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Chemical Compound Review

Phenoxyacetate     2-phenoxyethanoic acid

Synonyms: SureCN8127, CHEMBL173521, NSC-9810, ACMC-1BC4K, CCRIS 7275, ...
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Disease relevance of Glycollic acid phenyl ether


High impact information on Glycollic acid phenyl ether


Chemical compound and disease context of Glycollic acid phenyl ether


Biological context of Glycollic acid phenyl ether


Anatomical context of Glycollic acid phenyl ether


Associations of Glycollic acid phenyl ether with other chemical compounds


Gene context of Glycollic acid phenyl ether

  • In order to improve the biological characteristics of DA-3934 (5), a novel gastrin/cholecystokinin (CCK)-B receptor antagonist, phenoxyacetic acid derivatives replacing the N-methyl-N-phenylcarbamoylmethyl moiety of 5 with various alkyl chains have been synthesized and their biological activity evaluated [24].
  • Establishment of phenoxyacetic-acid-degrading soil populations by conjugal transfer of tfdA would depend on the presence of phenol-degrading recipients employing an ortho cleavage of catechol [25].
  • Conversely, inhibition of Candida albicans Sap2 was higher for the S,S,S epimers, and Poa or its hydrophilic derivatives were preferred over dmPoa [26].
  • The mode of action of BM 13.177 (4-[2-(benzenesulfonamido)-ethyl] phenoxyacetic acid), a new anti-aggregating and anti-thrombotic agent, was studied in human washed platelets and citrated PRP [27].
  • Tienilic acid, a phenoxyacetic acid diuretic, reduces the amount of total sulphobromophthalein (BSP) excretion in the isolated perfused rat liver (IPRL) [28].

Analytical, diagnostic and therapeutic context of Glycollic acid phenyl ether


  1. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington. Woods, J.S., Polissar, L., Severson, R.K., Heuser, L.S., Kulander, B.G. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Incidence rates of leukemias, lymphomas and myelomas in Italy: geographic distribution and NHL histotypes. Masala, G., Di Lollo, S., Picoco, C., Crosignani, P., Demicheli, V., Fontana, A., Funtó, I., Miligi, L., Nanni, O., Papucci, A., Ramazzotti, V., Rodella, S., Stagnaro, E., Tumino, R., Viganó, C., Vindigni, C., Seniori Costantini, A., Vineis, P. Int. J. Cancer (1996) [Pubmed]
  3. The role of occupational exposure and immunodeficiency in B-cell malignancies. Working Group on the Epidemiology of Hematolymphopoietic Malignancies in Italy. Vineis, P., D'Amore, F. Epidemiology (Cambridge, Mass.) (1992) [Pubmed]
  4. Isolation and characterization of the pesticide-degrading plasmid pJP1 from Alcaligenes paradoxus. Fisher, P.R., Appleton, J., Pemberton, J.M. J. Bacteriol. (1978) [Pubmed]
  5. Biodegradation of phenoxyacetic acid in soil by Pseudomonas putida PP0301(pR0103), a constitutive degrader of 2,4-dichlorophenoxyacetate. Short, K.A., King, R.J., Seidler, R.J., Olsen, R.H. Mol. Ecol. (1992) [Pubmed]
  6. Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver. Miranda, S., Vollrath, V., Wielandt, A.M., Loyola, G., Bronfman, M., Chianale, J. J. Hepatol. (1997) [Pubmed]
  7. Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. Regan, J., McGarry, D., Bruno, J., Green, D., Newman, J., Hsu, C.Y., Kline, J., Barton, J., Travis, J., Choi, Y.M., Volz, F., Pauls, H., Harrison, R., Zilberstein, A., Ben-Sasson, S.A., Chang, M. J. Med. Chem. (1997) [Pubmed]
  8. Nonsulfhydryl-reactive phenoxyacetic acids increase aqueous humor outflow facility. Epstein, D.L., Roberts, B.C., Skinner, L.L. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  9. Contraluminal organic anion and cation transport in the proximal renal tubule: V. Interaction with sulfamoyl- and phenoxy diuretics, and with beta-lactam antibiotics. Ullrich, K.J., Rumrich, G., Klöss, S. Kidney Int. (1989) [Pubmed]
  10. Agonist potency at the cloned human beta-3 adrenoceptor depends on receptor expression level and nature of assay. Wilson, S., Chambers, J.K., Park, J.E., Ladurner, A., Cronk, D.W., Chapman, C.G., Kallender, H., Browne, M.J., Murphy, G.J., Young, P.W. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  11. Properties of six pesticide degradation plasmids isolated from Alcaligenes paradoxus and Alcaligenes eutrophus. Don, R.H., Pemberton, J.M. J. Bacteriol. (1981) [Pubmed]
  12. Modelling of the protonophoric uncoupling by phenoxyacetic acid of the plasma membrane potential of Penicillium chrysogenum. Henriksen, C.M., Nielsen, J., Villadsen, J. Biotechnol. Bioeng. (1998) [Pubmed]
  13. A colorimetric assay for penicillin-V amidase. Kerr, D.E. Anal. Biochem. (1993) [Pubmed]
  14. Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. Teixeira, M.C., Sá-Correia, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. The fate of a thiazolidinedione antidiabetic agent in rat and dog. Bolton, G.C., Keogh, J.P., East, P.D., Hollis, F.J., Shore, A.D. Xenobiotica (1996) [Pubmed]
  16. The acid metabolite of ZD7114 is a partial agonist of lipolysis mediated by the rat beta 3-adrenoceptor. Mayers, R.M., Quayle, S.P., Thompson, A.J., Grant, T.L., Holloway, B.R. Eur. J. Pharmacol. (1996) [Pubmed]
  17. Effects of phenoxyacetic acids on the induction of chromosome aberrations in vitro and in vivo. Mustonen, R., Kangas, J., Vuojolahti, P., Linnainmaa, K. Mutagenesis (1986) [Pubmed]
  18. Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids. Boosalis, M.S., Ikuta, T., Pace, B.S., da Fonseca, S., White, G.L., Faller, D.V., Perrine, S.P. Blood Cells Mol. Dis. (1997) [Pubmed]
  19. Sensitivity of cAMP-stimulated salt secretion in shark rectal gland to "loop" diuretics. Palfrey, H.C., Silva, P., Epstein, F.H. Am. J. Physiol. (1984) [Pubmed]
  20. Assay for detection and enumeration of genetically engineered microorganisms which is based on the activity of a deregulated 2,4-dichlorophenoxyacetate monooxygenase. King, R.J., Short, K.A., Seidler, R.J. Appl. Environ. Microbiol. (1991) [Pubmed]
  21. Metal ion-dependent molecular inclusion chemistry: inclusion of aromatic anions by coordinated 1,4,7,10-tetrakis((S)-2-hydroxy-3-phenoxypropyl)-1,4,7,10-tetraazacyclododecane. Smith, C.B., Stephens, A.K., Wallwork, K.S., Lincoln, S.F., Taylor, M.R., Wainwright, K.P. Inorganic chemistry. (2002) [Pubmed]
  22. Degradation of 2,4-dichlorophenoxyacetic acid by ionizing radiation: influence of oxygen concentration. Zona, R., Solar, S., Gehringer, P. Water Res. (2002) [Pubmed]
  23. Utilization of side-chain precursors for penicillin biosynthesis in a high-producing strain of Penicillium chrysogenum. Eriksen, S.H., Jensen, B., Schneider, I., Kaasgaard, S., Olsen, J. Appl. Microbiol. Biotechnol. (1994) [Pubmed]
  24. Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. III. Takeda, Y., Kawagoe, K., Yokomizo, A., Yokomizo, Y., Hosokami, T., Shimoto, Y., Tabuchi, Y., Ogihara, Y., Honda, Y., Kawarabayashi, K., Iseri, M., Yokohama, S. Chem. Pharm. Bull. (1999) [Pubmed]
  25. Utilization of phenoxyacetic acid, by strains using either the ortho or meta cleavage of catechol during phenol degradation, after conjugal transfer of tfdA, the gene encoding a 2,4-dichlorophenoxyacetic acid/2-oxoglutarate dioxygenase. Radnoti de Lipthay, J., Barkay, T., Vekova, J., Sørensen, S.J. Appl. Microbiol. Biotechnol. (1999) [Pubmed]
  26. Small hydroxyethylene-based peptidomimetics inhibiting both HIV-1 and C. albicans aspartic proteases. Tossi, A., Benedetti, F., Norbedo, S., Skrbec, D., Berti, F., Romeo, D. Bioorg. Med. Chem. (2003) [Pubmed]
  27. Investigation on a selective non-prostanoic thromboxane antagonist, BM 13.177, in human platelets. Patscheke, H., Stegmeier, K. Thromb. Res. (1984) [Pubmed]
  28. Effect of the glutathione S-transferase inhibitor, tienilic acid, on biliary excretion of sulphobromophthalein. Fehring, S.I., Ahokas, J.T. Chem. Biol. Interact. (1989) [Pubmed]
  29. Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation. Bührer, C., Bahr, S., Siebert, J., Wettstein, R., Geffers, C., Obladen, M. J. Hosp. Infect. (2002) [Pubmed]
  30. Radioiodinated phenoxyacetic acid derivatives as potential brain imaging agents. II. Structure-biodistribution relationship. Ohmomo, Y., Okuyama, S., Magata, Y., Ueno, Y., Tanaka, C., Yokoyama, A. Chem. Pharm. Bull. (1989) [Pubmed]
  31. Adaptative responses in yeast to the herbicide 2-methyl-4-chlorophenoxyacetic acid at the level of intracellular pH homeostasis. Guadalupe Cabral, M., Sá-Correia, I., Viegas, C.A. J. Appl. Microbiol. (2004) [Pubmed]
  32. Effect of molecular parameters on the binding of phenoxyacetic acid derivatives to albumins. Cserháti, T., Forgács, E., Deyl, Z., Miksík, I. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
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