Disease relevance of Tubeimoside I

• Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum [1].
• Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro [2].

High impact information on Tubeimoside I

• Role of mitochondria and mitochondrial cytochrome c in tubeimoside I-mediated apoptosis of human cervical carcinoma HeLa cell line [3].
• Two functional parameters evaluated by nitroblue tetrazolium (NBT) dye reduction and zymosan particle phagocytosis and a morphological change assessed by the Wright-Giemsa stain of human promyelocytic leukemia cells (HL-60 cells) were used to determine the extent of HL-60 cell differentiation induced by tubeimoside 1 [4].
• The purpose of the present study was to examine in vivo pharmacokinetics and bioavailability of tubeimoside I in rats by using a liquid chromatography coupled with mass spectrometry quantitative detection method (LC/MS) [5].
• The method was further applied to assess pharmacokinetics and oral bioavailability of tubeimoside I after intravenous and oral administration to rats [5].

Biological context of Tubeimoside I

• The oral bioavailability of tubeimoside I is only 0.23%, which indicates that tubeimoside I has poor absorption or undergoes acid-induced degradation [5].

Anatomical context of Tubeimoside I

• The results revealed that under the action of tubeimoside 1, HL-60 cells could be induced to differentiate to more mature cells with the functional characteristics of granulocytes [4].

Analytical, diagnostic and therapeutic context of Tubeimoside I

• Furthermore, a potent anti-tumorigenic effect of tubeimoside 1 was observed in 2-stage carcinogenesis of mouse skin after oral administration as well as topical application [6].
• Thus, tubeimoside 1 appears to be a promising agent for cancer chemoprevention [6].
• Tubeimoside I, a new cyclic bisdesmoside from Chinese cucurbitaceous folk medicine "tu bei mu", a tuber of Bolbostemma paniculatum [7].
• Quantitative determination of the anticancer agent tubeimoside I in rat plasma by liquid chromatography coupled with mass spectrometry [5].

References