kemme, T., Meinertzhagen, I.A., Edwards, T.N., Liou, S.R., Han, Q., Li, J. PLoS Genet. (2005) [Pubmed]
  4. tan and ebony genes regulate a novel pathway for transmitter metabolism at fly photoreceptor terminals. Borycz, J., Borycz, J.A., Loubani, M., Meinertzhagen, I.A. J. Neurosci. (2002) [Pubmed]
  5. Reinvestigation of the copper(II)-carcinine equilibrium system: "two-dimensional" EPR simulation and NMR relaxation studies for determining the formation constants and coordination modes. Arkosi, Z., Paksi, Z., Korecz, L., Gajda, T., Henry, B., Rockenbauer, A. J. Inorg. Biochem. (2004) [Pubmed]
  6. Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products. Babizhayev, M.A. Life Sci. (2006) [Pubmed]
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