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Chemical Compound Review

2,4,5-T     2-(2,4,5- trichlorophenoxy)ethanoic acid

Synonyms: Brushtox, Crossbow, Trioxone, Arbokan, Phortox, ...
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Disease relevance of 2,4,5-trichlorophenoxyacetic acid


Psychiatry related information on 2,4,5-trichlorophenoxyacetic acid


High impact information on 2,4,5-trichlorophenoxyacetic acid


Chemical compound and disease context of 2,4,5-trichlorophenoxyacetic acid


Biological context of 2,4,5-trichlorophenoxyacetic acid


Anatomical context of 2,4,5-trichlorophenoxyacetic acid


Associations of 2,4,5-trichlorophenoxyacetic acid with other chemical compounds


Gene context of 2,4,5-trichlorophenoxyacetic acid


Analytical, diagnostic and therapeutic context of 2,4,5-trichlorophenoxyacetic acid

  • Spectrophotometry and gas chromatography reveal various intermediates during growth of the culture with 2,4,5-T [28].
  • The technique of plasmid-assisted molecular breeding has led to the development of bacterial strains capable of totally degrading 2,4,5-T by using it as their sole source of carbon at high concentrations (greater than 1 mg/ml) [28].
  • A clinical epidemiologic study was conducted to determine the long-term health effects of workplace exposure to the process of manufacturing the herbicide (2,4,5-trichlorophenoxy)acetic acid including contaminants such as 2,3,7,8-tetrachlorodibenzo-rho-dioxin [29].
  • A randomized biomechanical study was carried out by installing 13-mm-long meniscus arrows into fresh porcine menisci with the Crossbow and with the standard manual inserter trocar system [30].
  • Reversed-phase high-performance liquid chromatography (HPLC) analysis of bile indicated that more than 85% of compound excreted in bile was unchanged 2,4,5-T [31].


  1. Aerial spraying of 2,4,5-T and human birth malformations: an epidemiological investigation. Hanify, J.A., Metcalf, P., Nobbs, C.L., Worsley, K.J. Science (1981) [Pubmed]
  2. 2,4,5-T, trichlorophenol, and soft tissue sarcoma. Honchar, P.A., Halperin, W.E. Lancet (1981) [Pubmed]
  3. Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluorooctanoic acid and nafenopin. Abdellatif, A.G., Préat, V., Vamecq, J., Nilsson, R., Roberfroid, M. Carcinogenesis (1990) [Pubmed]
  4. Cloning and characterization of a chromosomal DNA region required for growth on 2,4,5-T by Pseudomonas cepacia AC1100. Haugland, R.A., Sangodkar, U.M., Sferra, P.R., Chakrabarty, A.M. Gene (1991) [Pubmed]
  5. Substrate diversity and expression of the 2,4,5-trichlorophenoxyacetic acid oxygenase from Burkholderia cepacia AC1100. Danganan, C.E., Shankar, S., Ye, R.W., Chakrabarty, A.M. Appl. Environ. Microbiol. (1995) [Pubmed]
  6. Conditioned taste aversion to saccharin induced by 2, 4, 5-trichlorophenoxyacetic acid in albino rats. Sjödén, P.O., Archer, T. Physiol. Behav. (1977) [Pubmed]
  7. Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site. Umbreit, T.H., Hesse, E.J., Gallo, M.A. Science (1986) [Pubmed]
  8. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses. Smith, A.H., Patterson, D.G., Warner, M.L., MacKenzie, R., Needham, L.L. J. Natl. Cancer Inst. (1992) [Pubmed]
  9. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. Smith, A.H., Pearce, N.E., Fisher, D.O., Giles, H.J., Teague, C.A., Howard, J.K. J. Natl. Cancer Inst. (1984) [Pubmed]
  10. Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells. Melnikov, A., Zaborina, O., Dhiman, N., Prabhakar, B.S., Chakrabarty, A.M., Hendrickson, W. Mol. Microbiol. (2000) [Pubmed]
  11. Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver. Wielandt, A.M., Vollrath, V., Manzano, M., Miranda, S., Accatino, L., Chianale, J. Biochem. J. (1999) [Pubmed]
  12. Degradation of the chlorinated phenoxyacetate herbicides 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid by pure and mixed bacterial cultures. Haugland, R.A., Schlemm, D.J., Lyons, R.P., Sferra, P.R., Chakrabarty, A.M. Appl. Environ. Microbiol. (1990) [Pubmed]
  13. Purification of hydroxyquinol 1,2-dioxygenase and maleylacetate reductase: the lower pathway of 2,4,5-trichlorophenoxyacetic acid metabolism by Burkholderia cepacia AC1100. Daubaras, D.L., Saido, K., Chakrabarty, A.M. Appl. Environ. Microbiol. (1996) [Pubmed]
  14. Metabolism of Halophenols by 2,4,5-trichlorophenoxyacetic acid-degrading Pseudomonas cepacia. Karns, J.S., Kilbane, J.J., Duttagupta, S., Chakrabarty, A.M. Appl. Environ. Microbiol. (1983) [Pubmed]
  15. Novel 2,4-dichlorophenoxyacetic acid degradation genes from oligotrophic Bradyrhizobium sp. strain HW13 isolated from a pristine environment. Kitagawa, W., Takami, S., Miyauchi, K., Masai, E., Kamagata, Y., Tiedje, J.M., Fukuda, M. J. Bacteriol. (2002) [Pubmed]
  16. Sequence analysis of a gene cluster involved in metabolism of 2,4,5-trichlorophenoxyacetic acid by Burkholderia cepacia AC1100. Daubaras, D.L., Hershberger, C.D., Kitano, K., Chakrabarty, A.M. Appl. Environ. Microbiol. (1995) [Pubmed]
  17. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver. Miranda, S., Vollrath, V., Wielandt, A.M., Loyola, G., Bronfman, M., Chianale, J. J. Hepatol. (1997) [Pubmed]
  18. Induction of cytosolic and microsomal epoxide hydrolases and proliferation of peroxisomes and mitochondria in mouse liver after dietary exposure to p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. Lundgren, B., Meijer, J., DePierre, J.W. Biochem. Pharmacol. (1987) [Pubmed]
  19. Transport of 2,4,5-trichlorophenoxyacetic acid across the blood-cerebrospinal fluid barrier of the rabbit. Kim, C.S., Pritchard, J.B. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  20. Trace analysis of 2,4,5-trichlorophenoxyacetic acid, its glycineamide, and their alkaline hydrolyzable conjugates in mouse blood, urine, and feces. Nony, C.R., Bowman, M.C., Holder, C.L., Young, J.F., Oller, W.L. Journal of pharmaceutical sciences. (1976) [Pubmed]
  21. Overview of potential mutagenic problems posed by some pesticides and their trace impurities. Fishbein, L. Environ. Health Perspect. (1978) [Pubmed]
  22. Use of the Drosophila wing spot test in the genotoxicity testing of different herbicides. Kaya, B., Creus, A., Yanikoğlu, A., Cabré, O., Marcos, R. Environ. Mol. Mutagen. (2000) [Pubmed]
  23. Correlation between the activation of Neu tyrosine kinase and promotion of foci formation induced by selected organochlorine compounds in the MCF-7 model system. Hatakeyama, M., Matsumura, F. J. Biochem. Mol. Toxicol. (1999) [Pubmed]
  24. Effect of peroxisome proliferators on glutathione-dependent sulphobromophthalein excretion. James, S.I., Ahokas, J.T. Xenobiotica (1992) [Pubmed]
  25. Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid. Lundgren, B., Meijer, J., Birberg, W., Pilotti, A., Depierre, J.W. Chem. Biol. Interact. (1988) [Pubmed]
  26. Retarded development of fetal renal alkaline phosphatase in mice given 2,4,5-trichlorophenoxyacetic acid. Highman, B., Gaines, T.B., Schumacher, H.J. Journal of toxicology and environmental health. (1977) [Pubmed]
  27. Effect of exposure of Pieris brassicae larvae to 2,4,5-trichlorophenoxyacetic acid on the natural antibacterial activity of serum. Jones, R.D., Rowley, A.F., Ratcliffe, N.A. J. Invertebr. Pathol. (1989) [Pubmed]
  28. Plasmid-assisted molecular breeding: new technique for enhanced biodegradation of persistent toxic chemicals. Kellogg, S.T., Chatterjee, D.K., Chakrabarty, A.M. Science (1981) [Pubmed]
  29. Human health effects of 2,4,5-T and its toxic contaminants. Suskind, R.R., Hertzberg, V.S. JAMA (1984) [Pubmed]
  30. A novel inserter instrument (Crossbow) for installation of self-reinforced bioabsorbable arrows into meniscus tissue. Törmälä, P., Karhi, O., Koho, P., Tamminmäki, M. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. (2000) [Pubmed]
  31. Biliary excretion of 2,4,5-trichlorophenoxyacetic acid in the rat. Eaton, D.L. Toxicol. Lett. (1982) [Pubmed]
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