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Gene Review

Hdc  -  histidine decarboxylase

Mus musculus

Synonyms: AW108189, HDC, Hdc-a, Hdc-c, Hdc-e, ...
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Disease relevance of Hdc


Psychiatry related information on Hdc


High impact information on Hdc


Chemical compound and disease context of Hdc


Biological context of Hdc


Anatomical context of Hdc


Associations of Hdc with chemical compounds


Regulatory relationships of Hdc


Other interactions of Hdc

  • These results indicate that leptin increases histamine turnover by affecting the posttranscriptional process of HDC formation or histamine release per se [19].
  • Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient mice [2].
  • Cotransfection assays using HDC-luciferase reporter and p45 and/or mafK expression constructs showed that NF-E2 affects the transactivation of HDC gene [29].
  • By contrast, the mPer1 and mPer2 mRNA rhythms in the other brain areas such as the cortex and striatum were significantly disrupted in the HDC-/- mice [30].
  • BA exposure also caused significant inhibition of hepatic AHH, EROD and glutathione-S-transferase activities, with concomitant increases in the activities of histidase (52%) and HDC (58%) [31].

Analytical, diagnostic and therapeutic context of Hdc


  1. Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Yokoyama, M., Yokoyama, A., Mori, S., Takahashi, H.K., Yoshino, T., Watanabe, T., Watanabe, T., Ohtsu, H., Nishibori, M. Gastroenterology (2004) [Pubmed]
  2. Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient mice. Hirai, T., Okuma, C., Harada, C., Mio, M., Ohtsu, H., Watanabe, T., Kamei, C. Epilepsia (2004) [Pubmed]
  3. Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. Joseph, D.R., Sullivan, P.M., Wang, Y.M., Kozak, C., Fenstermacher, D.A., Behrendsen, M.E., Zahnow, C.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers. Pós, Z., Sáfrány, G., Müller, K., Tóth, S., Falus, A., Hegyesi, H. Cancer Res. (2005) [Pubmed]
  5. Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Bartholeyns, J., Bouclier, M. Cancer Res. (1984) [Pubmed]
  6. Increased methamphetamine-induced locomotor activity and behavioral sensitization in histamine-deficient mice. Kubota, Y., Ito, C., Sakurai, E., Sakurai, E., Watanabe, T., Ohtsu, H. J. Neurochem. (2002) [Pubmed]
  7. Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. Yoshida, A., Mobarakeh, J.I., Sakurai, E., Sakurada, S., Orito, T., Kuramasu, A., Kato, M., Yanai, K. Eur. J. Pharmacol. (2005) [Pubmed]
  8. The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward. Brabant, C., Quertemont, E., Anaclet, C., Lin, J.S., Ohtsu, H., Tirelli, E. Psychopharmacology (Berl.) (2007) [Pubmed]
  9. Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge. Yoshimoto, R., Miyamoto, Y., Takahashi, K., Kotani, H., Kanatani, A., Tokita, S. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  10. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. Xu, X., Zhang, D., Zhang, H., Wolters, P.J., Killeen, N.P., Sullivan, B.M., Locksley, R.M., Lowell, C.A., Caughey, G.H. J. Exp. Med. (2006) [Pubmed]
  11. Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels. Schneider, E., Machavoine, F., Pléau, J.M., Bertron, A.F., Thurmond, R.L., Ohtsu, H., Watanabe, T., Schinkel, A.H., Dy, M. J. Exp. Med. (2005) [Pubmed]
  12. Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. Ghosh, A.K., Hirasawa, N., Ohtsu, H., Watanabe, T., Ohuchi, K. J. Exp. Med. (2002) [Pubmed]
  13. Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells. Tanaka, S., Takasu, Y., Mikura, S., Satoh, N., Ichikawa, A. J. Exp. Med. (2002) [Pubmed]
  14. cDNA-derived amino acid sequence of L-histidine decarboxylase from mouse mastocytoma P-815 cells. Yamamoto, J., Yatsunami, K., Ohmori, E., Sugimoto, Y., Fukui, T., Katayama, T., Ichikawa, A. FEBS Lett. (1990) [Pubmed]
  15. Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity. Garaczi, E., Széll, M., Jánossy, T., Koreck, A., Pivarcsi, A., Buzás, E., Pos, Z., Falus, A., Dobozy, A., Kemény, L. Int. Immunol. (2004) [Pubmed]
  16. Enhanced expression of the mouse L-histidine decarboxylase gene with a combination of dexamethasone and 12-O-tetradecanoylphorbol-13-acetate. Ohgoh, M., Yamamoto, J., Kawata, M., Yamamura, I., Fukui, T., Ichikawa, A. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  17. Histidine decarboxylase phenotypes of inbred mouse strains: a regulatory locus (Hdc) determines kidney enzyme concentration. Martin, S.A., Taylor, B.A., Watanabe, T., Bulfield, G. Biochem. Genet. (1984) [Pubmed]
  18. Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice. Fitzsimons, C.P., Lazar-Molnar, E., Tomoskozi, Z., Buzás, E., Rivera, E.S., Falus, A. FEBS Lett. (2001) [Pubmed]
  19. Hypothalamic neuronal histamine as a target of leptin in feeding behavior. Yoshimatsu, H., Itateyama, E., Kondou, S., Tajima, D., Himeno, K., Hidaka, S., Kurokawa, M., Sakata, T. Diabetes (1999) [Pubmed]
  20. Induction of histidine and ornithine decarboxylase activities in mouse tissues by recombinant interleukin-1 and tumor necrosis factor. Endo, Y. Biochem. Pharmacol. (1989) [Pubmed]
  21. Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects leydig cell function. Mondillo, C., Falus, A., Pignataro, O., Pap, E. J. Androl. (2007) [Pubmed]
  22. Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice. Acevedo, S.F., Ohtsu, H., Benice, T.S., Rizk-Jackson, A., Raber, J. Brain Res. (2006) [Pubmed]
  23. Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Fülöp, A.K., Földes, A., Buzás, E., Hegyi, K., Miklós, I.H., Romics, L., Kleiber, M., Nagy, A., Falus, A., Kovács, K.J. Endocrinology (2003) [Pubmed]
  24. GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in vivo. Endo, Y., Kikuchi, T., Takeda, Y., Nitta, Y., Rikiishi, H., Kumagai, K. Immunol. Lett. (1992) [Pubmed]
  25. IL-3-induced coexpression of histidine decarboxylase, IL-4 and IL-6 mRNA by murine basophil precursors. Schneider, E., Lemoine, F.M., Breton-Gorius, J., Machavoine, F., Arnould, A., Cramer, E.M., Guichard, J., Michel, D. Exp. Hematol. (1999) [Pubmed]
  26. Histidine decarboxylase gene in the mouse uterus is regulated by progesterone and correlates with uterine differentiation for blastocyst implantation. Paria, B.C., Das, N., Das, S.K., Zhao, X., Dileepan, K.N., Dey, S.K. Endocrinology (1998) [Pubmed]
  27. Crucial role of histamine for regulation of gastric acid secretion ascertained by histidine decarboxylase-knockout mice. Furutani, K., Aihara, T., Nakamura, E., Tanaka, S., Ichikawa, A., Ohtsu, H., Okabe, S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  28. Effect of lipopolysaccharides on histamine synthesis by hematopoietic cells. Piquet-Pellorce, C., Dy, M. Cell. Immunol. (1991) [Pubmed]
  29. Histidine decarboxylase expression in mouse mast cell line P815 is induced by mouse peritoneal cavity incubation. Ohtsu, H., Kuramasu, A., Suzuki, S., Igarashi, K., Ohuchi, Y., Sato, M., Tanaka, S., Nakagawa, S., Shirato, K., Yamamoto, M., Ichikawa, A., Watanabe, T. J. Biol. Chem. (1996) [Pubmed]
  30. Circadian rhythms in behavior and clock gene expressions in the brain of mice lacking histidine decarboxylase. Abe, H., Honma, S., Ohtsu, H., Honma, K. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  31. Modulation by ascorbic acid of the cutaneous and hepatic biochemical effects induced by topically applied benzanthrone in mice. Dwivedi, N., Das, M., Joshi, A., Singh, G.B., Khanna, S.K. Food Chem. Toxicol. (1993) [Pubmed]
  32. Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Fitzpatrick, L.A., Buzas, E., Gagne, T.J., Nagy, A., Horvath, C., Ferencz, V., Mester, A., Kari, B., Ruan, M., Falus, A., Barsony, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  33. Induction of histidine decarboxylase in skeletal muscle in mice by electrical stimulation, prolonged walking and interleukin-1. Endo, Y., Tabata, T., Kuroda, H., Tadano, T., Matsushima, K., Watanabe, M. J. Physiol. (Lond.) (1998) [Pubmed]
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