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Chemical Compound Review:

Dolagial 2-[(3-chloro-2-methyl- phenyl)amino]pyridin...

Synonyms: Dorixina, Dolalgial, AC1MIVTI, Clonixil (TN), CHEBI:76201, ...

Pallapies, D. et al., Bidlingmaier, A. et al., Pineros, I. et al., Ortí, E. et al., Bustamante, D. et al., et al.

Pineros, Ballesteros, Lastres, Ortí, Coirini, Pico,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lysine clonixinate

Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study [1].
Lysine clonixinate in the treatment of primary dysmenorrhea [2].

High impact information on Lysine clonixinate

The intrathecal (i.t.) but not i.c.v. administration of aspirin, indomethacin, ketoprofen and lysine clonixinate resulted in dose-dependent depressions of the C-fiber reflex [3].
In vivo and in vitro effects of lysine clonixinate on nitric oxide synthase in LPS-treated and untreated rat lung preparations [4].
Increased (p < 0.05) labeling of mu receptors was observed in thalamic nuclei, gyrus dentate, and layers of the parietal cortex of rats treated for 10 days with lysine clonixinate [5].
Effects of lysine clonixinate on cyclooxygenase I and II in rat lung and stomach preparations [6].
Pharmacokinetics of lysine clonixinate in children in postoperative care [7].

Chemical compound and disease context of Lysine clonixinate

Lysine Clonixinate vs Naproxen Sodium for the Acute Treatment of Migraine: A Double-Blind, Randomized, Crossover Study [8].

Anatomical context of Lysine clonixinate

The release of prostanoids from rat brain, gastric mucosa, lungs and kidneys incubated ex vivo has been investigated for up to 5 h after oral administration of 10 mg/kg lysine clonixinate or 1 mg/kg ketorolac tromethamine [9].

Associations of Lysine clonixinate with other chemical compounds

In the ibuprofen and lysine clonixinate treatment groups the values of mean daily blood loss decreased during the wash-out phase with respect to the verum phase, whereas the mean daily blood loss during the wash-out phase after treatment with ASA even increased in comparison to the verum phase (mean daily blood loss: +2.07 ml/d versus baseline [10].

Gene context of Lysine clonixinate

In all organs investigated both drugs inhibited fatty acid cyclooxygenase (COX) in a dose-dependent manner, but ketorolac tromethamine was more potent and had a longer-lasting effect than lysine clonixinate [9].
Our results indicate that lysine clonixinate is a cyclooxygenase inhibitor of moderate potency [11].

Analytical, diagnostic and therapeutic context of Lysine clonixinate

A new reversed-phase high performance liquid chromatography method has been developed and validated for the quantitative determination of lysine clonixinate salt in water/oil microemulsions [12].

References

Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study. Krymchantowski, A.V., Barbosa, J.S., Cheim, C., Alves, L.A. Arquivos de neuro-psiquiatria. (2001) [Pubmed]
Lysine clonixinate in the treatment of primary dysmenorrhea. Di Girolamo, G., Zmijanovich, R., de los Santos, A.R., Martí, M.L., Terragno, A. Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología. (1996) [Pubmed]
Effects of intrathecal or intracerebroventricular administration of nonsteroidal anti-inflammatory drugs on a C-fiber reflex in rats. Bustamante, D., Paeile, C., Willer, J.C., Le Bars, D. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
In vivo and in vitro effects of lysine clonixinate on nitric oxide synthase in LPS-treated and untreated rat lung preparations. Franchi, A.M., Di Girolamo, G., Farina, M., de los Santos, A.R., Martí, M.L., Gimeno, M.A. Nitric Oxide (2001) [Pubmed]
Site-specific effects of the nonsteroidal anti-inflammatory drug lysine clonixinate on rat brain opioid receptors. Ortí, E., Coirini, H., Pico, J.C. Pharmacology (1999) [Pubmed]
Effects of lysine clonixinate on cyclooxygenase I and II in rat lung and stomach preparations. Franchi, A.M., Di Girolamo, G., de los Santos, A.R., Martí, M.L., Gimeno, M.A. Prostaglandins Leukot. Essent. Fatty Acids (1998) [Pubmed]
Pharmacokinetics of lysine clonixinate in children in postoperative care. González-Martin, G., Cattan, C., Zuñiga, S. International journal of clinical pharmacology and therapeutics. (1996) [Pubmed]
Lysine Clonixinate vs Naproxen Sodium for the Acute Treatment of Migraine: A Double-Blind, Randomized, Crossover Study. Krymchantowski, A.V., Peixoto, P., Higashi, R., Silva, A. MedGenMed [electronic resource] : Medscape general medicine. (2005) [Pubmed]
Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo. Pallapies, D., Salinger, A., Meyer zum Gottesberge, A., Atkins, D.J., Rohleder, G., Nagyiványi, P., Peskar, B.A. Life Sci. (1995) [Pubmed]
Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs. Bidlingmaier, A., Hammermaier, A., Nagyiványi, P., Pabst, G., Waitzinger, J. Arzneimittel-Forschung. (1995) [Pubmed]
Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man. Pallapies, D., Muhs, A., Bertram, L., Rohleder, G., Nagyiványi, P., Peskar, B.A. Eur. J. Clin. Pharmacol. (1996) [Pubmed]
Extraction and LC determination of lysine clonixinate salt in water/oil microemulsions. Pineros, I., Ballesteros, P., Lastres, J.L. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]

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